Tags

Type your tag names separated by a space and hit enter

Efficacy and tolerability of celecoxib compared with diclofenac slow release in the treatment of acute ankle sprain in an Asian population.
Singapore Med J. 2006 Jun; 47(6):534-42.SM

Abstract

INTRODUCTION

Cyclooxygenase (COX)-2 selective inhibitors are attractive candidates for treatment of ankle sprain because of their efficacy as anti-inflammatory and analgesic agents and their overall safety, including lack of effect on platelet aggregation. The objective of this study was to assess the efficacy and tolerability of celecoxib compared with diclofenac slow release (SR) in the treatment of acute ankle sprain in an Asian population.

METHODS

In this seven-day, multicentre, double-blind, randomised, parallel-group trial, 370 patients with first- or second-degree ankle sprain occurring at or less than 48 hours prior to the first dose of study medication were randomised to receive celecoxib 200 mg bid (189 patients) after a 400 mg loading dose or diclofenac SR 75 mg bid (181 patients). Patients were required to demonstrate moderate to severe ankle pain on weight bearing (45 mm or greater on a 100 mm visual analogue scale [VAS]) at baseline. The primary efficacy end point was the patient's assessment of ankle pain (VAS on full weight bearing) on day 4.

RESULTS

Celecoxib was as effective as diclofenac SR in improving the signs and symptoms of ankle sprain. At day 4, mean VAS scores for celecoxib and diclofenac SR had decreased to 28 mm and 30 mm, respectively. Treatment differences were not statistically significant. Incidence of upper gastrointestinal adverse events was low in both treatment groups (0.5 percent versus 2.2 percent for celecoxib and diclofenac SR, respectively).

CONCLUSION

Celecoxib, a COX-2 selective inhibitor, is as effective as diclofenac SR in treating ankle sprains. With its platelet-sparing properties, celecoxib may offer an advantage over diclofenac SR in managing musculoskeletal injuries.

Authors+Show Affiliations

Armed Forces Hospital, Kem Terendak, Malacca 76200, Malaysia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16752024

Citation

Nadarajah, A, et al. "Efficacy and Tolerability of Celecoxib Compared With Diclofenac Slow Release in the Treatment of Acute Ankle Sprain in an Asian Population." Singapore Medical Journal, vol. 47, no. 6, 2006, pp. 534-42.
Nadarajah A, Abrahan L, Lau FL, et al. Efficacy and tolerability of celecoxib compared with diclofenac slow release in the treatment of acute ankle sprain in an Asian population. Singapore Med J. 2006;47(6):534-42.
Nadarajah, A., Abrahan, L., Lau, F. L., Hwang, L. J., & Fakir-Bolte, C. (2006). Efficacy and tolerability of celecoxib compared with diclofenac slow release in the treatment of acute ankle sprain in an Asian population. Singapore Medical Journal, 47(6), 534-42.
Nadarajah A, et al. Efficacy and Tolerability of Celecoxib Compared With Diclofenac Slow Release in the Treatment of Acute Ankle Sprain in an Asian Population. Singapore Med J. 2006;47(6):534-42. PubMed PMID: 16752024.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy and tolerability of celecoxib compared with diclofenac slow release in the treatment of acute ankle sprain in an Asian population. AU - Nadarajah,A, AU - Abrahan,L, AU - Lau,F L, AU - Hwang,L J, AU - Fakir-Bolte,C, PY - 2006/6/6/pubmed PY - 2006/8/2/medline PY - 2006/6/6/entrez SP - 534 EP - 42 JF - Singapore medical journal JO - Singapore Med J VL - 47 IS - 6 N2 - INTRODUCTION: Cyclooxygenase (COX)-2 selective inhibitors are attractive candidates for treatment of ankle sprain because of their efficacy as anti-inflammatory and analgesic agents and their overall safety, including lack of effect on platelet aggregation. The objective of this study was to assess the efficacy and tolerability of celecoxib compared with diclofenac slow release (SR) in the treatment of acute ankle sprain in an Asian population. METHODS: In this seven-day, multicentre, double-blind, randomised, parallel-group trial, 370 patients with first- or second-degree ankle sprain occurring at or less than 48 hours prior to the first dose of study medication were randomised to receive celecoxib 200 mg bid (189 patients) after a 400 mg loading dose or diclofenac SR 75 mg bid (181 patients). Patients were required to demonstrate moderate to severe ankle pain on weight bearing (45 mm or greater on a 100 mm visual analogue scale [VAS]) at baseline. The primary efficacy end point was the patient's assessment of ankle pain (VAS on full weight bearing) on day 4. RESULTS: Celecoxib was as effective as diclofenac SR in improving the signs and symptoms of ankle sprain. At day 4, mean VAS scores for celecoxib and diclofenac SR had decreased to 28 mm and 30 mm, respectively. Treatment differences were not statistically significant. Incidence of upper gastrointestinal adverse events was low in both treatment groups (0.5 percent versus 2.2 percent for celecoxib and diclofenac SR, respectively). CONCLUSION: Celecoxib, a COX-2 selective inhibitor, is as effective as diclofenac SR in treating ankle sprains. With its platelet-sparing properties, celecoxib may offer an advantage over diclofenac SR in managing musculoskeletal injuries. SN - 0037-5675 UR - https://www.unboundmedicine.com/medline/citation/16752024/Efficacy_and_tolerability_of_celecoxib_compared_with_diclofenac_slow_release_in_the_treatment_of_acute_ankle_sprain_in_an_Asian_population_ L2 - http://www.sma.org.sg/smj/4706/4706a11.pdf DB - PRIME DP - Unbound Medicine ER -