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Efficacy and safety of a single botulinum type A toxin complex treatment (Dysport) for the relief of upper back myofascial pain syndrome: results from a randomized double-blind placebo-controlled multicentre study.
Pain. 2006 Nov; 125(1-2):82-8.PAIN

Abstract

Botulinum type A toxin (BoNT-A) has antinociceptive and muscle-relaxant properties and may help relieve the symptoms of myofascial pain syndrome. In this study we evaluated the efficacy and tolerability of BoNT-A (Dysport) in patients with myofascial pain syndrome of the upper back. We conducted a prospective, randomized, double-blind, placebo-controlled, 12-week, multicentre study. Patients with moderate-to-severe myofascial pain syndrome affecting cervical and/or shoulder muscles (10 trigger points, disease duration 6-24 months) were randomized to Dysport or saline. Injections were made into the 10 most tender trigger points (40 units per site). The primary outcome was the proportion of patients with mild or no pain at week 5. Secondary outcomes included changes in pain intensity and the number of pain-free days per week. Tolerability and safety were also assessed. At week 5, significantly more patients in the Dysport group reported mild or no pain (51%), compared with the patients in the placebo group (26%; p=0.002). Compared with placebo, Dysport resulted in a significantly greater change from baseline in pain intensity during weeks 5-8 (p<0.05), and significantly fewer days per week without pain between weeks 5 and 12 (p=0.036). Treatment was well tolerated, with most side effects resolving within 8 weeks. In conclusion, in patients with upper back myofascial pain syndrome, injections of 400 Ipsen units of Dysport at 10 individualised trigger points significantly improved pain levels 4-6 weeks after treatment. Injections were well tolerated.

Authors+Show Affiliations

Kiel Pain Centre, Heikendorfer Weg 9-27, 24149 Kiel, Germany. hg@schmerzklinik.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial

Language

eng

PubMed ID

16750294

Citation

Göbel, Hartmut, et al. "Efficacy and Safety of a Single Botulinum Type a Toxin Complex Treatment (Dysport) for the Relief of Upper Back Myofascial Pain Syndrome: Results From a Randomized Double-blind Placebo-controlled Multicentre Study." Pain, vol. 125, no. 1-2, 2006, pp. 82-8.
Göbel H, Heinze A, Reichel G, et al. Efficacy and safety of a single botulinum type A toxin complex treatment (Dysport) for the relief of upper back myofascial pain syndrome: results from a randomized double-blind placebo-controlled multicentre study. Pain. 2006;125(1-2):82-8.
Göbel, H., Heinze, A., Reichel, G., Hefter, H., & Benecke, R. (2006). Efficacy and safety of a single botulinum type A toxin complex treatment (Dysport) for the relief of upper back myofascial pain syndrome: results from a randomized double-blind placebo-controlled multicentre study. Pain, 125(1-2), 82-8.
Göbel H, et al. Efficacy and Safety of a Single Botulinum Type a Toxin Complex Treatment (Dysport) for the Relief of Upper Back Myofascial Pain Syndrome: Results From a Randomized Double-blind Placebo-controlled Multicentre Study. Pain. 2006;125(1-2):82-8. PubMed PMID: 16750294.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy and safety of a single botulinum type A toxin complex treatment (Dysport) for the relief of upper back myofascial pain syndrome: results from a randomized double-blind placebo-controlled multicentre study. AU - Göbel,Hartmut, AU - Heinze,Axel, AU - Reichel,Gerhard, AU - Hefter,Harald, AU - Benecke,Reiner, AU - ,, Y1 - 2006/06/05/ PY - 2006/01/18/received PY - 2006/04/18/revised PY - 2006/05/01/accepted PY - 2006/6/6/pubmed PY - 2006/11/10/medline PY - 2006/6/6/entrez SP - 82 EP - 8 JF - Pain JO - Pain VL - 125 IS - 1-2 N2 - Botulinum type A toxin (BoNT-A) has antinociceptive and muscle-relaxant properties and may help relieve the symptoms of myofascial pain syndrome. In this study we evaluated the efficacy and tolerability of BoNT-A (Dysport) in patients with myofascial pain syndrome of the upper back. We conducted a prospective, randomized, double-blind, placebo-controlled, 12-week, multicentre study. Patients with moderate-to-severe myofascial pain syndrome affecting cervical and/or shoulder muscles (10 trigger points, disease duration 6-24 months) were randomized to Dysport or saline. Injections were made into the 10 most tender trigger points (40 units per site). The primary outcome was the proportion of patients with mild or no pain at week 5. Secondary outcomes included changes in pain intensity and the number of pain-free days per week. Tolerability and safety were also assessed. At week 5, significantly more patients in the Dysport group reported mild or no pain (51%), compared with the patients in the placebo group (26%; p=0.002). Compared with placebo, Dysport resulted in a significantly greater change from baseline in pain intensity during weeks 5-8 (p<0.05), and significantly fewer days per week without pain between weeks 5 and 12 (p=0.036). Treatment was well tolerated, with most side effects resolving within 8 weeks. In conclusion, in patients with upper back myofascial pain syndrome, injections of 400 Ipsen units of Dysport at 10 individualised trigger points significantly improved pain levels 4-6 weeks after treatment. Injections were well tolerated. SN - 1872-6623 UR - https://www.unboundmedicine.com/medline/citation/16750294/Efficacy_and_safety_of_a_single_botulinum_type_A_toxin_complex_treatment__Dysport__for_the_relief_of_upper_back_myofascial_pain_syndrome:_results_from_a_randomized_double_blind_placebo_controlled_multicentre_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3959(06)00253-3 DB - PRIME DP - Unbound Medicine ER -