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No change between the serum brain-derived neurotrophic factor in female patients with anorexia nervosa before and after partial weight recovery.
Prog Neuropsychopharmacol Biol Psychiatry. 2006 Aug 30; 30(6):1117-21.PN

Abstract

BACKGROUND

Brain-derived neurotrophic factor (BDNF) is a member of the nerve growth factor family. Several lines of evidence indicate that BDNF plays a role in the pathophysiology of eating disorders (ED). We found that serum BDNF levels in patients with ED were significantly lower than in normal controls. The aim of this longitudinal study was to compare serum BDNF levels in patients with anorexia nervosa (AN) before (n=13, initial mean body mass index (BMI)=14.2 kg/m(2)+/-0.7) and after partial recovery (mean BMI=16.2 kg/m(2)+/-1.7, mean weight gain 5.0 kg+/-2.0), with age-matched normal control subjects (n=17, mean BMI=20.4 kg/m(2)+/-1.5).

METHODS

Eating related psychopathology and depressive symptoms were evaluated before and after partial weight recovery, using the Eating Disorder Inventory-2 (EDI-2) and the 17-item Hamilton Depression Rating Scale (HDRS). Serum BDNF levels were measured using a sandwich enzyme-linked immunosorbent assay.

RESULTS

Serum BDNF levels with the AN patients (14.5+/-4.4 ng/ml) were significantly (p<0.01) lower than in control subjects (22.1+/-8.9 ng/ml). There were no significant differences in serum BDNF levels between the patients with AN before (14.5+/-4.4 ng/ml) and after (17.2+/-6.9 ng/ml) partial weight recovery. In all subjects, there was a positive correlation (r=0.5, p<0.01) between the baseline BDNF levels and the EDI-2 scores (n=30). Furthermore, in all subjects there was a positive correlation (r=0.4, p<0.05) between the BDNF levels and the BMI.

CONCLUSIONS

Serum BDNF levels did not change after partial weight recovery in AN patients. Our results suggest that an alteration of the serum BDNF in AN patients is not due to changes in body weight. Thus, other possible mechanisms that could be related to low serum BDNF levels in AN patients should be evaluated.

Authors+Show Affiliations

Nakazato M
Department of Psychiatry, Chiba University Graduate School of Medicine, Inohana 1-8-1, Chiba City, Chiba, 260-8670, Japan. nakazato@faculty.chiba-u.jp
Hashimoto K
No affiliation info available
Yoshimura K
No affiliation info available
Hashimoto T
No affiliation info available
Shimizu E
No affiliation info available
Iyo M
No affiliation info available

MeSH

AdolescentAdultAnorexia NervosaBody Mass IndexBody WeightBrain-Derived Neurotrophic FactorDepressionFemaleHumansLongitudinal StudiesPsychiatric Status Rating ScalesWeight Gain

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16753247

Citation

Nakazato, Michiko, et al. "No Change Between the Serum Brain-derived Neurotrophic Factor in Female Patients With Anorexia Nervosa Before and After Partial Weight Recovery." Progress in Neuro-psychopharmacology & Biological Psychiatry, vol. 30, no. 6, 2006, pp. 1117-21.
Nakazato M, Hashimoto K, Yoshimura K, et al. No change between the serum brain-derived neurotrophic factor in female patients with anorexia nervosa before and after partial weight recovery. Prog Neuropsychopharmacol Biol Psychiatry. 2006;30(6):1117-21.
Nakazato, M., Hashimoto, K., Yoshimura, K., Hashimoto, T., Shimizu, E., & Iyo, M. (2006). No change between the serum brain-derived neurotrophic factor in female patients with anorexia nervosa before and after partial weight recovery. Progress in Neuro-psychopharmacology & Biological Psychiatry, 30(6), 1117-21.
Nakazato M, et al. No Change Between the Serum Brain-derived Neurotrophic Factor in Female Patients With Anorexia Nervosa Before and After Partial Weight Recovery. Prog Neuropsychopharmacol Biol Psychiatry. 2006 Aug 30;30(6):1117-21. PubMed PMID: 16753247.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - No change between the serum brain-derived neurotrophic factor in female patients with anorexia nervosa before and after partial weight recovery. AU - Nakazato,Michiko, AU - Hashimoto,Kenji, AU - Yoshimura,Kazuyuki, AU - Hashimoto,Tasuku, AU - Shimizu,Eiji, AU - Iyo,Masaomi, Y1 - 2006/06/06/ PY - 2006/6/7/pubmed PY - 2006/8/24/medline PY - 2006/6/7/entrez SP - 1117 EP - 21 JF - Progress in neuro-psychopharmacology & biological psychiatry JO - Prog Neuropsychopharmacol Biol Psychiatry VL - 30 IS - 6 N2 - BACKGROUND: Brain-derived neurotrophic factor (BDNF) is a member of the nerve growth factor family. Several lines of evidence indicate that BDNF plays a role in the pathophysiology of eating disorders (ED). We found that serum BDNF levels in patients with ED were significantly lower than in normal controls. The aim of this longitudinal study was to compare serum BDNF levels in patients with anorexia nervosa (AN) before (n=13, initial mean body mass index (BMI)=14.2 kg/m(2)+/-0.7) and after partial recovery (mean BMI=16.2 kg/m(2)+/-1.7, mean weight gain 5.0 kg+/-2.0), with age-matched normal control subjects (n=17, mean BMI=20.4 kg/m(2)+/-1.5). METHODS: Eating related psychopathology and depressive symptoms were evaluated before and after partial weight recovery, using the Eating Disorder Inventory-2 (EDI-2) and the 17-item Hamilton Depression Rating Scale (HDRS). Serum BDNF levels were measured using a sandwich enzyme-linked immunosorbent assay. RESULTS: Serum BDNF levels with the AN patients (14.5+/-4.4 ng/ml) were significantly (p<0.01) lower than in control subjects (22.1+/-8.9 ng/ml). There were no significant differences in serum BDNF levels between the patients with AN before (14.5+/-4.4 ng/ml) and after (17.2+/-6.9 ng/ml) partial weight recovery. In all subjects, there was a positive correlation (r=0.5, p<0.01) between the baseline BDNF levels and the EDI-2 scores (n=30). Furthermore, in all subjects there was a positive correlation (r=0.4, p<0.05) between the BDNF levels and the BMI. CONCLUSIONS: Serum BDNF levels did not change after partial weight recovery in AN patients. Our results suggest that an alteration of the serum BDNF in AN patients is not due to changes in body weight. Thus, other possible mechanisms that could be related to low serum BDNF levels in AN patients should be evaluated. SN - 0278-5846 UR - https://www.unboundmedicine.com/medline/citation/16753247/No_change_between_the_serum_brain_derived_neurotrophic_factor_in_female_patients_with_anorexia_nervosa_before_and_after_partial_weight_recovery_ DB - PRIME DP - Unbound Medicine ER -