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Mantoux reaction in patients with HIV-related pulmonary tuberculosis in Maiduguri, Nigeria.
Afr J Med Med Sci. 2005 Jun; 34(2):125-8.AJ

Abstract

Tuberculin skin testing is used for the identification of individuals with infection by Mycobacterium tuberculosis and other non-tuberculous mycobacteria. However, its value in immunosuppressed individuals due to human immunodeficiency virus (HIV) infection is controversial. This study was aimed at determining the relationship between Mantoux reaction and CD4+ cell counts; and whether the test can be used to predict CD4+ counts in patients dually infected with Human Immunodeficiency Virus and M. tuberculosis. Eighty patients, comprising 42 males (52.5%) and 38 females (47.5%) confirmed to be having antibodies to HIV who also had sputum smear positive pulmonary tuberculosis were recruited over a period of 16 months. They were Mantoux-tested with 0.1 ml of 5TU of PPD which was interpreted thus: <5 mm = negative, =5 mm = positive. CD4+ counts were determined using Dynabeads technique. The ages of all the patients ranged between 18 and 55 years (mean +/- SD: 33.9+/-8.42 years). The males had a mean age of 35.4 +/- 7.7 years while that of the females was 29.6+/-53 years (P<0.05). The CD4+ counts ranged between 73 and 512 cells/microl with a mean of 235.05 +/- 112.8 cells/microl. Fifty seven (71%) patients had negative PPD tests while 23 (29%) tested positive. Of the 37 with CD4+ counts <200 cells/microl, 32 (86.48%) had negative reaction (<5 mm) and 5 (13.51%) were positive (=5 mm) as compared to those with CD4 counts =200 cells/microl, among whom 25 (58.13%) were negative and 18 (41.86%) were positive (P<0.05). The positive predictive value was low at 56.14%. The difference in mean indurations between those with CD4+ count <200 cells/microl versus those with CD4+ count =200 cells/microl was statistically significant (P<0.05). On the whole, Mantoux indurations were noted to weakly correlate positively with CD4+ counts (Pearson's correlation, r=+0.36, P=0.001. It was concluded that there is a weak positive correlation between Mantoux reaction and CD4+ cell counts and that the Mantoux test is a poor predictor of CD4+ cell count.

Authors+Show Affiliations

Department of Medicine, University of Maiduguri Teaching Hospital, Nigeria. harunayusuph@hotmail.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16749335

Citation

Yusuph, H, et al. "Mantoux Reaction in Patients With HIV-related Pulmonary Tuberculosis in Maiduguri, Nigeria." African Journal of Medicine and Medical Sciences, vol. 34, no. 2, 2005, pp. 125-8.
Yusuph H, Garbati MA, Gashau W. Mantoux reaction in patients with HIV-related pulmonary tuberculosis in Maiduguri, Nigeria. Afr J Med Med Sci. 2005;34(2):125-8.
Yusuph, H., Garbati, M. A., & Gashau, W. (2005). Mantoux reaction in patients with HIV-related pulmonary tuberculosis in Maiduguri, Nigeria. African Journal of Medicine and Medical Sciences, 34(2), 125-8.
Yusuph H, Garbati MA, Gashau W. Mantoux Reaction in Patients With HIV-related Pulmonary Tuberculosis in Maiduguri, Nigeria. Afr J Med Med Sci. 2005;34(2):125-8. PubMed PMID: 16749335.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mantoux reaction in patients with HIV-related pulmonary tuberculosis in Maiduguri, Nigeria. AU - Yusuph,H, AU - Garbati,M A, AU - Gashau,W, PY - 2006/6/6/pubmed PY - 2006/7/13/medline PY - 2006/6/6/entrez SP - 125 EP - 8 JF - African journal of medicine and medical sciences JO - Afr J Med Med Sci VL - 34 IS - 2 N2 - Tuberculin skin testing is used for the identification of individuals with infection by Mycobacterium tuberculosis and other non-tuberculous mycobacteria. However, its value in immunosuppressed individuals due to human immunodeficiency virus (HIV) infection is controversial. This study was aimed at determining the relationship between Mantoux reaction and CD4+ cell counts; and whether the test can be used to predict CD4+ counts in patients dually infected with Human Immunodeficiency Virus and M. tuberculosis. Eighty patients, comprising 42 males (52.5%) and 38 females (47.5%) confirmed to be having antibodies to HIV who also had sputum smear positive pulmonary tuberculosis were recruited over a period of 16 months. They were Mantoux-tested with 0.1 ml of 5TU of PPD which was interpreted thus: <5 mm = negative, =5 mm = positive. CD4+ counts were determined using Dynabeads technique. The ages of all the patients ranged between 18 and 55 years (mean +/- SD: 33.9+/-8.42 years). The males had a mean age of 35.4 +/- 7.7 years while that of the females was 29.6+/-53 years (P<0.05). The CD4+ counts ranged between 73 and 512 cells/microl with a mean of 235.05 +/- 112.8 cells/microl. Fifty seven (71%) patients had negative PPD tests while 23 (29%) tested positive. Of the 37 with CD4+ counts <200 cells/microl, 32 (86.48%) had negative reaction (<5 mm) and 5 (13.51%) were positive (=5 mm) as compared to those with CD4 counts =200 cells/microl, among whom 25 (58.13%) were negative and 18 (41.86%) were positive (P<0.05). The positive predictive value was low at 56.14%. The difference in mean indurations between those with CD4+ count <200 cells/microl versus those with CD4+ count =200 cells/microl was statistically significant (P<0.05). On the whole, Mantoux indurations were noted to weakly correlate positively with CD4+ counts (Pearson's correlation, r=+0.36, P=0.001. It was concluded that there is a weak positive correlation between Mantoux reaction and CD4+ cell counts and that the Mantoux test is a poor predictor of CD4+ cell count. SN - 0309-3913 UR - https://www.unboundmedicine.com/medline/citation/16749335/Mantoux_reaction_in_patients_with_HIV_related_pulmonary_tuberculosis_in_Maiduguri_Nigeria_ L2 - https://www.diseaseinfosearch.org/result/7252 DB - PRIME DP - Unbound Medicine ER -