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Low maternal vitamin E intake during pregnancy is associated with asthma in 5-year-old children.
Am J Respir Crit Care Med. 2006 Sep 01; 174(5):499-507.AJ

Abstract

RATIONALE

We have previously reported an association between reduced maternal vitamin E intake during pregnancy and wheezing in 2-yr-old children.

OBJECTIVES

To assess whether maternal nutrient intake during pregnancy is associated with asthma-related outcomes in children aged 5 yr.

METHODS

A longitudinal cohort study of 1,861 children born to women recruited during pregnancy and followed up at 5 yr.

MEASUREMENTS

Maternal nutrient status was assessed by a food frequency questionnaire and plasma levels. Respiratory and food frequency questionnaires were completed at 5 yr and children were invited for measurement of spirometry and skin-prick testing.

MAIN RESULTS

Symptom and food frequency questionnaire data were available for 1,253 and 1,120 children, respectively; 700 children were skin prick tested, and FEV(1) was measured in 478 and exhaled nitric oxide in 167 children. In 5-yr-old children, maternal vitamin E intake during pregnancy was negatively associated with wheeze in previous year (odds ratio per intake quintile, 0.82; 95% confidence interval, 0.71-0.95), asthma ever (0.84, 0.72-0.98), asthma and wheeze in previous year (0.79, 0.65-0.95), and persistent wheezing (0.77, 0.63-0.93). Maternal plasma alpha-tocopherol during pregnancy was positively associated with post-bronchodilator FEV(1) at 5 yr, with a 7-ml (95% confidence interval, 0-14; p = 0.04) increase in FEV(1) per microg/ml alpha-tocopherol. Maternal zinc intake during pregnancy was negatively associated with asthma ever (0.83, 0.71-0.78) and active asthma (0.72, 0.59-0.89). There were no associations between children's nutrient intake and respiratory outcomes.

CONCLUSION

Maternal intake of foods containing vitamin E and zinc during pregnancy is associated with differences in the risks of developing childhood wheeze and asthma.

Authors+Show Affiliations

Department of Environmental and Occupational Medicine, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZB, UK. g.devereux@abdn.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16763215

Citation

Devereux, Graham, et al. "Low Maternal Vitamin E Intake During Pregnancy Is Associated With Asthma in 5-year-old Children." American Journal of Respiratory and Critical Care Medicine, vol. 174, no. 5, 2006, pp. 499-507.
Devereux G, Turner SW, Craig LC, et al. Low maternal vitamin E intake during pregnancy is associated with asthma in 5-year-old children. Am J Respir Crit Care Med. 2006;174(5):499-507.
Devereux, G., Turner, S. W., Craig, L. C., McNeill, G., Martindale, S., Harbour, P. J., Helms, P. J., & Seaton, A. (2006). Low maternal vitamin E intake during pregnancy is associated with asthma in 5-year-old children. American Journal of Respiratory and Critical Care Medicine, 174(5), 499-507.
Devereux G, et al. Low Maternal Vitamin E Intake During Pregnancy Is Associated With Asthma in 5-year-old Children. Am J Respir Crit Care Med. 2006 Sep 1;174(5):499-507. PubMed PMID: 16763215.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Low maternal vitamin E intake during pregnancy is associated with asthma in 5-year-old children. AU - Devereux,Graham, AU - Turner,Stephen W, AU - Craig,Leone C A, AU - McNeill,Geraldine, AU - Martindale,Sheelagh, AU - Harbour,Paul J, AU - Helms,Peter J, AU - Seaton,Anthony, Y1 - 2006/06/08/ PY - 2006/6/10/pubmed PY - 2006/10/21/medline PY - 2006/6/10/entrez SP - 499 EP - 507 JF - American journal of respiratory and critical care medicine JO - Am J Respir Crit Care Med VL - 174 IS - 5 N2 - RATIONALE: We have previously reported an association between reduced maternal vitamin E intake during pregnancy and wheezing in 2-yr-old children. OBJECTIVES: To assess whether maternal nutrient intake during pregnancy is associated with asthma-related outcomes in children aged 5 yr. METHODS: A longitudinal cohort study of 1,861 children born to women recruited during pregnancy and followed up at 5 yr. MEASUREMENTS: Maternal nutrient status was assessed by a food frequency questionnaire and plasma levels. Respiratory and food frequency questionnaires were completed at 5 yr and children were invited for measurement of spirometry and skin-prick testing. MAIN RESULTS: Symptom and food frequency questionnaire data were available for 1,253 and 1,120 children, respectively; 700 children were skin prick tested, and FEV(1) was measured in 478 and exhaled nitric oxide in 167 children. In 5-yr-old children, maternal vitamin E intake during pregnancy was negatively associated with wheeze in previous year (odds ratio per intake quintile, 0.82; 95% confidence interval, 0.71-0.95), asthma ever (0.84, 0.72-0.98), asthma and wheeze in previous year (0.79, 0.65-0.95), and persistent wheezing (0.77, 0.63-0.93). Maternal plasma alpha-tocopherol during pregnancy was positively associated with post-bronchodilator FEV(1) at 5 yr, with a 7-ml (95% confidence interval, 0-14; p = 0.04) increase in FEV(1) per microg/ml alpha-tocopherol. Maternal zinc intake during pregnancy was negatively associated with asthma ever (0.83, 0.71-0.78) and active asthma (0.72, 0.59-0.89). There were no associations between children's nutrient intake and respiratory outcomes. CONCLUSION: Maternal intake of foods containing vitamin E and zinc during pregnancy is associated with differences in the risks of developing childhood wheeze and asthma. SN - 1073-449X UR - https://www.unboundmedicine.com/medline/citation/16763215/Low_maternal_vitamin_E_intake_during_pregnancy_is_associated_with_asthma_in_5_year_old_children_ L2 - https://www.atsjournals.org/doi/10.1164/rccm.200512-1946OC?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -