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Levels of matrix metalloproteinase-9 and its inhibitor in bronchoalveolar lavage cells of asthmatic children.
Fetal Pediatr Pathol. 2006 Jan-Feb; 25(1):1-7.FP

Abstract

Our objective was to investigate the role of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) and their cellular sources in childhood asthma. We used 12 controls and 16 asthmatic children. The levels of MMP-9 and TIMP-1 in bronchoalveolar lavage (BAL) cells of asthmatic children were measured immunocytochemically. The positive level index, defined as the percentage of positive-stained cells x average optical density, was used to assess the expressing levels of MMP-9 and TIMP-1. The percentages of eosinophils and mast cells in bronchoalveolar lavage fluid (BALF) of asthmatic children were increased. Levels of MMP-9 and TIMP-1 in BAL cell of asthmatic children were increased significantly at about 30- and 35-fold relative to the controls, respectively. These results suggest that both MMP-9 and TIMP-1 contribute to tissue remodeling. MMP-9, which mediates the degradation of extracellular matrix (ECM), is increased significantly in the early or acute stage and may play a role in ECM degeneration. Excessive TIMP-1 may be synthesized following MMP-9 production when the body tries to repair the damage, which results in excessive deposition of ECM component.

Authors+Show Affiliations

The Children's Hospital of Zhejiang University School of Medicine, Hangzhou, China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16754484

Citation

Tang, Lan Fang, et al. "Levels of Matrix Metalloproteinase-9 and Its Inhibitor in Bronchoalveolar Lavage Cells of Asthmatic Children." Fetal and Pediatric Pathology, vol. 25, no. 1, 2006, pp. 1-7.
Tang LF, Du LZ, Chen ZM, et al. Levels of matrix metalloproteinase-9 and its inhibitor in bronchoalveolar lavage cells of asthmatic children. Fetal Pediatr Pathol. 2006;25(1):1-7.
Tang, L. F., Du, L. Z., Chen, Z. M., & Zou, C. C. (2006). Levels of matrix metalloproteinase-9 and its inhibitor in bronchoalveolar lavage cells of asthmatic children. Fetal and Pediatric Pathology, 25(1), 1-7.
Tang LF, et al. Levels of Matrix Metalloproteinase-9 and Its Inhibitor in Bronchoalveolar Lavage Cells of Asthmatic Children. Fetal Pediatr Pathol. 2006 Jan-Feb;25(1):1-7. PubMed PMID: 16754484.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Levels of matrix metalloproteinase-9 and its inhibitor in bronchoalveolar lavage cells of asthmatic children. AU - Tang,Lan Fang, AU - Du,Li Zhong, AU - Chen,Zhi Min, AU - Zou,Chao Chun, PY - 2006/6/7/pubmed PY - 2006/7/26/medline PY - 2006/6/7/entrez SP - 1 EP - 7 JF - Fetal and pediatric pathology JO - Fetal Pediatr Pathol VL - 25 IS - 1 N2 - Our objective was to investigate the role of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) and their cellular sources in childhood asthma. We used 12 controls and 16 asthmatic children. The levels of MMP-9 and TIMP-1 in bronchoalveolar lavage (BAL) cells of asthmatic children were measured immunocytochemically. The positive level index, defined as the percentage of positive-stained cells x average optical density, was used to assess the expressing levels of MMP-9 and TIMP-1. The percentages of eosinophils and mast cells in bronchoalveolar lavage fluid (BALF) of asthmatic children were increased. Levels of MMP-9 and TIMP-1 in BAL cell of asthmatic children were increased significantly at about 30- and 35-fold relative to the controls, respectively. These results suggest that both MMP-9 and TIMP-1 contribute to tissue remodeling. MMP-9, which mediates the degradation of extracellular matrix (ECM), is increased significantly in the early or acute stage and may play a role in ECM degeneration. Excessive TIMP-1 may be synthesized following MMP-9 production when the body tries to repair the damage, which results in excessive deposition of ECM component. SN - 1551-3815 UR - https://www.unboundmedicine.com/medline/citation/16754484/Levels_of_matrix_metalloproteinase_9_and_its_inhibitor_in_bronchoalveolar_lavage_cells_of_asthmatic_children_ L2 - https://www.tandfonline.com/doi/full/10.1080/15227950600701396 DB - PRIME DP - Unbound Medicine ER -