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Large subcortical infarcts: clinical features, risk factors, and long-term prognosis compared with cortical and small deep infarcts.
Stroke. 2006 Jul; 37(7):1828-32.S

Abstract

BACKGROUND AND PURPOSE

In this study we compared risk factors, clinical features, and stroke recurrence in a large series of patients with large subcortical, cortical, or small deep infarcts.

METHODS

Patients with a transient or minor ischemic attack (modified Rankin Scale grade of < or =3) who had a single relevant supratentorial infarct of presumed noncardioembolic origin on CT were classified as suffering from a large subcortical (n=120), small deep (n=324), or cortical (n=211) infarct. Mean follow-up was 8 years. Rates of recurrent stroke were compared with Cox regression.

RESULTS

The clinical deficits caused by large subcortical infarcts resembled either those of a cortical or those of a small deep infarct. Risk factor profiles were similar in the 3 groups. The rate of recurrent stroke in patients with a large subcortical infarct (25/120; 21%) did not differ from that of patients with a cortical infarct (46/211; 22%) or with a small deep infarct (60/324; 19%). After adjustment for age, sex, and vascular risk factors, hazard ratios for recurrent stroke of large subcortical and cortical infarcts were 1.05 (95% CI, 0.65 to 1.70) and 1.17 (95% CI, 0.79 to 1.73), respectively, compared with small deep infarcts.

CONCLUSIONS

Clinical features, risk factor profiles, and stroke recurrence rate in patients with a large subcortical infarct only differ slightly from those in patients with small deep or cortical infarcts.

Authors+Show Affiliations

Halkes PH
Department of Neurology, Rudolf Magnus Institute, University Medical Center Utrecht, Utrecht, Netherlands. phalkes@umcutrecht.nl
Kappelle LJ
No affiliation info available
van Gijn J
No affiliation info available
van Wijk I
No affiliation info available
Koudstaal PJ
No affiliation info available
Algra A
No affiliation info available

MeSH

AdultAgedAged, 80 and overAspirinBrainCerebral CortexCerebral InfarctionCohort StudiesFemaleFollow-Up StudiesHumansIschemic Attack, TransientMaleMiddle AgedMulticenter Studies as TopicNetherlandsPlatelet Aggregation InhibitorsPrognosisProportional Hazards ModelsRandomized Controlled Trials as TopicRecurrenceRisk Factors

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16741175

Citation

Halkes, Patricia H A., et al. "Large Subcortical Infarcts: Clinical Features, Risk Factors, and Long-term Prognosis Compared With Cortical and Small Deep Infarcts." Stroke, vol. 37, no. 7, 2006, pp. 1828-32.
Halkes PH, Kappelle LJ, van Gijn J, et al. Large subcortical infarcts: clinical features, risk factors, and long-term prognosis compared with cortical and small deep infarcts. Stroke. 2006;37(7):1828-32.
Halkes, P. H., Kappelle, L. J., van Gijn, J., van Wijk, I., Koudstaal, P. J., & Algra, A. (2006). Large subcortical infarcts: clinical features, risk factors, and long-term prognosis compared with cortical and small deep infarcts. Stroke, 37(7), 1828-32.
Halkes PH, et al. Large Subcortical Infarcts: Clinical Features, Risk Factors, and Long-term Prognosis Compared With Cortical and Small Deep Infarcts. Stroke. 2006;37(7):1828-32. PubMed PMID: 16741175.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Large subcortical infarcts: clinical features, risk factors, and long-term prognosis compared with cortical and small deep infarcts. AU - Halkes,Patricia H A, AU - Kappelle,L Jaap, AU - van Gijn,Jan, AU - van Wijk,Iris, AU - Koudstaal,Peter J, AU - Algra,Ale, Y1 - 2006/06/01/ PY - 2006/6/3/pubmed PY - 2006/7/19/medline PY - 2006/6/3/entrez SP - 1828 EP - 32 JF - Stroke JO - Stroke VL - 37 IS - 7 N2 - BACKGROUND AND PURPOSE: In this study we compared risk factors, clinical features, and stroke recurrence in a large series of patients with large subcortical, cortical, or small deep infarcts. METHODS: Patients with a transient or minor ischemic attack (modified Rankin Scale grade of < or =3) who had a single relevant supratentorial infarct of presumed noncardioembolic origin on CT were classified as suffering from a large subcortical (n=120), small deep (n=324), or cortical (n=211) infarct. Mean follow-up was 8 years. Rates of recurrent stroke were compared with Cox regression. RESULTS: The clinical deficits caused by large subcortical infarcts resembled either those of a cortical or those of a small deep infarct. Risk factor profiles were similar in the 3 groups. The rate of recurrent stroke in patients with a large subcortical infarct (25/120; 21%) did not differ from that of patients with a cortical infarct (46/211; 22%) or with a small deep infarct (60/324; 19%). After adjustment for age, sex, and vascular risk factors, hazard ratios for recurrent stroke of large subcortical and cortical infarcts were 1.05 (95% CI, 0.65 to 1.70) and 1.17 (95% CI, 0.79 to 1.73), respectively, compared with small deep infarcts. CONCLUSIONS: Clinical features, risk factor profiles, and stroke recurrence rate in patients with a large subcortical infarct only differ slightly from those in patients with small deep or cortical infarcts. SN - 1524-4628 UR - https://www.unboundmedicine.com/medline/citation/16741175/Large_subcortical_infarcts:_clinical_features_risk_factors_and_long_term_prognosis_compared_with_cortical_and_small_deep_infarcts_ DB - PRIME DP - Unbound Medicine ER -