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Risk factors for oral hairy leukoplakia in HIV-infected adults of Brazil.
J Oral Pathol Med. 2006 Jul; 35(6):321-6.JO

Abstract

BACKGROUND

Oral hairy leukoplakia (OHL) may be an indicator of the progression of Human Immunodeficiency Virus (HIV)-induced immuno-depression, and the evaluation of risk factors leading to OHL is important in the management of these HIV-infected patients. However, there are few studies that analyze risk factors leading to OHL in the Brazilian population. The aim of this case-control study is to present data about prevalence rates and risk factors leading to OHL in a sample of HIV-infected adults in Brazil.

METHODS

This case-control study included 111 HIV-infected patients treated at a clinic for sexually transmitted diseases and HIV. In the initial examinations with dentists, variables were collected from all patients. Diagnosis of OHL was performed in accordance with the International Classification System and cytological features. The Fisher and the chi-squared tests were used for statistical analysis. The proportional prevalence and odds ratio were estimated.

RESULTS

Outcome presented a positive, statistically significant association among the presence of OHL and viral load of 3000 copies/mul or greater (P = 0.0001; odds ratio (OR) = 5.8), presence of oral candidiasis (P = 0.0000; OR = 11.1), previous use of fluconazole (P = 0.0000; OR = 24.6), and use of systemic acyclovir (P = 0.032; OR = 4.3). Antiretroviral medication presented a negative, statistically significant association with the presence of OHL (P = 0.002; OR = 8.4).

CONCLUSIONS

Prevalence of OHL was 28.8%. Viral load, oral candidiasis, previous use of fluconazole, and systemic acyclovir were determined to be risk factors for OHL. Antiretroviral medication proved to be protective against the development of OHL.

Authors+Show Affiliations

Moura MD
Oral Pathology, Medicine and Surgery Department, Dentistry School, Federal University of Minas Gerais, Av. Antônio Carlos 6627, Pampulha, 31270-901 Belo Horizonte, MG, Brazil.
Grossmann Sde M
No affiliation info available
Fonseca LM
No affiliation info available
Senna MI
No affiliation info available
Mesquita RA
No affiliation info available

MeSH

AdultAnalysis of VarianceAntiretroviral Therapy, Highly ActiveBrazilCD4 Lymphocyte CountChi-Square DistributionFemaleHIV InfectionsHumansLeukoplakia, HairyMaleMiddle AgedOdds RatioPrevalenceRisk FactorsViral Load

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16762011

Citation

Moura, Mariela Dutra Gontijo, et al. "Risk Factors for Oral Hairy Leukoplakia in HIV-infected Adults of Brazil." Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, vol. 35, no. 6, 2006, pp. 321-6.
Moura MD, Grossmann Sde M, Fonseca LM, et al. Risk factors for oral hairy leukoplakia in HIV-infected adults of Brazil. J Oral Pathol Med. 2006;35(6):321-6.
Moura, M. D., Grossmann, S. d. e. . M., Fonseca, L. M., Senna, M. I., & Mesquita, R. A. (2006). Risk factors for oral hairy leukoplakia in HIV-infected adults of Brazil. Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 35(6), 321-6.
Moura MD, et al. Risk Factors for Oral Hairy Leukoplakia in HIV-infected Adults of Brazil. J Oral Pathol Med. 2006;35(6):321-6. PubMed PMID: 16762011.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk factors for oral hairy leukoplakia in HIV-infected adults of Brazil. AU - Moura,Mariela Dutra Gontijo, AU - Grossmann,Soraya de Mattos Camargo, AU - Fonseca,Linaena Méricy da Silva, AU - Senna,Maria Inês Barreiros, AU - Mesquita,Ricardo Alves, PY - 2006/6/10/pubmed PY - 2006/8/30/medline PY - 2006/6/10/entrez SP - 321 EP - 6 JF - Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology JO - J Oral Pathol Med VL - 35 IS - 6 N2 - BACKGROUND: Oral hairy leukoplakia (OHL) may be an indicator of the progression of Human Immunodeficiency Virus (HIV)-induced immuno-depression, and the evaluation of risk factors leading to OHL is important in the management of these HIV-infected patients. However, there are few studies that analyze risk factors leading to OHL in the Brazilian population. The aim of this case-control study is to present data about prevalence rates and risk factors leading to OHL in a sample of HIV-infected adults in Brazil. METHODS: This case-control study included 111 HIV-infected patients treated at a clinic for sexually transmitted diseases and HIV. In the initial examinations with dentists, variables were collected from all patients. Diagnosis of OHL was performed in accordance with the International Classification System and cytological features. The Fisher and the chi-squared tests were used for statistical analysis. The proportional prevalence and odds ratio were estimated. RESULTS: Outcome presented a positive, statistically significant association among the presence of OHL and viral load of 3000 copies/mul or greater (P = 0.0001; odds ratio (OR) = 5.8), presence of oral candidiasis (P = 0.0000; OR = 11.1), previous use of fluconazole (P = 0.0000; OR = 24.6), and use of systemic acyclovir (P = 0.032; OR = 4.3). Antiretroviral medication presented a negative, statistically significant association with the presence of OHL (P = 0.002; OR = 8.4). CONCLUSIONS: Prevalence of OHL was 28.8%. Viral load, oral candidiasis, previous use of fluconazole, and systemic acyclovir were determined to be risk factors for OHL. Antiretroviral medication proved to be protective against the development of OHL. SN - 0904-2512 UR - https://www.unboundmedicine.com/medline/citation/16762011/Risk_factors_for_oral_hairy_leukoplakia_in_HIV_infected_adults_of_Brazil_ DB - PRIME DP - Unbound Medicine ER -