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Impact of cardiac surgery on plasma levels of B-type natriuretic peptide in children with congenital heart disease.
Int J Cardiol. 2007 Jan 18; 114(3):339-44.IJ

Abstract

OBJECTIVE

To examine prospectively the effect of cardiac surgery on plasma concentration of B-type natriuretic peptide (BNP) in children with congenital heart disease.

SETTING

Tertiary referral center.

METHODS

BNP plasma concentration was measured by sandwich immunoassay (Biosite) in 65 consecutive patients with congenital heart disease (age 4 days to 17.1 years, mean (S.D.) age 3.6 (4.7) years, median age 1.0 years) on the day before and after surgical therapy. BNP levels were compared to perioperative data and to healthy subjects.

RESULTS

BNP increased significantly (p<0.001) after cardiac surgery from median 31 pg/ml (mean 189 pg/ml) to median 453 pg/ml (mean 607 pg/ml) and remained significantly elevated during the first week (p<0.001). After a first peak mean (S.D.) 1.3 (0.7) days after surgery, there was a significant decrease of plasma BNP followed by a second peak 5.1 (1.1) days after surgery. Postoperative BNP plasma concentration was correlated to BNP before surgery (r=0.58, p<0.001), to cardiopulmonary bypass duration (r=0.52, p<0.001) and to serum lactate concentration at the first day after surgery (r=0.49, p<0.001).

CONCLUSIONS

In children with congenital heart defects plasma BNP increased immediately after cardiac surgery despite haemodynamic unloading. The correlation to cardiopulmonary bypass time and serum lactate concentration and the similarity between the pattern of BNP release after surgery and after myocardial ischaemia might be explained by a cytoprotective role for BNP after cardiac surgery.

Authors+Show Affiliations

Paediatric Cardiology, Department of Paediatrics and Adolescent Medicine, University of Erlangen-Nürnberg, Germany. Andreas.Koch@kinder.imed.uni-erlangen.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16753233

Citation

Koch, Andreas, et al. "Impact of Cardiac Surgery On Plasma Levels of B-type Natriuretic Peptide in Children With Congenital Heart Disease." International Journal of Cardiology, vol. 114, no. 3, 2007, pp. 339-44.
Koch A, Kitzsteiner T, Zink S, et al. Impact of cardiac surgery on plasma levels of B-type natriuretic peptide in children with congenital heart disease. Int J Cardiol. 2007;114(3):339-44.
Koch, A., Kitzsteiner, T., Zink, S., Cesnjevar, R., & Singer, H. (2007). Impact of cardiac surgery on plasma levels of B-type natriuretic peptide in children with congenital heart disease. International Journal of Cardiology, 114(3), 339-44.
Koch A, et al. Impact of Cardiac Surgery On Plasma Levels of B-type Natriuretic Peptide in Children With Congenital Heart Disease. Int J Cardiol. 2007 Jan 18;114(3):339-44. PubMed PMID: 16753233.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of cardiac surgery on plasma levels of B-type natriuretic peptide in children with congenital heart disease. AU - Koch,Andreas, AU - Kitzsteiner,Tobias, AU - Zink,Stefan, AU - Cesnjevar,Robert, AU - Singer,Helmut, Y1 - 2006/06/06/ PY - 2005/10/07/received PY - 2006/01/19/revised PY - 2006/01/27/accepted PY - 2006/6/7/pubmed PY - 2007/1/31/medline PY - 2006/6/7/entrez SP - 339 EP - 44 JF - International journal of cardiology JO - Int. J. Cardiol. VL - 114 IS - 3 N2 - OBJECTIVE: To examine prospectively the effect of cardiac surgery on plasma concentration of B-type natriuretic peptide (BNP) in children with congenital heart disease. SETTING: Tertiary referral center. METHODS: BNP plasma concentration was measured by sandwich immunoassay (Biosite) in 65 consecutive patients with congenital heart disease (age 4 days to 17.1 years, mean (S.D.) age 3.6 (4.7) years, median age 1.0 years) on the day before and after surgical therapy. BNP levels were compared to perioperative data and to healthy subjects. RESULTS: BNP increased significantly (p<0.001) after cardiac surgery from median 31 pg/ml (mean 189 pg/ml) to median 453 pg/ml (mean 607 pg/ml) and remained significantly elevated during the first week (p<0.001). After a first peak mean (S.D.) 1.3 (0.7) days after surgery, there was a significant decrease of plasma BNP followed by a second peak 5.1 (1.1) days after surgery. Postoperative BNP plasma concentration was correlated to BNP before surgery (r=0.58, p<0.001), to cardiopulmonary bypass duration (r=0.52, p<0.001) and to serum lactate concentration at the first day after surgery (r=0.49, p<0.001). CONCLUSIONS: In children with congenital heart defects plasma BNP increased immediately after cardiac surgery despite haemodynamic unloading. The correlation to cardiopulmonary bypass time and serum lactate concentration and the similarity between the pattern of BNP release after surgery and after myocardial ischaemia might be explained by a cytoprotective role for BNP after cardiac surgery. SN - 1874-1754 UR - https://www.unboundmedicine.com/medline/citation/16753233/Impact_of_cardiac_surgery_on_plasma_levels_of_B_type_natriuretic_peptide_in_children_with_congenital_heart_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0167-5273(06)00247-6 DB - PRIME DP - Unbound Medicine ER -