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Porin of Shigella dysenteriae activates mouse peritoneal macrophage through Toll-like receptors 2 and 6 to induce polarized type I response.
Mol Immunol. 2007 Feb; 44(5):812-20.MI

Abstract

Porin of Shigella dysenteriae type 1 coexpressed Toll-like receptor (TLR) 2 and TLR6 on peritoneal cavity (PerC) macrophages (MPhi) of C57BL/6 mice implicating that both the TLRs are essential as a combinatorial repertoire to recognize the protein. Besides TLRs, mRNA for MyD88 and TRAF6, and nuclear translocation of NF-kappaB were enhanced that indicate their involvement in tandem in the activity of porin. The protein selectively up-regulated CD80 on the activated MPhi together with MHC class II molecule and CD40, and had no effect on CD86 expression. The porin-induced profile of MIP-1alpha, MIP-1beta and RANTES showed strong bias for chemokines correlated with M1 polarization. Intracellular expression and release of TNF-alpha and IL-12 in presence of porin was found to be TLR2 and NF-kappaB dependent. Induction of TNF-alpha and IL-12 along with the chemokine profile suggests type I polarization of the MPhi that would influence Th1-type response.

Authors+Show Affiliations

Division of Immunology and Vaccine Development, National Institute of Cholera and Enteric Diseases, P-33 C.I.T. Road, Scheme XM, Kolkata-700 010, West Bengal, India.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16750567

Citation

Biswas, Amlan, et al. "Porin of Shigella Dysenteriae Activates Mouse Peritoneal Macrophage Through Toll-like Receptors 2 and 6 to Induce Polarized Type I Response." Molecular Immunology, vol. 44, no. 5, 2007, pp. 812-20.
Biswas A, Banerjee P, Mukherjee G, et al. Porin of Shigella dysenteriae activates mouse peritoneal macrophage through Toll-like receptors 2 and 6 to induce polarized type I response. Mol Immunol. 2007;44(5):812-20.
Biswas, A., Banerjee, P., Mukherjee, G., & Biswas, T. (2007). Porin of Shigella dysenteriae activates mouse peritoneal macrophage through Toll-like receptors 2 and 6 to induce polarized type I response. Molecular Immunology, 44(5), 812-20.
Biswas A, et al. Porin of Shigella Dysenteriae Activates Mouse Peritoneal Macrophage Through Toll-like Receptors 2 and 6 to Induce Polarized Type I Response. Mol Immunol. 2007;44(5):812-20. PubMed PMID: 16750567.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Porin of Shigella dysenteriae activates mouse peritoneal macrophage through Toll-like receptors 2 and 6 to induce polarized type I response. AU - Biswas,Amlan, AU - Banerjee,Pallavi, AU - Mukherjee,Gayatri, AU - Biswas,Tapas, Y1 - 2006/06/05/ PY - 2006/03/17/received PY - 2006/04/07/revised PY - 2006/04/10/accepted PY - 2006/6/6/pubmed PY - 2007/3/6/medline PY - 2006/6/6/entrez SP - 812 EP - 20 JF - Molecular immunology JO - Mol Immunol VL - 44 IS - 5 N2 - Porin of Shigella dysenteriae type 1 coexpressed Toll-like receptor (TLR) 2 and TLR6 on peritoneal cavity (PerC) macrophages (MPhi) of C57BL/6 mice implicating that both the TLRs are essential as a combinatorial repertoire to recognize the protein. Besides TLRs, mRNA for MyD88 and TRAF6, and nuclear translocation of NF-kappaB were enhanced that indicate their involvement in tandem in the activity of porin. The protein selectively up-regulated CD80 on the activated MPhi together with MHC class II molecule and CD40, and had no effect on CD86 expression. The porin-induced profile of MIP-1alpha, MIP-1beta and RANTES showed strong bias for chemokines correlated with M1 polarization. Intracellular expression and release of TNF-alpha and IL-12 in presence of porin was found to be TLR2 and NF-kappaB dependent. Induction of TNF-alpha and IL-12 along with the chemokine profile suggests type I polarization of the MPhi that would influence Th1-type response. SN - 0161-5890 UR - https://www.unboundmedicine.com/medline/citation/16750567/Porin_of_Shigella_dysenteriae_activates_mouse_peritoneal_macrophage_through_Toll_like_receptors_2_and_6_to_induce_polarized_type_I_response_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-5890(06)00155-6 DB - PRIME DP - Unbound Medicine ER -