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Childhood asthma and indoor aeroallergens and endotoxin in Palestine: a case-control study.
J Asthma. 2006 Apr; 43(3):241-7.JA

Abstract

This study was carried out to evaluate the relationship between wheezing or sensitization and concentrations of mites, cat and dog allergens, and bacterial endotoxin in Palestine. A nested case-control involved analysis of mattress and floor dust from a 110 children's houses with reported wheezing and without wheezing. We found no consistent associations between allergen levels and either wheeze or specific atopic sensitization. Furthermore, no clear associations between mattress endotoxin levels and wheeze or atopy were found. Endotoxin in floor dust was inversely associated with atopic sensitization and wheeze, statistically significant only for atopic wheeze. Finally, a nonsignificant inverse association was observed between living room endotoxin and atopy within the non-wheezing control group. In conclusion, although our study found mostly negative results, it does suggest that endotoxin on living room floors might protect against atopic wheeze. However, this finding should be interpreted with caution due the relatively small sample size of the study and requires further confirmation.

Authors+Show Affiliations

Laboratorium voor Longtoxicologie, Leuven, KU, Belgium.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16754529

Citation

El-Sharif, Nuha, et al. "Childhood Asthma and Indoor Aeroallergens and Endotoxin in Palestine: a Case-control Study." The Journal of Asthma : Official Journal of the Association for the Care of Asthma, vol. 43, no. 3, 2006, pp. 241-7.
El-Sharif N, Douwes J, Hoet P, et al. Childhood asthma and indoor aeroallergens and endotoxin in Palestine: a case-control study. J Asthma. 2006;43(3):241-7.
El-Sharif, N., Douwes, J., Hoet, P., & Nemery, B. (2006). Childhood asthma and indoor aeroallergens and endotoxin in Palestine: a case-control study. The Journal of Asthma : Official Journal of the Association for the Care of Asthma, 43(3), 241-7.
El-Sharif N, et al. Childhood Asthma and Indoor Aeroallergens and Endotoxin in Palestine: a Case-control Study. J Asthma. 2006;43(3):241-7. PubMed PMID: 16754529.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Childhood asthma and indoor aeroallergens and endotoxin in Palestine: a case-control study. AU - El-Sharif,Nuha, AU - Douwes,Jeroen, AU - Hoet,Peter, AU - Nemery,Benoit, PY - 2006/6/7/pubmed PY - 2006/6/28/medline PY - 2006/6/7/entrez SP - 241 EP - 7 JF - The Journal of asthma : official journal of the Association for the Care of Asthma JO - J Asthma VL - 43 IS - 3 N2 - This study was carried out to evaluate the relationship between wheezing or sensitization and concentrations of mites, cat and dog allergens, and bacterial endotoxin in Palestine. A nested case-control involved analysis of mattress and floor dust from a 110 children's houses with reported wheezing and without wheezing. We found no consistent associations between allergen levels and either wheeze or specific atopic sensitization. Furthermore, no clear associations between mattress endotoxin levels and wheeze or atopy were found. Endotoxin in floor dust was inversely associated with atopic sensitization and wheeze, statistically significant only for atopic wheeze. Finally, a nonsignificant inverse association was observed between living room endotoxin and atopy within the non-wheezing control group. In conclusion, although our study found mostly negative results, it does suggest that endotoxin on living room floors might protect against atopic wheeze. However, this finding should be interpreted with caution due the relatively small sample size of the study and requires further confirmation. SN - 0277-0903 UR - https://www.unboundmedicine.com/medline/citation/16754529/Childhood_asthma_and_indoor_aeroallergens_and_endotoxin_in_Palestine:_a_case_control_study_ L2 - https://www.tandfonline.com/doi/full/10.1080/02770900600567122 DB - PRIME DP - Unbound Medicine ER -