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Comparative neurophysiological study for the diagnosis of mild polyneuropathy in patients with diabetes mellitus and glucose intolerance.
Int J Neurosci. 2006 Jun; 116(6):745-59.IJ

Abstract

This article evaluates diagnostic sensitivity of minimal F-wave latency, sural/radial amplitude ratio (SRAR), dorsal sural/radial amplitude ratio (DSRAR), sympathetic skin response (SSR), and R-R interval variability (RRIV) for detecting early polyneuropathy in patients with glucose intolerance and diabetic patients. F-wave latencies were more prolonged in diabetic patients with normal and abnormal nerve conduction studies than control subjects (p < .001). SRAR was lower, SSR latency was more prolonged, and RRIV was lower in diabetic patients with abnormal nerve conduction studies than healty controls (p < .001). SSR latency was more prolonged and RRIV was lower in diabetic patients with normal nerve conduction studies than healty controls (p < .01, p < .05, respectively). DSRAR was lower in diabetic patients with normal and abnormal nerve conduction studies than control subjects (p < .001). DSRAR was also lower in patients with glucose intolerance than control subjects (p < .01). DSRAR was the most sensitive and specific test in either of diabetic patients with normal nerve conduction studies (sensitivity 66%, specificity 90%) and diabetic patients with abnormal nerve conduction studies (sensitivity 100%, specificity 90%). DSRAR is the most reliable method for detection of early nerve pathology. Patients with glucose intolerance might have subclinical neuropathy that can be demonstrated with DSRAR analysis.

Authors+Show Affiliations

Trakya University Medical Faculty, Neurology Department, Edirne, Turkey. nildaturgut@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16753899

Citation

Turgut, Nilda, et al. "Comparative Neurophysiological Study for the Diagnosis of Mild Polyneuropathy in Patients With Diabetes Mellitus and Glucose Intolerance." The International Journal of Neuroscience, vol. 116, no. 6, 2006, pp. 745-59.
Turgut N, Güldiken S, Balci K, et al. Comparative neurophysiological study for the diagnosis of mild polyneuropathy in patients with diabetes mellitus and glucose intolerance. Int J Neurosci. 2006;116(6):745-59.
Turgut, N., Güldiken, S., Balci, K., Tugrul, A., Berberoglu, U., & Altun, B. U. (2006). Comparative neurophysiological study for the diagnosis of mild polyneuropathy in patients with diabetes mellitus and glucose intolerance. The International Journal of Neuroscience, 116(6), 745-59.
Turgut N, et al. Comparative Neurophysiological Study for the Diagnosis of Mild Polyneuropathy in Patients With Diabetes Mellitus and Glucose Intolerance. Int J Neurosci. 2006;116(6):745-59. PubMed PMID: 16753899.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparative neurophysiological study for the diagnosis of mild polyneuropathy in patients with diabetes mellitus and glucose intolerance. AU - Turgut,Nilda, AU - Güldiken,Sibel, AU - Balci,Kemal, AU - Tugrul,Armagan, AU - Berberoglu,Ufuk, AU - Altun,Betül Ugur, PY - 2006/6/7/pubmed PY - 2006/7/27/medline PY - 2006/6/7/entrez SP - 745 EP - 59 JF - The International journal of neuroscience JO - Int J Neurosci VL - 116 IS - 6 N2 - This article evaluates diagnostic sensitivity of minimal F-wave latency, sural/radial amplitude ratio (SRAR), dorsal sural/radial amplitude ratio (DSRAR), sympathetic skin response (SSR), and R-R interval variability (RRIV) for detecting early polyneuropathy in patients with glucose intolerance and diabetic patients. F-wave latencies were more prolonged in diabetic patients with normal and abnormal nerve conduction studies than control subjects (p < .001). SRAR was lower, SSR latency was more prolonged, and RRIV was lower in diabetic patients with abnormal nerve conduction studies than healty controls (p < .001). SSR latency was more prolonged and RRIV was lower in diabetic patients with normal nerve conduction studies than healty controls (p < .01, p < .05, respectively). DSRAR was lower in diabetic patients with normal and abnormal nerve conduction studies than control subjects (p < .001). DSRAR was also lower in patients with glucose intolerance than control subjects (p < .01). DSRAR was the most sensitive and specific test in either of diabetic patients with normal nerve conduction studies (sensitivity 66%, specificity 90%) and diabetic patients with abnormal nerve conduction studies (sensitivity 100%, specificity 90%). DSRAR is the most reliable method for detection of early nerve pathology. Patients with glucose intolerance might have subclinical neuropathy that can be demonstrated with DSRAR analysis. SN - 0020-7454 UR - https://www.unboundmedicine.com/medline/citation/16753899/Comparative_neurophysiological_study_for_the_diagnosis_of_mild_polyneuropathy_in_patients_with_diabetes_mellitus_and_glucose_intolerance_ L2 - https://www.tandfonline.com/doi/full/10.1080/00207450600675340 DB - PRIME DP - Unbound Medicine ER -