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Lipid peroxidation, antioxidant status and survival in institutionalised elderly: a five-year longitudinal study.
Free Radic Res. 2006 Jun; 40(6):571-8.FR

Abstract

Oxidative stress has been related to ageing and risk of death. To determine whether oxidative status was associated with all-cause risk of death we carried out a prospective study in 154 non-smoking Spanish elderly without major illness. Baseline glutathione peroxidase (GPx) and superoxide dismutase (SOD) were analysed in plasma and erythrocytes. alpha-tocopherol, beta-carotene, lycopene and retinol were determined in serum samples and malondialdehyde (MDA), as a lipid peroxidation marker, in plasma. Mean survival time was 4.3 years. A total of 31 death cases (20.1%) occurred during the follow-up. Plasma-MDA predicted mortality independently of all other variables, while erythrocyte-SOD (e-SOD), beta-carotene and alpha-tocopherol were positively associated with survival. alpha-tocopherol and MDA were revealed as independent predictors in a joint survival model, being the group with low MDA and high alpha-tocopherol that with the lowest mortality. In conclusion, a higher risk of death was associated with increased lipid peroxidation and lower antioxidant defenses.

Authors+Show Affiliations

Departamento de Biología Funcional, Area de Fisiología. Facultad de Medicina, Universidad de Oviedo, Julián Clavería s/n, Oviedo 33006, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16753834

Citation

Huerta, José M., et al. "Lipid Peroxidation, Antioxidant Status and Survival in Institutionalised Elderly: a Five-year Longitudinal Study." Free Radical Research, vol. 40, no. 6, 2006, pp. 571-8.
Huerta JM, González S, Fernández S, et al. Lipid peroxidation, antioxidant status and survival in institutionalised elderly: a five-year longitudinal study. Free Radic Res. 2006;40(6):571-8.
Huerta, J. M., González, S., Fernández, S., Patterson, A. M., & Lasheras, C. (2006). Lipid peroxidation, antioxidant status and survival in institutionalised elderly: a five-year longitudinal study. Free Radical Research, 40(6), 571-8.
Huerta JM, et al. Lipid Peroxidation, Antioxidant Status and Survival in Institutionalised Elderly: a Five-year Longitudinal Study. Free Radic Res. 2006;40(6):571-8. PubMed PMID: 16753834.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lipid peroxidation, antioxidant status and survival in institutionalised elderly: a five-year longitudinal study. AU - Huerta,José M, AU - González,Sonia, AU - Fernández,Serafina, AU - Patterson,Angeles M, AU - Lasheras,Cristina, PY - 2006/6/7/pubmed PY - 2006/8/2/medline PY - 2006/6/7/entrez SP - 571 EP - 8 JF - Free radical research JO - Free Radic Res VL - 40 IS - 6 N2 - Oxidative stress has been related to ageing and risk of death. To determine whether oxidative status was associated with all-cause risk of death we carried out a prospective study in 154 non-smoking Spanish elderly without major illness. Baseline glutathione peroxidase (GPx) and superoxide dismutase (SOD) were analysed in plasma and erythrocytes. alpha-tocopherol, beta-carotene, lycopene and retinol were determined in serum samples and malondialdehyde (MDA), as a lipid peroxidation marker, in plasma. Mean survival time was 4.3 years. A total of 31 death cases (20.1%) occurred during the follow-up. Plasma-MDA predicted mortality independently of all other variables, while erythrocyte-SOD (e-SOD), beta-carotene and alpha-tocopherol were positively associated with survival. alpha-tocopherol and MDA were revealed as independent predictors in a joint survival model, being the group with low MDA and high alpha-tocopherol that with the lowest mortality. In conclusion, a higher risk of death was associated with increased lipid peroxidation and lower antioxidant defenses. SN - 1071-5762 UR - https://www.unboundmedicine.com/medline/citation/16753834/Lipid_peroxidation_antioxidant_status_and_survival_in_institutionalised_elderly:_a_five_year_longitudinal_study_ L2 - https://www.tandfonline.com/doi/full/10.1080/10715760600580470 DB - PRIME DP - Unbound Medicine ER -