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Preparation of a solid dispersion of felodipine using a solvent wetting method.
Eur J Pharm Biopharm. 2006 Oct; 64(2):200-5.EJ

Abstract

A straightforward solvent wetting method was used to prepare felodipine solid dispersions in the presence of various carriers. Dichloromethane is not needed when HPMC solid dispersions were produced using the solvent wetting method. The amount of ethanol used to prepare solid dispersions did not have a significant effect on the dissolution rate of felodipine. The results of X-ray diffraction and thermal analysis indicated that the drug was in the amorphous state when PVP, HPMC, and poloxamer were used as carriers. The dissolution rates of felodipine in PVP, HPMC, or poloxamer solid dispersions were much faster than those for the corresponding physical mixtures. However, dissolution profiles were found to depend on the carrier used; the dissolution rate of felodipine increased slowly for solid dispersions prepared using HPMC, whereas rapid initial dissolution rates were observed for solid dispersions prepared using PVP or poloxamer. Increases in dissolution rates were partly dependent on the ratios of felodipine to carrier. No significant changes in crystal form were observed by X-ray diffraction or thermal analysis, and no significant changes in dissolution rate were observed when sorbitol and mannitol were used as carriers.

Authors+Show Affiliations

College of Pharmacy, Chosun University, Gwangju, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16750355

Citation

Kim, Eun-Jung, et al. "Preparation of a Solid Dispersion of Felodipine Using a Solvent Wetting Method." European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V, vol. 64, no. 2, 2006, pp. 200-5.
Kim EJ, Chun MK, Jang JS, et al. Preparation of a solid dispersion of felodipine using a solvent wetting method. Eur J Pharm Biopharm. 2006;64(2):200-5.
Kim, E. J., Chun, M. K., Jang, J. S., Lee, I. H., Lee, K. R., & Choi, H. K. (2006). Preparation of a solid dispersion of felodipine using a solvent wetting method. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V, 64(2), 200-5.
Kim EJ, et al. Preparation of a Solid Dispersion of Felodipine Using a Solvent Wetting Method. Eur J Pharm Biopharm. 2006;64(2):200-5. PubMed PMID: 16750355.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preparation of a solid dispersion of felodipine using a solvent wetting method. AU - Kim,Eun-Jung, AU - Chun,Myung-Kwan, AU - Jang,Jae-Sang, AU - Lee,In-Hwa, AU - Lee,Kyeo-Re, AU - Choi,Hoo-Kyun, Y1 - 2006/04/27/ PY - 2006/01/10/received PY - 2006/03/28/revised PY - 2006/04/21/accepted PY - 2006/6/6/pubmed PY - 2007/2/10/medline PY - 2006/6/6/entrez SP - 200 EP - 5 JF - European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V JO - Eur J Pharm Biopharm VL - 64 IS - 2 N2 - A straightforward solvent wetting method was used to prepare felodipine solid dispersions in the presence of various carriers. Dichloromethane is not needed when HPMC solid dispersions were produced using the solvent wetting method. The amount of ethanol used to prepare solid dispersions did not have a significant effect on the dissolution rate of felodipine. The results of X-ray diffraction and thermal analysis indicated that the drug was in the amorphous state when PVP, HPMC, and poloxamer were used as carriers. The dissolution rates of felodipine in PVP, HPMC, or poloxamer solid dispersions were much faster than those for the corresponding physical mixtures. However, dissolution profiles were found to depend on the carrier used; the dissolution rate of felodipine increased slowly for solid dispersions prepared using HPMC, whereas rapid initial dissolution rates were observed for solid dispersions prepared using PVP or poloxamer. Increases in dissolution rates were partly dependent on the ratios of felodipine to carrier. No significant changes in crystal form were observed by X-ray diffraction or thermal analysis, and no significant changes in dissolution rate were observed when sorbitol and mannitol were used as carriers. SN - 0939-6411 UR - https://www.unboundmedicine.com/medline/citation/16750355/Preparation_of_a_solid_dispersion_of_felodipine_using_a_solvent_wetting_method_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-6411(06)00084-1 DB - PRIME DP - Unbound Medicine ER -