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Differential effects of olmesartan and ramipril on inflammatory response after myocardial infarction in rats.
Blood Press. 2006; 15(2):116-28.BP

Abstract

This study compares the effect of two different strategies to inhibit the renin-angiotensin system in the setting of acute myocardial infarction (MI). Male Wistar rats were treated with placebo, the angiotensin-converting enzyme (ACE) inhibitor ramipril (1 mg/kg/day), or the AT1 receptor antagonist, olmesartan (1 mg/kg/day), both initiated 1 week before induction of MI and continued for 6 weeks after MI. The inflammatory reaction in the heart was investigated 7 days post-MI by determination of macrophage infiltration and the expression of tumor necrosis factor (TNF-alpha), interleukin (IL)-1beta and IL-6 at mRNA and protein levels. Six weeks post-MI, cardiac function was measured following chronic implantation of catheters in the LV and femoral artery, and cardiac morphology and coronary structure were investigated in picrosirius-red stained hearts. In placebo-treated rats, macrophage infiltration was accompanied by upregulation of IL-1beta and IL-6 mRNA in the peri-infarct zone. TNF-alpha and IL-1beta mRNA and protein were also upregulated in the non-infarcted myocardium. Whereas both treatment regimes significantly reduced IL-6 upregulation, olmesartan additionally reduced macrophage infiltration and IL-1beta expression. Six weeks post-MI, placebo-treated MI animals developed an impaired cardiac function with structural remodeling of the myocardium and coronaries. While olmesartan and ramipril both improved cardiac function and reduced infarct size and myocardial/coronary remodeling, olmesartan was more effective not only in increasing vascular perimeter, inner vascular diameter and septal thickness but also in lowering media thickness of coronary arteries, inner left ventricular diameter, left ventricular circumference and left ventricular end-diastolic pressure than ramipril. Thus, following MI the AT1 receptor blocker, olmesartan, attenuated cardiac inflammatory reactions and protected myocardial/coronary structure and function of the failing heart proving to be of similar, in some cases superior effectiveness in this respect than the ACE inhibitor, ramipril.

Authors+Show Affiliations

Center for Cardiovascular Research (CCR)/Institute of Pharmacology and Toxicology, Charité - University Medicine Berlin, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16754275

Citation

Sandmann, Steffen, et al. "Differential Effects of Olmesartan and Ramipril On Inflammatory Response After Myocardial Infarction in Rats." Blood Pressure, vol. 15, no. 2, 2006, pp. 116-28.
Sandmann S, Li J, Fritzenkötter C, et al. Differential effects of olmesartan and ramipril on inflammatory response after myocardial infarction in rats. Blood Press. 2006;15(2):116-28.
Sandmann, S., Li, J., Fritzenkötter, C., Spormann, J., Tiede, K., Fischer, J. W., & Unger, T. (2006). Differential effects of olmesartan and ramipril on inflammatory response after myocardial infarction in rats. Blood Pressure, 15(2), 116-28.
Sandmann S, et al. Differential Effects of Olmesartan and Ramipril On Inflammatory Response After Myocardial Infarction in Rats. Blood Press. 2006;15(2):116-28. PubMed PMID: 16754275.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differential effects of olmesartan and ramipril on inflammatory response after myocardial infarction in rats. AU - Sandmann,Steffen, AU - Li,Jun, AU - Fritzenkötter,Carolin, AU - Spormann,Johannes, AU - Tiede,Karen, AU - Fischer,Jens W, AU - Unger,Thomas, PY - 2006/6/7/pubmed PY - 2006/8/17/medline PY - 2006/6/7/entrez SP - 116 EP - 28 JF - Blood pressure JO - Blood Press VL - 15 IS - 2 N2 - This study compares the effect of two different strategies to inhibit the renin-angiotensin system in the setting of acute myocardial infarction (MI). Male Wistar rats were treated with placebo, the angiotensin-converting enzyme (ACE) inhibitor ramipril (1 mg/kg/day), or the AT1 receptor antagonist, olmesartan (1 mg/kg/day), both initiated 1 week before induction of MI and continued for 6 weeks after MI. The inflammatory reaction in the heart was investigated 7 days post-MI by determination of macrophage infiltration and the expression of tumor necrosis factor (TNF-alpha), interleukin (IL)-1beta and IL-6 at mRNA and protein levels. Six weeks post-MI, cardiac function was measured following chronic implantation of catheters in the LV and femoral artery, and cardiac morphology and coronary structure were investigated in picrosirius-red stained hearts. In placebo-treated rats, macrophage infiltration was accompanied by upregulation of IL-1beta and IL-6 mRNA in the peri-infarct zone. TNF-alpha and IL-1beta mRNA and protein were also upregulated in the non-infarcted myocardium. Whereas both treatment regimes significantly reduced IL-6 upregulation, olmesartan additionally reduced macrophage infiltration and IL-1beta expression. Six weeks post-MI, placebo-treated MI animals developed an impaired cardiac function with structural remodeling of the myocardium and coronaries. While olmesartan and ramipril both improved cardiac function and reduced infarct size and myocardial/coronary remodeling, olmesartan was more effective not only in increasing vascular perimeter, inner vascular diameter and septal thickness but also in lowering media thickness of coronary arteries, inner left ventricular diameter, left ventricular circumference and left ventricular end-diastolic pressure than ramipril. Thus, following MI the AT1 receptor blocker, olmesartan, attenuated cardiac inflammatory reactions and protected myocardial/coronary structure and function of the failing heart proving to be of similar, in some cases superior effectiveness in this respect than the ACE inhibitor, ramipril. SN - 0803-7051 UR - https://www.unboundmedicine.com/medline/citation/16754275/Differential_effects_of_olmesartan_and_ramipril_on_inflammatory_response_after_myocardial_infarction_in_rats_ L2 - https://www.tandfonline.com/doi/full/10.1080/08037050600586593 DB - PRIME DP - Unbound Medicine ER -