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Involvement of NMDA receptors in morphine state-dependent learning in mice.
Int J Neurosci. 2006 Jun; 116(6):731-43.IJ

Abstract

In the present study, the effects of intracerebroventricular (i.c.v.) injection of NMDA receptor agonist and antagonist on impairment of memory formation and the state-dependent learning by morphine have been investigated in mice. Pretraining administration of morphine (5 mg/kg; s.c.) decreased the learning of one-trial passive avoidance task. Pretest administration of morphine (5 mg/kg) induced state-dependent learning acquired under pretraining morphine influence. Pretest administration of NMDA receptor agonist, L-glutamate (0.00001 and 0.0001 and 0.001 microg/mouse, i.c.v.) following pretraining saline treatment did not affect retention. Amnesia induced by pretraining morphine was significantly reversed by pretest administration of L-glutamate (0.0001 and 0.001 microg/mouse, i.c.v.). Pretest administration of noncompetitive NMDA receptor antagonist, MK-801 (0.5, 1, and 2 microg/mouse, i.c.v.) significantly impaired memory formation. Amnesia induced by pretraining morphine was increased by pretest administration of MK-801 (2 microg/mouse, i.c.v.). Pretest coadministration of L-glutamate (0.0001 and 0.001 microg/mouse, i.c.v.) or MK-801 (0.5, 1, and 2 microg/mouse, i.c.v.) with morphine (5 mg/kg, s.c.) increased and decreased morphine state-dependent learning, respectively. The results suggest that NMDA receptors are involved in morphine state-dependent learning in mice.

Authors+Show Affiliations

Department of Pharmacology, School of Medicine Tehran University of Medical Sciences, Tehran, Iran. zarinmr@ams.ac.irNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16753898

Citation

Zarrindast, Mohammad-Reza, et al. "Involvement of NMDA Receptors in Morphine State-dependent Learning in Mice." The International Journal of Neuroscience, vol. 116, no. 6, 2006, pp. 731-43.
Zarrindast MR, Jafari-Sabet M, Rezayat M, et al. Involvement of NMDA receptors in morphine state-dependent learning in mice. Int J Neurosci. 2006;116(6):731-43.
Zarrindast, M. R., Jafari-Sabet, M., Rezayat, M., Djahanguiri, B., & Rezayof, A. (2006). Involvement of NMDA receptors in morphine state-dependent learning in mice. The International Journal of Neuroscience, 116(6), 731-43.
Zarrindast MR, et al. Involvement of NMDA Receptors in Morphine State-dependent Learning in Mice. Int J Neurosci. 2006;116(6):731-43. PubMed PMID: 16753898.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Involvement of NMDA receptors in morphine state-dependent learning in mice. AU - Zarrindast,Mohammad-Reza, AU - Jafari-Sabet,Majid, AU - Rezayat,Mehdi, AU - Djahanguiri,Bijan, AU - Rezayof,Ameneh, PY - 2006/6/7/pubmed PY - 2006/7/27/medline PY - 2006/6/7/entrez SP - 731 EP - 43 JF - The International journal of neuroscience JO - Int J Neurosci VL - 116 IS - 6 N2 - In the present study, the effects of intracerebroventricular (i.c.v.) injection of NMDA receptor agonist and antagonist on impairment of memory formation and the state-dependent learning by morphine have been investigated in mice. Pretraining administration of morphine (5 mg/kg; s.c.) decreased the learning of one-trial passive avoidance task. Pretest administration of morphine (5 mg/kg) induced state-dependent learning acquired under pretraining morphine influence. Pretest administration of NMDA receptor agonist, L-glutamate (0.00001 and 0.0001 and 0.001 microg/mouse, i.c.v.) following pretraining saline treatment did not affect retention. Amnesia induced by pretraining morphine was significantly reversed by pretest administration of L-glutamate (0.0001 and 0.001 microg/mouse, i.c.v.). Pretest administration of noncompetitive NMDA receptor antagonist, MK-801 (0.5, 1, and 2 microg/mouse, i.c.v.) significantly impaired memory formation. Amnesia induced by pretraining morphine was increased by pretest administration of MK-801 (2 microg/mouse, i.c.v.). Pretest coadministration of L-glutamate (0.0001 and 0.001 microg/mouse, i.c.v.) or MK-801 (0.5, 1, and 2 microg/mouse, i.c.v.) with morphine (5 mg/kg, s.c.) increased and decreased morphine state-dependent learning, respectively. The results suggest that NMDA receptors are involved in morphine state-dependent learning in mice. SN - 0020-7454 UR - https://www.unboundmedicine.com/medline/citation/16753898/Involvement_of_NMDA_receptors_in_morphine_state_dependent_learning_in_mice_ L2 - https://www.tandfonline.com/doi/full/10.1080/00207450600675068 DB - PRIME DP - Unbound Medicine ER -