Tags

Type your tag names separated by a space and hit enter

Effects of melatonin on lipid peroxidation and antioxidant enzymes in streptozotocin-induced diabetic rat testis.
Asian J Androl. 2006 Sep; 8(5):595-600.AJ

Abstract

AIM

To examine the effects of melatonin treatment on lipid peroxidation (LPO) and the activities of antioxidant enzymes in the testicular tissue of streptozotocin (STZ)-induced diabetic rats.

METHODS

Twenty-six male rats were randomly divided into three groups as follows: group I, control, non-diabetic rats (n = 9); group II, STZ-induced, untreated diabetic rats (n = 8); group III, STZ-induced, melatonin-treated (dose of 10 mg/kg . day) diabetic rats (n = 9). Following 8-week melatonin treatment, all rats were anaesthetized and then were killed to remove testes from the scrotum.

RESULTS

As compared to group I, in rat testicular tissues of group II , increased levels of malondialdehyde (MDA) (P < 0.01) and superoxide dismutase (SOD) (P < 0.01) as well as decreased levels of catalase (CAT) (P < 0.01) and glutathione peroxidase (GSH-Px) (P > 0.05) were found. In contrast, as compared to group II, in rat testicular tissues of group III, levels of MDA decreased (but this decrease was not significant, P > 0.05) and SOD (P < 0.01) as well as CAT (P < 0.05) increased. GSH-Px was not influenced by any of the treatment. Melatonin did not significantly affect the elevated glucose concentration of diabetic group. At the end of the study, there was no significant difference between the melatonin-treated group and the untreated group by means of body and testicular weight.

CONCLUSION

Diabetes mellitus increases oxidative stress and melatonin inhibits lipid peroxidation and might regulate the activities of antioxidant enzymes of diabetic rat testes.

Authors+Show Affiliations

Department of Urology, Suleyman Demirel University, Faculty of Medicine, Isparta 32050, Turkey. aarmagan@med.sdu.edu.trNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16752005

Citation

Armagan, Abdullah, et al. "Effects of Melatonin On Lipid Peroxidation and Antioxidant Enzymes in Streptozotocin-induced Diabetic Rat Testis." Asian Journal of Andrology, vol. 8, no. 5, 2006, pp. 595-600.
Armagan A, Uz E, Yilmaz HR, et al. Effects of melatonin on lipid peroxidation and antioxidant enzymes in streptozotocin-induced diabetic rat testis. Asian J Androl. 2006;8(5):595-600.
Armagan, A., Uz, E., Yilmaz, H. R., Soyupek, S., Oksay, T., & Ozcelik, N. (2006). Effects of melatonin on lipid peroxidation and antioxidant enzymes in streptozotocin-induced diabetic rat testis. Asian Journal of Andrology, 8(5), 595-600.
Armagan A, et al. Effects of Melatonin On Lipid Peroxidation and Antioxidant Enzymes in Streptozotocin-induced Diabetic Rat Testis. Asian J Androl. 2006;8(5):595-600. PubMed PMID: 16752005.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of melatonin on lipid peroxidation and antioxidant enzymes in streptozotocin-induced diabetic rat testis. AU - Armagan,Abdullah, AU - Uz,Efkan, AU - Yilmaz,H Ramazan, AU - Soyupek,Sedat, AU - Oksay,Taylan, AU - Ozcelik,Nurten, Y1 - 2006/06/05/ PY - 2006/6/6/pubmed PY - 2006/10/27/medline PY - 2006/6/6/entrez SP - 595 EP - 600 JF - Asian journal of andrology JO - Asian J. Androl. VL - 8 IS - 5 N2 - AIM: To examine the effects of melatonin treatment on lipid peroxidation (LPO) and the activities of antioxidant enzymes in the testicular tissue of streptozotocin (STZ)-induced diabetic rats. METHODS: Twenty-six male rats were randomly divided into three groups as follows: group I, control, non-diabetic rats (n = 9); group II, STZ-induced, untreated diabetic rats (n = 8); group III, STZ-induced, melatonin-treated (dose of 10 mg/kg . day) diabetic rats (n = 9). Following 8-week melatonin treatment, all rats were anaesthetized and then were killed to remove testes from the scrotum. RESULTS: As compared to group I, in rat testicular tissues of group II , increased levels of malondialdehyde (MDA) (P < 0.01) and superoxide dismutase (SOD) (P < 0.01) as well as decreased levels of catalase (CAT) (P < 0.01) and glutathione peroxidase (GSH-Px) (P > 0.05) were found. In contrast, as compared to group II, in rat testicular tissues of group III, levels of MDA decreased (but this decrease was not significant, P > 0.05) and SOD (P < 0.01) as well as CAT (P < 0.05) increased. GSH-Px was not influenced by any of the treatment. Melatonin did not significantly affect the elevated glucose concentration of diabetic group. At the end of the study, there was no significant difference between the melatonin-treated group and the untreated group by means of body and testicular weight. CONCLUSION: Diabetes mellitus increases oxidative stress and melatonin inhibits lipid peroxidation and might regulate the activities of antioxidant enzymes of diabetic rat testes. SN - 1008-682X UR - https://www.unboundmedicine.com/medline/citation/16752005/Effects_of_melatonin_on_lipid_peroxidation_and_antioxidant_enzymes_in_streptozotocin_induced_diabetic_rat_testis_ L2 - http://www.asiaandro.com/Abstract.asp?doi=10.1111/j.1745-7262.2006.00177.x DB - PRIME DP - Unbound Medicine ER -