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Investigation and modelling approach of the mechanical properties of compacts made with binary mixtures of pharmaceutical excipients.
Eur J Pharm Biopharm. 2006 Aug; 64(1):51-65.EJ

Abstract

Three pharmaceutical excipients (microcrystalline cellulose, lactose, anhydrous calcium phosphate) and their binary mixtures were compacted to form compacts of various mean porosities. Some mechanical properties (Young's modulus, tensile strength and Brinell hardness) were studied on these compacts. The mechanical properties of the binary mixtures were not proportional to the mixture composition expressed in mass. More, for all the properties, a negative deviation was always observed from this linear relationship. In reference to a composition percolation phenomenon, critical mass fractions were detected from the graph mechanical property vs. mass composition of a mixture. The results obtained with Brinell hardness differed from the results of the Young's modulus and the tensile strength, i.e. the most plastic material in the binary mixture controlled the mixture behaviour. Secondly, a predictive model based on a statistical approach was proposed for the Young's modulus and the tensile strength. The validity of this model was verified on experimental data, and an interaction parameter used to characterize the affinity of the two compounds was calculated. Finally, the X-ray tomography technique was applied to the compacts of cellulose/phosphate mixtures to obtain cross-sections images of the compacts. The analysis of the cross-sections images allowed explaining the no linear relationship of the different mechanical properties results observed on these binary mixtures.

Authors+Show Affiliations

Busignies V
Centre d'études Pharmaceutiques de l'Université Paris XI, Châtenay-Malabry, France.
Leclerc B
No affiliation info available
Porion P
No affiliation info available
Evesque P
No affiliation info available
Couarraze G
No affiliation info available
Tchoreloff P
No affiliation info available

MeSH

CelluloseChemistry, PharmaceuticalDrug CompoundingDrug DesignExcipientsModels, ChemicalModels, TheoreticalPowdersStress, MechanicalTabletsTechnology, PharmaceuticalTensile StrengthTomography, X-Ray ComputedX-Rays

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16750353

Citation

Busignies, V, et al. "Investigation and Modelling Approach of the Mechanical Properties of Compacts Made With Binary Mixtures of Pharmaceutical Excipients." European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V, vol. 64, no. 1, 2006, pp. 51-65.
Busignies V, Leclerc B, Porion P, et al. Investigation and modelling approach of the mechanical properties of compacts made with binary mixtures of pharmaceutical excipients. Eur J Pharm Biopharm. 2006;64(1):51-65.
Busignies, V., Leclerc, B., Porion, P., Evesque, P., Couarraze, G., & Tchoreloff, P. (2006). Investigation and modelling approach of the mechanical properties of compacts made with binary mixtures of pharmaceutical excipients. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V, 64(1), 51-65.
Busignies V, et al. Investigation and Modelling Approach of the Mechanical Properties of Compacts Made With Binary Mixtures of Pharmaceutical Excipients. Eur J Pharm Biopharm. 2006;64(1):51-65. PubMed PMID: 16750353.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Investigation and modelling approach of the mechanical properties of compacts made with binary mixtures of pharmaceutical excipients. AU - Busignies,V, AU - Leclerc,B, AU - Porion,P, AU - Evesque,P, AU - Couarraze,G, AU - Tchoreloff,P, Y1 - 2006/06/05/ PY - 2006/01/24/received PY - 2006/03/15/revised PY - 2006/03/16/accepted PY - 2006/6/6/pubmed PY - 2007/1/17/medline PY - 2006/6/6/entrez SP - 51 EP - 65 JF - European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V JO - Eur J Pharm Biopharm VL - 64 IS - 1 N2 - Three pharmaceutical excipients (microcrystalline cellulose, lactose, anhydrous calcium phosphate) and their binary mixtures were compacted to form compacts of various mean porosities. Some mechanical properties (Young's modulus, tensile strength and Brinell hardness) were studied on these compacts. The mechanical properties of the binary mixtures were not proportional to the mixture composition expressed in mass. More, for all the properties, a negative deviation was always observed from this linear relationship. In reference to a composition percolation phenomenon, critical mass fractions were detected from the graph mechanical property vs. mass composition of a mixture. The results obtained with Brinell hardness differed from the results of the Young's modulus and the tensile strength, i.e. the most plastic material in the binary mixture controlled the mixture behaviour. Secondly, a predictive model based on a statistical approach was proposed for the Young's modulus and the tensile strength. The validity of this model was verified on experimental data, and an interaction parameter used to characterize the affinity of the two compounds was calculated. Finally, the X-ray tomography technique was applied to the compacts of cellulose/phosphate mixtures to obtain cross-sections images of the compacts. The analysis of the cross-sections images allowed explaining the no linear relationship of the different mechanical properties results observed on these binary mixtures. SN - 0939-6411 UR - https://www.unboundmedicine.com/medline/citation/16750353/Investigation_and_modelling_approach_of_the_mechanical_properties_of_compacts_made_with_binary_mixtures_of_pharmaceutical_excipients_ DB - PRIME DP - Unbound Medicine ER -