Type your tag names separated by a space and hit enter

Role of US military research programs in the development of US Food and Drug Administration--approved antimalarial drugs.

Abstract

US military physicians and researchers helped identify the optimum treatment dose of the naturally occurring compound quinine and collaborated with the pharmaceutical industry in the development and eventual US Food and Drug Administration approval of the synthetic antimalarial drugs chloroquine, primaquine, chloroquine-primaquine, sulfadoxine-pyrimethamine, mefloquine, doxycycline, halofantrine, and atovaquone-proguanil. Because malaria parasites develop drug resistance, the US military must continue to support the creation and testing of new drugs to prevent and treat malaria until an effective malaria vaccine is developed. New antimalarial drugs also benefit civilians residing in and traveling to malarious areas.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Military Infectious Diseases Research Program, US Army Medical Research and Materiel Command, Fort Detrick, MD 21702-5012, USA. lynn.kitchen@amedd.army.mil

    ,

    Source

    MeSH

    Antimalarials
    Drug Approval
    Humans
    Malaria
    Military Medicine
    Military Personnel
    Research
    United States
    United States Food and Drug Administration

    Pub Type(s)

    Journal Article
    Research Support, U.S. Gov't, Non-P.H.S.
    Review

    Language

    eng

    PubMed ID

    16758420

    Citation

    Kitchen, Lynn W., et al. "Role of US Military Research Programs in the Development of US Food and Drug Administration--approved Antimalarial Drugs." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, vol. 43, no. 1, 2006, pp. 67-71.
    Kitchen LW, Vaughn DW, Skillman DR. Role of US military research programs in the development of US Food and Drug Administration--approved antimalarial drugs. Clin Infect Dis. 2006;43(1):67-71.
    Kitchen, L. W., Vaughn, D. W., & Skillman, D. R. (2006). Role of US military research programs in the development of US Food and Drug Administration--approved antimalarial drugs. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 43(1), pp. 67-71.
    Kitchen LW, Vaughn DW, Skillman DR. Role of US Military Research Programs in the Development of US Food and Drug Administration--approved Antimalarial Drugs. Clin Infect Dis. 2006 Jul 1;43(1):67-71. PubMed PMID: 16758420.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Role of US military research programs in the development of US Food and Drug Administration--approved antimalarial drugs. AU - Kitchen,Lynn W, AU - Vaughn,David W, AU - Skillman,Donald R, Y1 - 2006/05/24/ PY - 2005/12/27/received PY - 2006/03/01/accepted PY - 2006/6/8/pubmed PY - 2006/8/23/medline PY - 2006/6/8/entrez SP - 67 EP - 71 JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JO - Clin. Infect. Dis. VL - 43 IS - 1 N2 - US military physicians and researchers helped identify the optimum treatment dose of the naturally occurring compound quinine and collaborated with the pharmaceutical industry in the development and eventual US Food and Drug Administration approval of the synthetic antimalarial drugs chloroquine, primaquine, chloroquine-primaquine, sulfadoxine-pyrimethamine, mefloquine, doxycycline, halofantrine, and atovaquone-proguanil. Because malaria parasites develop drug resistance, the US military must continue to support the creation and testing of new drugs to prevent and treat malaria until an effective malaria vaccine is developed. New antimalarial drugs also benefit civilians residing in and traveling to malarious areas. SN - 1537-6591 UR - https://www.unboundmedicine.com/medline/citation/16758420/full_citation L2 - https://academic.oup.com/cid/article-lookup/doi/10.1086/504873 DB - PRIME DP - Unbound Medicine ER -