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[The significance of diet and associated factors in psoriasis].
Hautarzt 2006; 57(11):999-1004H

Abstract

Psoriasis is a T cell mediated inflammatory skin disease characterized by hyperproliferation and reduced differentiation of epidermal keratinocytes. In severe cases, the disease can result in an insufficient nutritional status which may even be promoted by nutrient-drug interactions. Both the general diet and single food components have been suggested to play a role in etiology and pathogenesis of psoriasis. Fasting periods, vegetarian diets, and diets rich in omega-3 polyunsaturated fatty acids from fish oil have all been associated with improvement in some studies. The most likely explanation is the reduced amounts of arachidonic acid and the increased eicosapentaenoic acid intake resulting in a modulated eicosanoid profile. However, only one of four controlled studies showed a benefit of omega-3 fatty acids compared to placebo. Some psoriasis patients are gluten-sensitive and may benefit from a gluten free diet. The active form of vitamin D exhibits anti-proliferative and immunoregulatory effects and has been shown to be useful in the treatment of psoriasis.

Authors+Show Affiliations

Abteilung Ernährungsphysiologie und Humanernährung, Institut für Lebensmittelwissenschaft, Zentrum Angewandte Chemie, Universität Hannover, Hannover, Germany. maike.wolters@lw.uni-hannover.de

Pub Type(s)

Comparative Study
English Abstract
Journal Article
Review

Language

ger

PubMed ID

16758223

Citation

Wolters, M. "[The Significance of Diet and Associated Factors in Psoriasis]." Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete, vol. 57, no. 11, 2006, pp. 999-1004.
Wolters M. [The significance of diet and associated factors in psoriasis]. Hautarzt. 2006;57(11):999-1004.
Wolters, M. (2006). [The significance of diet and associated factors in psoriasis]. Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete, 57(11), pp. 999-1004.
Wolters M. [The Significance of Diet and Associated Factors in Psoriasis]. Hautarzt. 2006;57(11):999-1004. PubMed PMID: 16758223.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The significance of diet and associated factors in psoriasis]. A1 - Wolters,M, PY - 2006/6/8/pubmed PY - 2007/4/28/medline PY - 2006/6/8/entrez SP - 999 EP - 1004 JF - Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete JO - Hautarzt VL - 57 IS - 11 N2 - Psoriasis is a T cell mediated inflammatory skin disease characterized by hyperproliferation and reduced differentiation of epidermal keratinocytes. In severe cases, the disease can result in an insufficient nutritional status which may even be promoted by nutrient-drug interactions. Both the general diet and single food components have been suggested to play a role in etiology and pathogenesis of psoriasis. Fasting periods, vegetarian diets, and diets rich in omega-3 polyunsaturated fatty acids from fish oil have all been associated with improvement in some studies. The most likely explanation is the reduced amounts of arachidonic acid and the increased eicosapentaenoic acid intake resulting in a modulated eicosanoid profile. However, only one of four controlled studies showed a benefit of omega-3 fatty acids compared to placebo. Some psoriasis patients are gluten-sensitive and may benefit from a gluten free diet. The active form of vitamin D exhibits anti-proliferative and immunoregulatory effects and has been shown to be useful in the treatment of psoriasis. SN - 0017-8470 UR - https://www.unboundmedicine.com/medline/citation/16758223/[The_significance_of_diet_and_associated_factors_in_psoriasis]_ L2 - https://dx.doi.org/10.1007/s00105-006-1164-1 DB - PRIME DP - Unbound Medicine ER -