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Coronavirus HKU1 and other coronavirus infections in Hong Kong.
J Clin Microbiol. 2006 Jun; 44(6):2063-71.JC

Abstract

We have recently described the discovery of a novel coronavirus, coronavirus HKU1 (CoV-HKU1), associated with community-acquired pneumonia. However, the clinical spectrum of disease and the epidemiology of CoV-HKU1 infections in relation to infections with other respiratory viruses are unknown. In this 12-month prospective study, 4,181 nasopharyngeal aspirates from patients with acute respiratory tract infections were subjected to reverse transcription-PCRs specific for CoV-HKU1 and human coronaviruses NL63 (HCoV-NL63), OC43 (HCoV-OC43), and 229E (HCoV-229E). Coronaviruses were detected in 87 (2.1%) patients, with 13 (0.3%) positive for CoV-HKU1, 17 (0.4%) positive for HCoV-NL63, 53 (1.3%) positive for HCoV-OC43, and 4 (0.1%) positive for HCoV-229E. Of the 13 patients with CoV-HKU1 infections, 11 were children and 8 had underlying diseases. Similar to the case for other coronaviruses, upper respiratory infection was the most common presentation of CoV-HKU1 infections, although pneumonia, acute bronchiolitis, and asthmatic exacerbation also occurred. Despite a shorter duration of fever (mean, 1.7 days) and no difference in maximum temperature in children with CoV-HKU1 infections compared to patients with most other respiratory virus infections, a high incidence of febrile seizures (50%) was noted, which was significantly higher than those for HCoV-OC43 (14%), adenovirus (9%), human parainfluenza virus 1 (0%), and respiratory syncytial virus (8%) infections. CoV-HKU1 and HCoV-OC43 infections peaked in winter, although cases of the former also occurred in spring to early summer. This is in contrast to HCoV-NL63 infections, which mainly occurred in early summer and autumn but were absent in winter. Two genotypes of CoV-HKU1 cocirculated during the study period. Continuous studies over a longer period are warranted to ascertain the seasonal variation and relative importance of the different coronaviruses. Similar studies in other countries are required to better determine the epidemiology and genetic diversity of CoV-HKU1.

Links

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Authors+Show Affiliations

Lau SK
Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Hong Kong.
Woo PC
No affiliation info available
Yip CC
No affiliation info available
Tse H
No affiliation info available
Tsoi HW
No affiliation info available
Cheng VC
No affiliation info available
Lee P
No affiliation info available
Tang BS
No affiliation info available
Cheung CH
No affiliation info available
Lee RA
No affiliation info available
So LY
No affiliation info available
Lau YL
No affiliation info available
Chan KH
No affiliation info available
Yuen KY
No affiliation info available

MeSH

Acute DiseaseAged, 80 and overChildChild, PreschoolCoronavirusCoronavirus 229E, HumanCoronavirus InfectionsCoronavirus OC43, HumanFemaleHong KongHospitalizationHumansIncidenceInfantMaleMolecular Sequence DataNasopharynxPhylogenyRespiratory Tract InfectionsReverse Transcriptase Polymerase Chain ReactionSeizures, FebrileSequence Analysis, DNASeverity of Illness IndexViral Proteins

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16757599

Citation

Lau, Susanna K P., et al. "Coronavirus HKU1 and Other Coronavirus Infections in Hong Kong." Journal of Clinical Microbiology, vol. 44, no. 6, 2006, pp. 2063-71.
Lau SK, Woo PC, Yip CC, et al. Coronavirus HKU1 and other coronavirus infections in Hong Kong. J Clin Microbiol. 2006;44(6):2063-71.
Lau, S. K., Woo, P. C., Yip, C. C., Tse, H., Tsoi, H. W., Cheng, V. C., Lee, P., Tang, B. S., Cheung, C. H., Lee, R. A., So, L. Y., Lau, Y. L., Chan, K. H., & Yuen, K. Y. (2006). Coronavirus HKU1 and other coronavirus infections in Hong Kong. Journal of Clinical Microbiology, 44(6), 2063-71.
Lau SK, et al. Coronavirus HKU1 and Other Coronavirus Infections in Hong Kong. J Clin Microbiol. 2006;44(6):2063-71. PubMed PMID: 16757599.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Coronavirus HKU1 and other coronavirus infections in Hong Kong. AU - Lau,Susanna K P, AU - Woo,Patrick C Y, AU - Yip,Cyril C Y, AU - Tse,Herman, AU - Tsoi,Hoi-wah, AU - Cheng,Vincent C C, AU - Lee,Paul, AU - Tang,Bone S F, AU - Cheung,Chris H Y, AU - Lee,Rodney A, AU - So,Lok-yee, AU - Lau,Yu-lung, AU - Chan,Kwok-hung, AU - Yuen,Kwok-yung, PY - 2006/6/8/pubmed PY - 2006/8/4/medline PY - 2006/6/8/entrez SP - 2063 EP - 71 JF - Journal of clinical microbiology JO - J Clin Microbiol VL - 44 IS - 6 N2 - We have recently described the discovery of a novel coronavirus, coronavirus HKU1 (CoV-HKU1), associated with community-acquired pneumonia. However, the clinical spectrum of disease and the epidemiology of CoV-HKU1 infections in relation to infections with other respiratory viruses are unknown. In this 12-month prospective study, 4,181 nasopharyngeal aspirates from patients with acute respiratory tract infections were subjected to reverse transcription-PCRs specific for CoV-HKU1 and human coronaviruses NL63 (HCoV-NL63), OC43 (HCoV-OC43), and 229E (HCoV-229E). Coronaviruses were detected in 87 (2.1%) patients, with 13 (0.3%) positive for CoV-HKU1, 17 (0.4%) positive for HCoV-NL63, 53 (1.3%) positive for HCoV-OC43, and 4 (0.1%) positive for HCoV-229E. Of the 13 patients with CoV-HKU1 infections, 11 were children and 8 had underlying diseases. Similar to the case for other coronaviruses, upper respiratory infection was the most common presentation of CoV-HKU1 infections, although pneumonia, acute bronchiolitis, and asthmatic exacerbation also occurred. Despite a shorter duration of fever (mean, 1.7 days) and no difference in maximum temperature in children with CoV-HKU1 infections compared to patients with most other respiratory virus infections, a high incidence of febrile seizures (50%) was noted, which was significantly higher than those for HCoV-OC43 (14%), adenovirus (9%), human parainfluenza virus 1 (0%), and respiratory syncytial virus (8%) infections. CoV-HKU1 and HCoV-OC43 infections peaked in winter, although cases of the former also occurred in spring to early summer. This is in contrast to HCoV-NL63 infections, which mainly occurred in early summer and autumn but were absent in winter. Two genotypes of CoV-HKU1 cocirculated during the study period. Continuous studies over a longer period are warranted to ascertain the seasonal variation and relative importance of the different coronaviruses. Similar studies in other countries are required to better determine the epidemiology and genetic diversity of CoV-HKU1. SN - 0095-1137 UR - https://www.unboundmedicine.com/medline/citation/16757599/Coronavirus_HKU1_and_other_coronavirus_infections_in_Hong_Kong_ DB - PRIME DP - Unbound Medicine ER -