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Prospective study of type 2 diabetes mellitus and risk of primary open-angle glaucoma in women.
Ophthalmology 2006; 113(7):1081-6O

Abstract

PURPOSE

To study the relation between type 2 diabetes mellitus (T2DM) and incident primary open-angle glaucoma (POAG) in women.

DESIGN

Prospective cohort analysis.

PARTICIPANTS

Seventy-six thousand three hundred eighteen women enrolled in the Nurses' Health Study (NHS).

METHODS

Women enrolled in the NHS from 1980 to 2000 were observed. Eligible participants were at least 40 years old, did not have POAG at baseline, and reported receiving eye examinations during follow-up. Potential confounders were assessed on biennial questionnaires, and a diagnosis of T2DM was confirmed on a validated supplemental questionnaire. During follow-up, 429 self-reported POAG cases confirmed by medical chart review were identified.

MAIN OUTCOME MEASURES

Multivariable rate ratios (RRs) of POAG and associated 95% confidence intervals (CIs) obtained from proportional hazards models.

RESULTS

After controlling for age, race, hypertension, body mass index, physical activity, alcohol intake, smoking, and family history of glaucoma, T2DM was positively associated with POAG (RR = 1.82 [95% CI = 1.23-2.70]). Nonetheless, the association did not strengthen with longer duration of diabetes: RR = 2.24 (95% CI = 1.31-3.84) for duration < 5 years versus RR = 1.54 (95% CI = 0.90-2.62) for duration > or = 5 years). In secondary analyses, to evaluate the potential for detection bias we controlled for additional factors such as the number of eye examinations, but T2DM remained positively associated with POAG.

CONCLUSION

Type 2 diabetes mellitus is associated with an increased risk of POAG in women.

Authors+Show Affiliations

Glaucoma Service, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA. Louis_Pasquale@meei.harvard.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16757028

Citation

Pasquale, Louis R., et al. "Prospective Study of Type 2 Diabetes Mellitus and Risk of Primary Open-angle Glaucoma in Women." Ophthalmology, vol. 113, no. 7, 2006, pp. 1081-6.
Pasquale LR, Kang JH, Manson JE, et al. Prospective study of type 2 diabetes mellitus and risk of primary open-angle glaucoma in women. Ophthalmology. 2006;113(7):1081-6.
Pasquale, L. R., Kang, J. H., Manson, J. E., Willett, W. C., Rosner, B. A., & Hankinson, S. E. (2006). Prospective study of type 2 diabetes mellitus and risk of primary open-angle glaucoma in women. Ophthalmology, 113(7), pp. 1081-6.
Pasquale LR, et al. Prospective Study of Type 2 Diabetes Mellitus and Risk of Primary Open-angle Glaucoma in Women. Ophthalmology. 2006;113(7):1081-6. PubMed PMID: 16757028.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prospective study of type 2 diabetes mellitus and risk of primary open-angle glaucoma in women. AU - Pasquale,Louis R, AU - Kang,Jae Hee, AU - Manson,JoAnn E, AU - Willett,Walter C, AU - Rosner,Bernard A, AU - Hankinson,Susan E, Y1 - 2006/06/06/ PY - 2005/10/08/received PY - 2006/01/09/revised PY - 2006/01/21/accepted PY - 2006/6/8/pubmed PY - 2006/7/21/medline PY - 2006/6/8/entrez SP - 1081 EP - 6 JF - Ophthalmology JO - Ophthalmology VL - 113 IS - 7 N2 - PURPOSE: To study the relation between type 2 diabetes mellitus (T2DM) and incident primary open-angle glaucoma (POAG) in women. DESIGN: Prospective cohort analysis. PARTICIPANTS: Seventy-six thousand three hundred eighteen women enrolled in the Nurses' Health Study (NHS). METHODS: Women enrolled in the NHS from 1980 to 2000 were observed. Eligible participants were at least 40 years old, did not have POAG at baseline, and reported receiving eye examinations during follow-up. Potential confounders were assessed on biennial questionnaires, and a diagnosis of T2DM was confirmed on a validated supplemental questionnaire. During follow-up, 429 self-reported POAG cases confirmed by medical chart review were identified. MAIN OUTCOME MEASURES: Multivariable rate ratios (RRs) of POAG and associated 95% confidence intervals (CIs) obtained from proportional hazards models. RESULTS: After controlling for age, race, hypertension, body mass index, physical activity, alcohol intake, smoking, and family history of glaucoma, T2DM was positively associated with POAG (RR = 1.82 [95% CI = 1.23-2.70]). Nonetheless, the association did not strengthen with longer duration of diabetes: RR = 2.24 (95% CI = 1.31-3.84) for duration < 5 years versus RR = 1.54 (95% CI = 0.90-2.62) for duration > or = 5 years). In secondary analyses, to evaluate the potential for detection bias we controlled for additional factors such as the number of eye examinations, but T2DM remained positively associated with POAG. CONCLUSION: Type 2 diabetes mellitus is associated with an increased risk of POAG in women. SN - 1549-4713 UR - https://www.unboundmedicine.com/medline/citation/16757028/Prospective_study_of_type_2_diabetes_mellitus_and_risk_of_primary_open_angle_glaucoma_in_women_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(06)00297-1 DB - PRIME DP - Unbound Medicine ER -