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Antidepressant-like and anxiolytic-like actions of the mGlu5 receptor antagonist MTEP, microinjected into lateral septal nuclei of male Wistar rats.
Prog Neuropsychopharmacol Biol Psychiatry. 2006 Aug 30; 30(6):1129-35.PN

Abstract

This study describes the effects of intra-lateral septal infusions of different doses of the mGluR5 antagonist MTEP in the DRL-72 s paradigm and the elevated plus-maze test in rats, two behavioral models known to be sensitive to antidepressant-like and anxiolytic-like drug effects, respectively. Intra-lateral septal infusions of MTEP induced a dose-dependent (5.0 microg/microl, P<0.05; 10.0 microg/microl, P<0.05) increase in reinforced lever presses and a cohesive rightward shift of the inter-response time distribution (5.0 microg/microl, P<0.05; 10.0 microg/microl, P<0.05). These effects are indicative of antidepressant-like actions of the compound. Desipramine, a prototypical antidepressant drug, induced (5.0 microg/microl; P<0.05) similar effects. In the elevated plus-maze test, intra-lateral septal infusions of MTEP (5.0 microg/microl, P<0.05; 10.0 microg/microl, P<0.05) increased the exploration of the open arms without affecting locomotion. This anxiolytic-like effect was similar to that observed with the infusion of the benzodiazepine midazolam (10.0 microg/microl; P<0.05) in the same brain area. It is concluded that intra-lateral septal infusions of the mGlu5 receptor antagonist MTEP produced antidepressant-like actions or anxiolytic-like effects in male rats.

Authors+Show Affiliations

Laboratorio de Psicobiología y Etología, Instituto de Investigaciones Psicológicas, Universidad Veracruzana, Jalapa, Veracruz, México. mimoli@todito.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16759778

Citation

Molina-Hernández, Miguel, et al. "Antidepressant-like and Anxiolytic-like Actions of the mGlu5 Receptor Antagonist MTEP, Microinjected Into Lateral Septal Nuclei of Male Wistar Rats." Progress in Neuro-psychopharmacology & Biological Psychiatry, vol. 30, no. 6, 2006, pp. 1129-35.
Molina-Hernández M, Tellez-Alcántara NP, Pérez-García J, et al. Antidepressant-like and anxiolytic-like actions of the mGlu5 receptor antagonist MTEP, microinjected into lateral septal nuclei of male Wistar rats. Prog Neuropsychopharmacol Biol Psychiatry. 2006;30(6):1129-35.
Molina-Hernández, M., Tellez-Alcántara, N. P., Pérez-García, J., Olivera-Lopez, J. I., & Jaramillo, M. T. (2006). Antidepressant-like and anxiolytic-like actions of the mGlu5 receptor antagonist MTEP, microinjected into lateral septal nuclei of male Wistar rats. Progress in Neuro-psychopharmacology & Biological Psychiatry, 30(6), 1129-35.
Molina-Hernández M, et al. Antidepressant-like and Anxiolytic-like Actions of the mGlu5 Receptor Antagonist MTEP, Microinjected Into Lateral Septal Nuclei of Male Wistar Rats. Prog Neuropsychopharmacol Biol Psychiatry. 2006 Aug 30;30(6):1129-35. PubMed PMID: 16759778.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antidepressant-like and anxiolytic-like actions of the mGlu5 receptor antagonist MTEP, microinjected into lateral septal nuclei of male Wistar rats. AU - Molina-Hernández,Miguel, AU - Tellez-Alcántara,Norma Patricia, AU - Pérez-García,Julián, AU - Olivera-Lopez,Jorge Iván, AU - Jaramillo,M Teresa, Y1 - 2006/06/08/ PY - 2006/01/26/received PY - 2006/04/11/revised PY - 2006/04/25/accepted PY - 2006/6/9/pubmed PY - 2006/8/24/medline PY - 2006/6/9/entrez SP - 1129 EP - 35 JF - Progress in neuro-psychopharmacology & biological psychiatry JO - Prog Neuropsychopharmacol Biol Psychiatry VL - 30 IS - 6 N2 - This study describes the effects of intra-lateral septal infusions of different doses of the mGluR5 antagonist MTEP in the DRL-72 s paradigm and the elevated plus-maze test in rats, two behavioral models known to be sensitive to antidepressant-like and anxiolytic-like drug effects, respectively. Intra-lateral septal infusions of MTEP induced a dose-dependent (5.0 microg/microl, P<0.05; 10.0 microg/microl, P<0.05) increase in reinforced lever presses and a cohesive rightward shift of the inter-response time distribution (5.0 microg/microl, P<0.05; 10.0 microg/microl, P<0.05). These effects are indicative of antidepressant-like actions of the compound. Desipramine, a prototypical antidepressant drug, induced (5.0 microg/microl; P<0.05) similar effects. In the elevated plus-maze test, intra-lateral septal infusions of MTEP (5.0 microg/microl, P<0.05; 10.0 microg/microl, P<0.05) increased the exploration of the open arms without affecting locomotion. This anxiolytic-like effect was similar to that observed with the infusion of the benzodiazepine midazolam (10.0 microg/microl; P<0.05) in the same brain area. It is concluded that intra-lateral septal infusions of the mGlu5 receptor antagonist MTEP produced antidepressant-like actions or anxiolytic-like effects in male rats. SN - 0278-5846 UR - https://www.unboundmedicine.com/medline/citation/16759778/Antidepressant_like_and_anxiolytic_like_actions_of_the_mGlu5_receptor_antagonist_MTEP_microinjected_into_lateral_septal_nuclei_of_male_Wistar_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-5846(06)00184-9 DB - PRIME DP - Unbound Medicine ER -