Evaluation of indenoisoquinoline topoisomerase I inhibitors using a hollow fiber assay.Bioorg Med Chem Lett. 2006 Aug 15; 16(16):4395-9.BM
Abstract
The indenoisoquinolines are a novel class of non-camptothecin topoisomerase I (Top1) inhibitors whose mechanism of action involves trapping the covalent complex formed between DNA and Top1 during cellular processes. As an ongoing evaluation of the indenoisoquinolines for Top1 inhibition and anticancer activity, indenoisoquinoline analogs have been screened in the National Cancer Institute's hollow fiber assay (HFA). Some of the derivatives demonstrated significant activity at intraperitoneal and subcutaneous fiber placement sites, along with net cancer cell kill in one or more cell lines.
Links
MeSH
Pub Type(s)
Journal Article
Research Support, N.I.H., Extramural
Language
eng
PubMed ID
16750365
Citation
Morrell, Andrew, et al. "Evaluation of Indenoisoquinoline Topoisomerase I Inhibitors Using a Hollow Fiber Assay." Bioorganic & Medicinal Chemistry Letters, vol. 16, no. 16, 2006, pp. 4395-9.
Morrell A, Jayaraman M, Nagarajan M, et al. Evaluation of indenoisoquinoline topoisomerase I inhibitors using a hollow fiber assay. Bioorg Med Chem Lett. 2006;16(16):4395-9.
Morrell, A., Jayaraman, M., Nagarajan, M., Fox, B. M., Meckley, M. R., Ioanoviciu, A., Pommier, Y., Antony, S., Hollingshead, M., & Cushman, M. (2006). Evaluation of indenoisoquinoline topoisomerase I inhibitors using a hollow fiber assay. Bioorganic & Medicinal Chemistry Letters, 16(16), 4395-9.
Morrell A, et al. Evaluation of Indenoisoquinoline Topoisomerase I Inhibitors Using a Hollow Fiber Assay. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4395-9. PubMed PMID: 16750365.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR
T1 - Evaluation of indenoisoquinoline topoisomerase I inhibitors using a hollow fiber assay.
AU - Morrell,Andrew,
AU - Jayaraman,Muthusamy,
AU - Nagarajan,Muthukaman,
AU - Fox,Brian M,
AU - Meckley,Marintha Rae,
AU - Ioanoviciu,Alexandra,
AU - Pommier,Yves,
AU - Antony,Smitha,
AU - Hollingshead,Melinda,
AU - Cushman,Mark,
Y1 - 2006/06/05/
PY - 2006/04/12/received
PY - 2006/05/11/revised
PY - 2006/05/15/accepted
PY - 2006/6/6/pubmed
PY - 2006/10/7/medline
PY - 2006/6/6/entrez
SP - 4395
EP - 9
JF - Bioorganic & medicinal chemistry letters
JO - Bioorg Med Chem Lett
VL - 16
IS - 16
N2 - The indenoisoquinolines are a novel class of non-camptothecin topoisomerase I (Top1) inhibitors whose mechanism of action involves trapping the covalent complex formed between DNA and Top1 during cellular processes. As an ongoing evaluation of the indenoisoquinolines for Top1 inhibition and anticancer activity, indenoisoquinoline analogs have been screened in the National Cancer Institute's hollow fiber assay (HFA). Some of the derivatives demonstrated significant activity at intraperitoneal and subcutaneous fiber placement sites, along with net cancer cell kill in one or more cell lines.
SN - 0960-894X
UR - https://www.unboundmedicine.com/medline/citation/16750365/Evaluation_of_indenoisoquinoline_topoisomerase_I_inhibitors_using_a_hollow_fiber_assay_
L2 - https://linkinghub.elsevier.com/retrieve/pii/S0960-894X(06)00586-5
DB - PRIME
DP - Unbound Medicine
ER -