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Effects of Ginkgo biloba administered after spatial learning on water maze and radial arm maze performance in young adult rats.
Pharmacol Biochem Behav. 2006 May; 84(1):17-25.PB

Abstract

Ginkgo biloba is reported to improve learning and memory in animals. However, many studies do not directly test the effects of Ginkgo on memory because the drug is administered during the learning phase of the experiments. In this study, we examined the effect of 10 mg/kg, 20 mg/kg, or 40 mg/kg G. biloba extract on spatial memory by administering the drug in the interval between training and testing. Rats were tested for long-term reference memory retention in the radial arm maze and in the Morris water maze during daily probe trials in which the hidden platform was removed. G. biloba had no effect on reference memory in either the water maze or radial arm maze. To test short-term working spatial memory using the radial arm maze, animals were removed after receiving the reward from 4 of the 8 arms and were returned to complete the maze 2 h later. While Ginkgo had no effect on working memory, over time animals exposed to Ginkgo learned task better than control animals. Thus, Ginkgo appears to enhance neither short-term working memory nor long-term reference memory, but it may promote learning of spatial information.

Authors+Show Affiliations

Shif O
Department of Biology, Arcadia University, 450 South Easton Road, Glenside, PA 19038, USA.
Gillette K
No affiliation info available
Damkaoutis CM
No affiliation info available
Carrano C
No affiliation info available
Robbins SJ
No affiliation info available
Hoffman JR
No affiliation info available

MeSH

AnimalsBehavior, AnimalGinkgo bilobaMaleMaze LearningRatsRats, Sprague-Dawley

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16740301

Clinical Trial Links

Effect of Polyphenol-rich Cocoa Products on Cognitive Function

Citation

Shif, Olga, et al. "Effects of Ginkgo Biloba Administered After Spatial Learning On Water Maze and Radial Arm Maze Performance in Young Adult Rats." Pharmacology, Biochemistry, and Behavior, vol. 84, no. 1, 2006, pp. 17-25.
Shif O, Gillette K, Damkaoutis CM, et al. Effects of Ginkgo biloba administered after spatial learning on water maze and radial arm maze performance in young adult rats. Pharmacol Biochem Behav. 2006;84(1):17-25.
Shif, O., Gillette, K., Damkaoutis, C. M., Carrano, C., Robbins, S. J., & Hoffman, J. R. (2006). Effects of Ginkgo biloba administered after spatial learning on water maze and radial arm maze performance in young adult rats. Pharmacology, Biochemistry, and Behavior, 84(1), 17-25.
Shif O, et al. Effects of Ginkgo Biloba Administered After Spatial Learning On Water Maze and Radial Arm Maze Performance in Young Adult Rats. Pharmacol Biochem Behav. 2006;84(1):17-25. PubMed PMID: 16740301.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of Ginkgo biloba administered after spatial learning on water maze and radial arm maze performance in young adult rats. AU - Shif,Olga, AU - Gillette,Katie, AU - Damkaoutis,Christa M, AU - Carrano,Courtney, AU - Robbins,Steven J, AU - Hoffman,John R, Y1 - 2006/06/05/ PY - 2006/01/05/received PY - 2006/04/05/revised PY - 2006/04/18/accepted PY - 2006/6/3/pubmed PY - 2006/10/3/medline PY - 2006/6/3/entrez SP - 17 EP - 25 JF - Pharmacology, biochemistry, and behavior JO - Pharmacol Biochem Behav VL - 84 IS - 1 N2 - Ginkgo biloba is reported to improve learning and memory in animals. However, many studies do not directly test the effects of Ginkgo on memory because the drug is administered during the learning phase of the experiments. In this study, we examined the effect of 10 mg/kg, 20 mg/kg, or 40 mg/kg G. biloba extract on spatial memory by administering the drug in the interval between training and testing. Rats were tested for long-term reference memory retention in the radial arm maze and in the Morris water maze during daily probe trials in which the hidden platform was removed. G. biloba had no effect on reference memory in either the water maze or radial arm maze. To test short-term working spatial memory using the radial arm maze, animals were removed after receiving the reward from 4 of the 8 arms and were returned to complete the maze 2 h later. While Ginkgo had no effect on working memory, over time animals exposed to Ginkgo learned task better than control animals. Thus, Ginkgo appears to enhance neither short-term working memory nor long-term reference memory, but it may promote learning of spatial information. SN - 0091-3057 UR - https://www.unboundmedicine.com/medline/citation/16740301/Effects_of_Ginkgo_biloba_administered_after_spatial_learning_on_water_maze_and_radial_arm_maze_performance_in_young_adult_rats_ DB - PRIME DP - Unbound Medicine ER -