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Eosinophilic esophagitis.
Curr Opin Gastroenterol 2006; 22(4):429-32CO

Abstract

PURPOSE OF REVIEW

Eosinophilic esophagitis is a new disease commonly confused with gastroesophageal reflux disease. Because of different treatments, recognition of eosinophilic esophagitis is important.

RECENT FINDINGS

Recent work further characterizes the allergic response, demonstrating a population of eosinophils different from gut and blood that specifically homes to the esophagus in eosinophilic esophagitis. Further data suggest a multi-step allergy process starting with an atopic skin response that later primes the esophagus on further allergen exposure. Diagnosis of eosinophilic esophagitis is suggested by food impaction in a young adult with a personal and family history of allergy. Barium radiography may be useful for obvious signs of eosinophilic esophagitis including rings and strictures. Treatment is based on systemic or topical steroids or identification and elimination of food allergens sometimes with elemental diets. Recent data show the latter to be superior both for the short and long term but with the caveat of compliance being difficult.

SUMMARY

Eosinophilic esophagitis is an allergy-based disorder. It presents commonly in adults as long standing dysphagia, sometimes with food impaction. Radiography is useful but will miss subtle signs of eosinophilic esophagitis. Treatment options are limited to steroid formulations or avoidance of food allergens though compliance, particularly with elemental formulas, remains problematic.

Authors+Show Affiliations

Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA. david.katzka@uphs.upenn.edu

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16760762

Citation

Katzka, David A.. "Eosinophilic Esophagitis." Current Opinion in Gastroenterology, vol. 22, no. 4, 2006, pp. 429-32.
Katzka DA. Eosinophilic esophagitis. Curr Opin Gastroenterol. 2006;22(4):429-32.
Katzka, D. A. (2006). Eosinophilic esophagitis. Current Opinion in Gastroenterology, 22(4), pp. 429-32.
Katzka DA. Eosinophilic Esophagitis. Curr Opin Gastroenterol. 2006;22(4):429-32. PubMed PMID: 16760762.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Eosinophilic esophagitis. A1 - Katzka,David A, PY - 2006/6/9/pubmed PY - 2006/11/11/medline PY - 2006/6/9/entrez SP - 429 EP - 32 JF - Current opinion in gastroenterology JO - Curr. Opin. Gastroenterol. VL - 22 IS - 4 N2 - PURPOSE OF REVIEW: Eosinophilic esophagitis is a new disease commonly confused with gastroesophageal reflux disease. Because of different treatments, recognition of eosinophilic esophagitis is important. RECENT FINDINGS: Recent work further characterizes the allergic response, demonstrating a population of eosinophils different from gut and blood that specifically homes to the esophagus in eosinophilic esophagitis. Further data suggest a multi-step allergy process starting with an atopic skin response that later primes the esophagus on further allergen exposure. Diagnosis of eosinophilic esophagitis is suggested by food impaction in a young adult with a personal and family history of allergy. Barium radiography may be useful for obvious signs of eosinophilic esophagitis including rings and strictures. Treatment is based on systemic or topical steroids or identification and elimination of food allergens sometimes with elemental diets. Recent data show the latter to be superior both for the short and long term but with the caveat of compliance being difficult. SUMMARY: Eosinophilic esophagitis is an allergy-based disorder. It presents commonly in adults as long standing dysphagia, sometimes with food impaction. Radiography is useful but will miss subtle signs of eosinophilic esophagitis. Treatment options are limited to steroid formulations or avoidance of food allergens though compliance, particularly with elemental formulas, remains problematic. SN - 0267-1379 UR - https://www.unboundmedicine.com/medline/citation/16760762/Eosinophilic_esophagitis_ L2 - http://Insights.ovid.com/pubmed?pmid=16760762 DB - PRIME DP - Unbound Medicine ER -