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Preserved microcirculatory response to acute estrogen not reflected by exercise capacity.
Acta Obstet Gynecol Scand. 2006; 85(6):736-40.AO

Abstract

BACKGROUND

To assess the acute effect of a single dose of 10 mg oral micronized 17beta-estradiol on microcirculation in postmenopausal women with and without coronary artery disease and its potential influence on exercise capacity.

METHODS

Postmenopausal women (n=11) with coronary artery disease had symptoms of ischemic heart disease and at least 1 mm ST depression at exercise. Microcirculation was examined by vital microscopy, with and without the acute administration of estrogen in a placebo-controlled cross-over design. Exercise test was performed on bicycle. The microcirculatory findings were contrasted to those in 14 healthy postmenopausal women.

RESULTS

17Beta-estradiol in serum and blood flow velocity increased significantly after acute oral estrogen administration both in women with coronary artery disease (p<0.001) and in healthy women (p<0.0001), with no significant difference between the two groups. No effect on exercise capacity or ST depression at exercise was detected.

CONCLUSIONS

Previously reported data that a single dose of estrogen administered to postmenopausal women results in positive effects on exercise was not reproduced. An increased peripheral microvascular flow velocity was detected in women with coronary artery disease and this increase was not accompanied by an increased exercise capacity.

Authors+Show Affiliations

Fogelberg M
Department of Medicine, Ersta Hospital, Stockholm, Sweden.
Löfman I
No affiliation info available
Carlström K
No affiliation info available
Freyschuss A
No affiliation info available
Henriksson P
No affiliation info available

MeSH

Administration, OralAgedBlood Flow VelocityCapillariesCoronary Artery DiseaseCross-Over StudiesEstradiolExercise TestExercise ToleranceFemaleFibrinogenHumansMicrocirculationMiddle AgedPostmenopauseReproducibility of Results

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16752268

Citation

Fogelberg, Monika, et al. "Preserved Microcirculatory Response to Acute Estrogen Not Reflected By Exercise Capacity." Acta Obstetricia Et Gynecologica Scandinavica, vol. 85, no. 6, 2006, pp. 736-40.
Fogelberg M, Löfman I, Carlström K, et al. Preserved microcirculatory response to acute estrogen not reflected by exercise capacity. Acta Obstet Gynecol Scand. 2006;85(6):736-40.
Fogelberg, M., Löfman, I., Carlström, K., Freyschuss, A., & Henriksson, P. (2006). Preserved microcirculatory response to acute estrogen not reflected by exercise capacity. Acta Obstetricia Et Gynecologica Scandinavica, 85(6), 736-40.
Fogelberg M, et al. Preserved Microcirculatory Response to Acute Estrogen Not Reflected By Exercise Capacity. Acta Obstet Gynecol Scand. 2006;85(6):736-40. PubMed PMID: 16752268.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preserved microcirculatory response to acute estrogen not reflected by exercise capacity. AU - Fogelberg,Monika, AU - Löfman,Ida, AU - Carlström,Kjell, AU - Freyschuss,Anna, AU - Henriksson,Peter, PY - 2006/6/6/pubmed PY - 2006/7/26/medline PY - 2006/6/6/entrez SP - 736 EP - 40 JF - Acta obstetricia et gynecologica Scandinavica JO - Acta Obstet Gynecol Scand VL - 85 IS - 6 N2 - BACKGROUND: To assess the acute effect of a single dose of 10 mg oral micronized 17beta-estradiol on microcirculation in postmenopausal women with and without coronary artery disease and its potential influence on exercise capacity. METHODS: Postmenopausal women (n=11) with coronary artery disease had symptoms of ischemic heart disease and at least 1 mm ST depression at exercise. Microcirculation was examined by vital microscopy, with and without the acute administration of estrogen in a placebo-controlled cross-over design. Exercise test was performed on bicycle. The microcirculatory findings were contrasted to those in 14 healthy postmenopausal women. RESULTS: 17Beta-estradiol in serum and blood flow velocity increased significantly after acute oral estrogen administration both in women with coronary artery disease (p<0.001) and in healthy women (p<0.0001), with no significant difference between the two groups. No effect on exercise capacity or ST depression at exercise was detected. CONCLUSIONS: Previously reported data that a single dose of estrogen administered to postmenopausal women results in positive effects on exercise was not reproduced. An increased peripheral microvascular flow velocity was detected in women with coronary artery disease and this increase was not accompanied by an increased exercise capacity. SN - 0001-6349 UR - https://www.unboundmedicine.com/medline/citation/16752268/Preserved_microcirculatory_response_to_acute_estrogen_not_reflected_by_exercise_capacity_ DB - PRIME DP - Unbound Medicine ER -