Tags

Type your tag names separated by a space and hit enter

Marked and independent prognostic significance of the CpG island methylator phenotype in neuroblastomas.
Cancer Lett. 2007 Mar 18; 247(2):253-8.CL

Abstract

The CpG island methylator phenotype (CIMP) was closely associated with poor overall survival (OS) in Japanese neuroblastoma (NBL) cases in our previous study. Here, in German NBL cases, CIMP(+) cases (n=95) showed markedly poorer OS (hazard ratio (HR)=9.5; P<0.0001) and disease-free survival (DFS) (HR=5.4; P<0.0001) than CIMP(-) cases (n=50). All the 23 cases with N-myc amplification had CIMP. Among the remaining cases without N-myc amplification, CIMP(+) cases (n=27) had a poorer OS (HR=4.5; P=0.02) and DFS (HR=5.2; P<0.0001) than CIMP(-) cases (n=95). In multivariate analysis, CIMP and N-myc amplification had an influence on OS and DFS independent of age and disease stage. CIMP had a stronger influence on DFS than N-myc amplification while N-myc had a stronger influence on OS.

Authors+Show Affiliations

Carcinogenesis Division, National Cancer Center Research Institute, University of Tokyo Graduate School of Medicine, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16759796

Citation

Abe, Masanobu, et al. "Marked and Independent Prognostic Significance of the CpG Island Methylator Phenotype in Neuroblastomas." Cancer Letters, vol. 247, no. 2, 2007, pp. 253-8.
Abe M, Westermann F, Nakagawara A, et al. Marked and independent prognostic significance of the CpG island methylator phenotype in neuroblastomas. Cancer Lett. 2007;247(2):253-8.
Abe, M., Westermann, F., Nakagawara, A., Takato, T., Schwab, M., & Ushijima, T. (2007). Marked and independent prognostic significance of the CpG island methylator phenotype in neuroblastomas. Cancer Letters, 247(2), 253-8.
Abe M, et al. Marked and Independent Prognostic Significance of the CpG Island Methylator Phenotype in Neuroblastomas. Cancer Lett. 2007 Mar 18;247(2):253-8. PubMed PMID: 16759796.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Marked and independent prognostic significance of the CpG island methylator phenotype in neuroblastomas. AU - Abe,Masanobu, AU - Westermann,Frank, AU - Nakagawara,Akira, AU - Takato,Tsuyoshi, AU - Schwab,Manfred, AU - Ushijima,Toshikazu, Y1 - 2006/06/06/ PY - 2006/04/28/received PY - 2006/05/02/accepted PY - 2006/6/9/pubmed PY - 2007/5/1/medline PY - 2006/6/9/entrez SP - 253 EP - 8 JF - Cancer letters JO - Cancer Lett VL - 247 IS - 2 N2 - The CpG island methylator phenotype (CIMP) was closely associated with poor overall survival (OS) in Japanese neuroblastoma (NBL) cases in our previous study. Here, in German NBL cases, CIMP(+) cases (n=95) showed markedly poorer OS (hazard ratio (HR)=9.5; P<0.0001) and disease-free survival (DFS) (HR=5.4; P<0.0001) than CIMP(-) cases (n=50). All the 23 cases with N-myc amplification had CIMP. Among the remaining cases without N-myc amplification, CIMP(+) cases (n=27) had a poorer OS (HR=4.5; P=0.02) and DFS (HR=5.2; P<0.0001) than CIMP(-) cases (n=95). In multivariate analysis, CIMP and N-myc amplification had an influence on OS and DFS independent of age and disease stage. CIMP had a stronger influence on DFS than N-myc amplification while N-myc had a stronger influence on OS. SN - 0304-3835 UR - https://www.unboundmedicine.com/medline/citation/16759796/Marked_and_independent_prognostic_significance_of_the_CpG_island_methylator_phenotype_in_neuroblastomas_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3835(06)00374-0 DB - PRIME DP - Unbound Medicine ER -