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Correlation between putative indicators of primary restless legs syndrome severity.
Sleep Med 2007; 8(1):84-9SM

Abstract

BACKGROUND AND PURPOSE

Several methods of assessing disease severity in restless legs syndrome (RLS) have been suggested. The purpose of this study was to examine the relationship between the suggested immobilization test (SIT), the International RLS Study Group rating scale (IRLS), sleep efficiency, and periodic leg movements of sleep index (PLMI).

PATIENTS AND METHODS

Forty primary RLS patients with periodic leg movements of sleep were included in this prospective study. Study procedures were all performed during the same night, beginning with IRLS administration and following with SIT and polysomnography (PSG) evaluations, in that order. SIT was composed of two parameters: SIT mean discomfort score (SIT-MDS) and SIT periodic leg movements of wakefulness index (SIT-PLMW). PSG target measures were PLMI and sleep efficiency. Pearson's correlation was used for analysis at a P<0.01 significance level.

RESULTS

PSG-PLMI correlated with IRLS (r=0.462; P=0.003) and with SIT-PLMW (r=0.681; P=0.0004). A correlation was also found between IRLS and SIT-MDS (r=0.447; P=0.004), even though SIT-PLMW and IRLS did not correlate with each other (P=0.286). A negative correlation was found between PSG-PLMI and sleep efficiency (r=-0.435; P=0.005). Neither SIT nor IRLS correlated with sleep efficiency. Only SIT discomfort scores from the second half of SIT correlated with SIT-PLMW (r=0.457, P=0.004), and they had a stronger correlation with IRLS (P=0.003).

CONCLUSIONS

This study attempted a much needed comprehensive evaluation of the relationship between various RLS severity indicators. Our findings support a strong role of motor dysfunction on sleep quality in RLS, as well as the potential use of SIT-PLMW as a sensitive indicator of RLS severity.

Authors+Show Affiliations

Neurology Department, Erciyes University Medical Faculty, 38039 Kayseri, Turkey. aksu@erciyes.edu.trNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16740410

Citation

Aksu, Murat, et al. "Correlation Between Putative Indicators of Primary Restless Legs Syndrome Severity." Sleep Medicine, vol. 8, no. 1, 2007, pp. 84-9.
Aksu M, Demirci S, Bara-Jimenez W. Correlation between putative indicators of primary restless legs syndrome severity. Sleep Med. 2007;8(1):84-9.
Aksu, M., Demirci, S., & Bara-Jimenez, W. (2007). Correlation between putative indicators of primary restless legs syndrome severity. Sleep Medicine, 8(1), pp. 84-9.
Aksu M, Demirci S, Bara-Jimenez W. Correlation Between Putative Indicators of Primary Restless Legs Syndrome Severity. Sleep Med. 2007;8(1):84-9. PubMed PMID: 16740410.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Correlation between putative indicators of primary restless legs syndrome severity. AU - Aksu,Murat, AU - Demirci,Sevda, AU - Bara-Jimenez,William, Y1 - 2006/06/05/ PY - 2005/03/07/received PY - 2005/11/08/revised PY - 2005/12/01/accepted PY - 2006/6/3/pubmed PY - 2007/4/21/medline PY - 2006/6/3/entrez SP - 84 EP - 9 JF - Sleep medicine JO - Sleep Med. VL - 8 IS - 1 N2 - BACKGROUND AND PURPOSE: Several methods of assessing disease severity in restless legs syndrome (RLS) have been suggested. The purpose of this study was to examine the relationship between the suggested immobilization test (SIT), the International RLS Study Group rating scale (IRLS), sleep efficiency, and periodic leg movements of sleep index (PLMI). PATIENTS AND METHODS: Forty primary RLS patients with periodic leg movements of sleep were included in this prospective study. Study procedures were all performed during the same night, beginning with IRLS administration and following with SIT and polysomnography (PSG) evaluations, in that order. SIT was composed of two parameters: SIT mean discomfort score (SIT-MDS) and SIT periodic leg movements of wakefulness index (SIT-PLMW). PSG target measures were PLMI and sleep efficiency. Pearson's correlation was used for analysis at a P<0.01 significance level. RESULTS: PSG-PLMI correlated with IRLS (r=0.462; P=0.003) and with SIT-PLMW (r=0.681; P=0.0004). A correlation was also found between IRLS and SIT-MDS (r=0.447; P=0.004), even though SIT-PLMW and IRLS did not correlate with each other (P=0.286). A negative correlation was found between PSG-PLMI and sleep efficiency (r=-0.435; P=0.005). Neither SIT nor IRLS correlated with sleep efficiency. Only SIT discomfort scores from the second half of SIT correlated with SIT-PLMW (r=0.457, P=0.004), and they had a stronger correlation with IRLS (P=0.003). CONCLUSIONS: This study attempted a much needed comprehensive evaluation of the relationship between various RLS severity indicators. Our findings support a strong role of motor dysfunction on sleep quality in RLS, as well as the potential use of SIT-PLMW as a sensitive indicator of RLS severity. SN - 1389-9457 UR - https://www.unboundmedicine.com/medline/citation/16740410/Correlation_between_putative_indicators_of_primary_restless_legs_syndrome_severity_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1389-9457(05)00310-2 DB - PRIME DP - Unbound Medicine ER -