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Neuromelanin and iron in human locus coeruleus and substantia nigra during aging: consequences for neuronal vulnerability.
J Neural Transm (Vienna). 2006 Jun; 113(6):757-67.JN

Abstract

In this study a comparative analysis of iron molecules during aging was performed in locus coeruleus (LC) and substantia nigra (SN), known targets of Parkinson's Disease (PD) and related disorders. LC and SN neurons, especially the SN pars compacta, degenerate in PD and other forms of parkinsonism. Iron and its major molecular forms, such as ferritin and neuromelanin (NM), were measured in LC and SN of normal subjects at various ages. Iron levels were lower, H-ferritin/iron ratio was higher and the iron content in NM was lower in LC than in SN. Iron deposits were abundant in SN tissue, very scarse in LC tissue and completely absent in pigmented neurons of both SN and LC. In both regions H- and L-ferritins were present only in glia. This suggests that in LC neurons iron mobilization and toxicity is lower than that in SN and is efficiently buffered by NM. Ferritins accomplish the same buffering function in glial cells.

Authors+Show Affiliations

Institute of Biomedical Technologies - C.N.R., Segrate (Milano), Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16755380

Citation

Zucca, F A., et al. "Neuromelanin and Iron in Human Locus Coeruleus and Substantia Nigra During Aging: Consequences for Neuronal Vulnerability." Journal of Neural Transmission (Vienna, Austria : 1996), vol. 113, no. 6, 2006, pp. 757-67.
Zucca FA, Bellei C, Giannelli S, et al. Neuromelanin and iron in human locus coeruleus and substantia nigra during aging: consequences for neuronal vulnerability. J Neural Transm (Vienna). 2006;113(6):757-67.
Zucca, F. A., Bellei, C., Giannelli, S., Terreni, M. R., Gallorini, M., Rizzio, E., Pezzoli, G., Albertini, A., & Zecca, L. (2006). Neuromelanin and iron in human locus coeruleus and substantia nigra during aging: consequences for neuronal vulnerability. Journal of Neural Transmission (Vienna, Austria : 1996), 113(6), 757-67.
Zucca FA, et al. Neuromelanin and Iron in Human Locus Coeruleus and Substantia Nigra During Aging: Consequences for Neuronal Vulnerability. J Neural Transm (Vienna). 2006;113(6):757-67. PubMed PMID: 16755380.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neuromelanin and iron in human locus coeruleus and substantia nigra during aging: consequences for neuronal vulnerability. AU - Zucca,F A, AU - Bellei,C, AU - Giannelli,S, AU - Terreni,M R, AU - Gallorini,M, AU - Rizzio,E, AU - Pezzoli,G, AU - Albertini,A, AU - Zecca,L, Y1 - 2006/04/28/ PY - 2005/09/01/received PY - 2006/02/24/accepted PY - 2006/6/7/pubmed PY - 2007/5/9/medline PY - 2006/6/7/entrez SP - 757 EP - 67 JF - Journal of neural transmission (Vienna, Austria : 1996) JO - J Neural Transm (Vienna) VL - 113 IS - 6 N2 - In this study a comparative analysis of iron molecules during aging was performed in locus coeruleus (LC) and substantia nigra (SN), known targets of Parkinson's Disease (PD) and related disorders. LC and SN neurons, especially the SN pars compacta, degenerate in PD and other forms of parkinsonism. Iron and its major molecular forms, such as ferritin and neuromelanin (NM), were measured in LC and SN of normal subjects at various ages. Iron levels were lower, H-ferritin/iron ratio was higher and the iron content in NM was lower in LC than in SN. Iron deposits were abundant in SN tissue, very scarse in LC tissue and completely absent in pigmented neurons of both SN and LC. In both regions H- and L-ferritins were present only in glia. This suggests that in LC neurons iron mobilization and toxicity is lower than that in SN and is efficiently buffered by NM. Ferritins accomplish the same buffering function in glial cells. SN - 0300-9564 UR - https://www.unboundmedicine.com/medline/citation/16755380/Neuromelanin_and_iron_in_human_locus_coeruleus_and_substantia_nigra_during_aging:_consequences_for_neuronal_vulnerability_ L2 - https://doi.org/10.1007/s00702-006-0453-2 DB - PRIME DP - Unbound Medicine ER -