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Tonic and phasic processes in the acute effects of alcohol.
Exp Clin Psychopharmacol. 2006 May; 14(2):209-18.EC

Abstract

This article presents a novel method for measuring the acute effects of alcohol. One hundred twenty nonproblem drinkers aged 21-28 participated in 3 alcohol administration sessions that produced peak blood alcohol concentrations (BACs) near .09 g%. Subjective intoxication ratings were taken at multiple points across rising and falling BACs. Mathematical modeling techniques decomposed intoxication ratings into a tonic component sensitive to BAC level and a phasic component sensitive to BAC rate of change. This model provided a good fit to observed data. Tonic and phasic gain parameters showed high repeatability across sessions. The average phasic gain parameter was about 4 times larger than the average tonic gain parameter, indicating that subjective intoxication is usually more affected by BAC change than by BAC level. The associations of drinking practices with tonic and phasic gain parameters varied by gender and family history of alcoholism. Tonic-phasic modeling allows individual and group differences in the acute effects of alcohol to be studied as time-dynamic processes.

Authors+Show Affiliations

Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213, USA. martincs@upmc.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16756425

Citation

Martin, Christopher S., et al. "Tonic and Phasic Processes in the Acute Effects of Alcohol." Experimental and Clinical Psychopharmacology, vol. 14, no. 2, 2006, pp. 209-18.
Martin CS, Balaban CD, McBurney DH. Tonic and phasic processes in the acute effects of alcohol. Exp Clin Psychopharmacol. 2006;14(2):209-18.
Martin, C. S., Balaban, C. D., & McBurney, D. H. (2006). Tonic and phasic processes in the acute effects of alcohol. Experimental and Clinical Psychopharmacology, 14(2), 209-18.
Martin CS, Balaban CD, McBurney DH. Tonic and Phasic Processes in the Acute Effects of Alcohol. Exp Clin Psychopharmacol. 2006;14(2):209-18. PubMed PMID: 16756425.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tonic and phasic processes in the acute effects of alcohol. AU - Martin,Christopher S, AU - Balaban,Carey D, AU - McBurney,Donald H, PY - 2006/6/8/pubmed PY - 2006/10/27/medline PY - 2006/6/8/entrez SP - 209 EP - 18 JF - Experimental and clinical psychopharmacology JO - Exp Clin Psychopharmacol VL - 14 IS - 2 N2 - This article presents a novel method for measuring the acute effects of alcohol. One hundred twenty nonproblem drinkers aged 21-28 participated in 3 alcohol administration sessions that produced peak blood alcohol concentrations (BACs) near .09 g%. Subjective intoxication ratings were taken at multiple points across rising and falling BACs. Mathematical modeling techniques decomposed intoxication ratings into a tonic component sensitive to BAC level and a phasic component sensitive to BAC rate of change. This model provided a good fit to observed data. Tonic and phasic gain parameters showed high repeatability across sessions. The average phasic gain parameter was about 4 times larger than the average tonic gain parameter, indicating that subjective intoxication is usually more affected by BAC change than by BAC level. The associations of drinking practices with tonic and phasic gain parameters varied by gender and family history of alcoholism. Tonic-phasic modeling allows individual and group differences in the acute effects of alcohol to be studied as time-dynamic processes. SN - 1064-1297 UR - https://www.unboundmedicine.com/medline/citation/16756425/Tonic_and_phasic_processes_in_the_acute_effects_of_alcohol_ L2 - http://content.apa.org/journals/pha/14/2/209 DB - PRIME DP - Unbound Medicine ER -