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Is there an association between GNbeta3-C825T genotype and lower functional gastrointestinal disorders?
Gastroenterology. 2006 Jun; 130(7):1985-94.G

Abstract

BACKGROUND & AIMS

GNbeta3 influences G-protein translation of a majority of ligand-receptor activations. It has been reported that functional dyspepsia (FD) is associated with homozygous genotypes of the C825T polymorphism in the GNbeta3 gene. It is unknown whether the GNbeta3 genotype is associated with lower functional gastrointestinal disorders (FGID). We aimed to compare the prevalence of the different GNbeta3-C825T genotypes in patients with lower FGID and healthy controls and to test the associations of these genetic variations with subgroups of irritable bowel syndrome (IBS), functional abdominal pain (FAP), lower FGID-FD overlap, and high somatic symptom scores.

METHODS

GNbeta3-C825T polymorphism was analyzed in DNA from blood samples of 233 patients with lower FGID and 152 healthy controls. A validated bowel questionnaire characterized the FGID phenotype: 82 with IBS constipation, 94 with IBS diarrhea, 38 with IBS alternating bowel function, and 19 with FAP. There were 159 patients with lower FGID and overlap FD using Rome II criteria. Regression analyses assessed associations of the GNbeta3 genotypes with lower FGID as a group, and subgroups of FGID and somatic symptom scores.

RESULTS

GNbeta3-C825T genotype distributions were similar between healthy controls (50.7% CC, 40.8% TC) and patients with lower FGID (8.6% TT, 51.5% CC, 40.8% TC, and 7.7% TT). There were no significant associations of GNbeta3-C825T polymorphism with lower FGID overall or with the separate symptom subgroups including IBS, FAP, lower FGID-FD overlap, or high somatic symptom scores.

CONCLUSIONS

In contrast to the reported association with FD, GNbeta3-C825T polymorphism is not associated significantly with lower FGID, with different IBS or FAP phenotypes, or lower FGID-FD overlap.

Authors+Show Affiliations

Clinical Enteric Neuroscience Translational and Epidemiological Research (C.E.N.T.E.R.) Program, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16762621

Citation

Andresen, Viola, et al. "Is There an Association Between GNbeta3-C825T Genotype and Lower Functional Gastrointestinal Disorders?" Gastroenterology, vol. 130, no. 7, 2006, pp. 1985-94.
Andresen V, Camilleri M, Kim HJ, et al. Is there an association between GNbeta3-C825T genotype and lower functional gastrointestinal disorders? Gastroenterology. 2006;130(7):1985-94.
Andresen, V., Camilleri, M., Kim, H. J., Stephens, D. A., Carlson, P. J., Talley, N. J., Saito, Y. A., Urrutia, R., & Zinsmeister, A. R. (2006). Is there an association between GNbeta3-C825T genotype and lower functional gastrointestinal disorders? Gastroenterology, 130(7), 1985-94.
Andresen V, et al. Is There an Association Between GNbeta3-C825T Genotype and Lower Functional Gastrointestinal Disorders. Gastroenterology. 2006;130(7):1985-94. PubMed PMID: 16762621.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Is there an association between GNbeta3-C825T genotype and lower functional gastrointestinal disorders? AU - Andresen,Viola, AU - Camilleri,Michael, AU - Kim,H Jae, AU - Stephens,Debra A, AU - Carlson,Paula J, AU - Talley,Nicholas J, AU - Saito,Yuri A, AU - Urrutia,Raul, AU - Zinsmeister,Alan R, PY - 2005/10/14/received PY - 2006/03/09/accepted PY - 2006/6/10/pubmed PY - 2006/7/19/medline PY - 2006/6/10/entrez SP - 1985 EP - 94 JF - Gastroenterology JO - Gastroenterology VL - 130 IS - 7 N2 - BACKGROUND & AIMS: GNbeta3 influences G-protein translation of a majority of ligand-receptor activations. It has been reported that functional dyspepsia (FD) is associated with homozygous genotypes of the C825T polymorphism in the GNbeta3 gene. It is unknown whether the GNbeta3 genotype is associated with lower functional gastrointestinal disorders (FGID). We aimed to compare the prevalence of the different GNbeta3-C825T genotypes in patients with lower FGID and healthy controls and to test the associations of these genetic variations with subgroups of irritable bowel syndrome (IBS), functional abdominal pain (FAP), lower FGID-FD overlap, and high somatic symptom scores. METHODS: GNbeta3-C825T polymorphism was analyzed in DNA from blood samples of 233 patients with lower FGID and 152 healthy controls. A validated bowel questionnaire characterized the FGID phenotype: 82 with IBS constipation, 94 with IBS diarrhea, 38 with IBS alternating bowel function, and 19 with FAP. There were 159 patients with lower FGID and overlap FD using Rome II criteria. Regression analyses assessed associations of the GNbeta3 genotypes with lower FGID as a group, and subgroups of FGID and somatic symptom scores. RESULTS: GNbeta3-C825T genotype distributions were similar between healthy controls (50.7% CC, 40.8% TC) and patients with lower FGID (8.6% TT, 51.5% CC, 40.8% TC, and 7.7% TT). There were no significant associations of GNbeta3-C825T polymorphism with lower FGID overall or with the separate symptom subgroups including IBS, FAP, lower FGID-FD overlap, or high somatic symptom scores. CONCLUSIONS: In contrast to the reported association with FD, GNbeta3-C825T polymorphism is not associated significantly with lower FGID, with different IBS or FAP phenotypes, or lower FGID-FD overlap. SN - 0016-5085 UR - https://www.unboundmedicine.com/medline/citation/16762621/Is_there_an_association_between_GNbeta3_C825T_genotype_and_lower_functional_gastrointestinal_disorders L2 - https://linkinghub.elsevier.com/retrieve/pii/S0016-5085(06)00566-X DB - PRIME DP - Unbound Medicine ER -