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[Study on the association between estrogen receptor alpha gene polymorphism and intrahepatic cholestasis of pregnancy].
Zhonghua Fu Chan Ke Za Zhi. 2006 May; 41(5):307-10.ZF

Abstract

OBJECTIVE

To investigate the relationship between estrogen receptor alpha (ERalpha) gene polymorphism and intrahepatic cholestasis of pregnancy (ICP).

METHODS

The Xba I and Pvu II polymorphisms in intron 1 of ER alpha gene were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method in 100 pregnant women with ICP (ICP group) and 100 normal pregnant women (control group).

RESULTS

(1) The frequencies of XX, Xx and xx genotypes of Xba I polymorphism were 6%, 33% and 61% respectively in control group, and were 2%, 33% and 65% respectively in ICP group. There was no significant difference in the distribution of Xba I genotypes between the two groups (P > 0.05). The frequencies of the two alleles X and x were 23% and 78% in control group, and were 19% and 82% in ICP group, respectively. There was also no significant difference in the frequency of Xba I alleles between the two groups (P > 0.05). (2) The frequencies of PP, Pp and pp genotypes of Pvu II polymorphism were 18%, 42% and 40% respectively in control group, and were 12%, 53% and 35% respectively in ICP group. There was no significant difference in the distribution of Pvu II genotypes between the two groups (P > 0.05). The frequencies of the two alleles P and p were 39% and 61% in control group, and were 39% and 62% in ICP group, respectively. There was also no significant difference in the frequency of Pvu II alleles between the two groups (P > 0.05). (3) There was also no significant difference in the distribution of Xba I and Pvu II combinative genotype between the two groups (P > 0.05).

CONCLUSION

The ERalpha gene polymorphism is not associated with the risk of ICP.

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Authors+Show Affiliations

Zhang L
Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, Chengdu 610041, China.
Liu SY
No affiliation info available
Shi QY
No affiliation info available
Chen Q
No affiliation info available
Zou H
No affiliation info available
Xing AY
No affiliation info available

MeSH

AdultAllelesCholestasis, IntrahepaticEstrogen Receptor alphaFemaleGene FrequencyGenotypeHumansPolymerase Chain ReactionPolymorphism, GeneticPolymorphism, Restriction Fragment LengthPregnancyPregnancy ComplicationsRisk Factors

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

16762184

Citation

Zhang, Li, et al. "[Study On the Association Between Estrogen Receptor Alpha Gene Polymorphism and Intrahepatic Cholestasis of Pregnancy]." Zhonghua Fu Chan Ke Za Zhi, vol. 41, no. 5, 2006, pp. 307-10.
Zhang L, Liu SY, Shi QY, et al. [Study on the association between estrogen receptor alpha gene polymorphism and intrahepatic cholestasis of pregnancy]. Zhonghua Fu Chan Ke Za Zhi. 2006;41(5):307-10.
Zhang, L., Liu, S. Y., Shi, Q. Y., Chen, Q., Zou, H., & Xing, A. Y. (2006). [Study on the association between estrogen receptor alpha gene polymorphism and intrahepatic cholestasis of pregnancy]. Zhonghua Fu Chan Ke Za Zhi, 41(5), 307-10.
Zhang L, et al. [Study On the Association Between Estrogen Receptor Alpha Gene Polymorphism and Intrahepatic Cholestasis of Pregnancy]. Zhonghua Fu Chan Ke Za Zhi. 2006;41(5):307-10. PubMed PMID: 16762184.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Study on the association between estrogen receptor alpha gene polymorphism and intrahepatic cholestasis of pregnancy]. AU - Zhang,Li, AU - Liu,Shu-yun, AU - Shi,Qing-yun, AU - Chen,Qiang, AU - Zou,Hai, AU - Xing,Ai-yun, PY - 2006/6/10/pubmed PY - 2008/2/15/medline PY - 2006/6/10/entrez SP - 307 EP - 10 JF - Zhonghua fu chan ke za zhi JO - Zhonghua Fu Chan Ke Za Zhi VL - 41 IS - 5 N2 - OBJECTIVE: To investigate the relationship between estrogen receptor alpha (ERalpha) gene polymorphism and intrahepatic cholestasis of pregnancy (ICP). METHODS: The Xba I and Pvu II polymorphisms in intron 1 of ER alpha gene were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method in 100 pregnant women with ICP (ICP group) and 100 normal pregnant women (control group). RESULTS: (1) The frequencies of XX, Xx and xx genotypes of Xba I polymorphism were 6%, 33% and 61% respectively in control group, and were 2%, 33% and 65% respectively in ICP group. There was no significant difference in the distribution of Xba I genotypes between the two groups (P > 0.05). The frequencies of the two alleles X and x were 23% and 78% in control group, and were 19% and 82% in ICP group, respectively. There was also no significant difference in the frequency of Xba I alleles between the two groups (P > 0.05). (2) The frequencies of PP, Pp and pp genotypes of Pvu II polymorphism were 18%, 42% and 40% respectively in control group, and were 12%, 53% and 35% respectively in ICP group. There was no significant difference in the distribution of Pvu II genotypes between the two groups (P > 0.05). The frequencies of the two alleles P and p were 39% and 61% in control group, and were 39% and 62% in ICP group, respectively. There was also no significant difference in the frequency of Pvu II alleles between the two groups (P > 0.05). (3) There was also no significant difference in the distribution of Xba I and Pvu II combinative genotype between the two groups (P > 0.05). CONCLUSION: The ERalpha gene polymorphism is not associated with the risk of ICP. SN - 0529-567X UR - https://www.unboundmedicine.com/medline/citation/16762184/[Study_on_the_association_between_estrogen_receptor_alpha_gene_polymorphism_and_intrahepatic_cholestasis_of_pregnancy]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&issn=0529-567X&year=2006&vol=41&issue=5&fpage=307 DB - PRIME DP - Unbound Medicine ER -