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Soy isoflavones attenuate bone loss in early postmenopausal Chinese women : a single-blind randomized, placebo-controlled trial.
Eur J Nutr 2006; 45(6):327-34EJ

Abstract

BACKGROUND

Previous studies show that daily doses of 40-99 mg soy isoflavones produce inconsistent effects on preventing estrogen-related bone loss in postmenopausal women.

AIM OF THE STUDY

To examined the bone-sparing effect of isoflavones at a higher dose in early Chinese postmenopausal women.

METHODS

A total of 90 eligible women aged 45-60 years were randomly assigned to three treatment groups (30 subjects/group) with daily dosages of 0 (placebo), 84 and 126 mg isoflavones for 6 months. Further inclusion criteria included body mass index <30 kg/m(2) and Kuppermann Climacteric Scale >15. Bone mineral density (BMD) of the spine and hip were measured using dual- energy X-ray absorptiometry at 0 and 6 months. Serum osteocalcin, bone-specific alkaline phosphatase (BAP) and urinary deoxypyridinoline were examined at 0, 3 and 6 months.

RESULTS

Mean percent changes in BMD at the lumbar spine (p = 0.114) and femoral neck (p = 0.053) increased with the supplementations of soy isoflavones after adjusting for age, years since menopause, body weight and height, dietary intakes of isoflavones, calcium and protein, physical activities and baseline BMD at the relevant sites. We observed significantly dose-dependent linear relationship between the supplemental isoflavones and percent changes of BMD at the spine (p = 0.042) and femoral neck (p = 0.016) post-treatment, and urinary total deoxypyridinoline (p = 0.014) at 12 weeks but not at 24 weeks after adjusting for the above factors. No significant difference in percent changes in serum osteocalcin (p > 0.05) and BAP (p > 0.05) was found among the three treatment groups at 12-week and 24-week post-treatment.

CONCLUSION

There is a significantly dose-dependent effect of soy isoflavones on attenuating bone loss at the spine and femoral neck possibly via the inhibition of bone resorption in non-obese postmenopausal Chinese women with high Kuppermann Scale.

Authors+Show Affiliations

Department of Nutrition, School of public Health Sun Yat-sen University, 74 Zhongshan Rd 2, Guangzhou, 510080, P.R. China. suyx@mail.sysu.edu.cnNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16763748

Citation

Ye, Yan-Bin, et al. "Soy Isoflavones Attenuate Bone Loss in Early Postmenopausal Chinese Women : a Single-blind Randomized, Placebo-controlled Trial." European Journal of Nutrition, vol. 45, no. 6, 2006, pp. 327-34.
Ye YB, Tang XY, Verbruggen MA, et al. Soy isoflavones attenuate bone loss in early postmenopausal Chinese women : a single-blind randomized, placebo-controlled trial. Eur J Nutr. 2006;45(6):327-34.
Ye, Y. B., Tang, X. Y., Verbruggen, M. A., & Su, Y. X. (2006). Soy isoflavones attenuate bone loss in early postmenopausal Chinese women : a single-blind randomized, placebo-controlled trial. European Journal of Nutrition, 45(6), pp. 327-34.
Ye YB, et al. Soy Isoflavones Attenuate Bone Loss in Early Postmenopausal Chinese Women : a Single-blind Randomized, Placebo-controlled Trial. Eur J Nutr. 2006;45(6):327-34. PubMed PMID: 16763748.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Soy isoflavones attenuate bone loss in early postmenopausal Chinese women : a single-blind randomized, placebo-controlled trial. AU - Ye,Yan-Bin, AU - Tang,Xing-Yi, AU - Verbruggen,Marian A, AU - Su,Yi-Xiang, Y1 - 2006/06/08/ PY - 2005/11/08/received PY - 2006/04/28/accepted PY - 2006/6/10/pubmed PY - 2007/2/9/medline PY - 2006/6/10/entrez SP - 327 EP - 34 JF - European journal of nutrition JO - Eur J Nutr VL - 45 IS - 6 N2 - BACKGROUND: Previous studies show that daily doses of 40-99 mg soy isoflavones produce inconsistent effects on preventing estrogen-related bone loss in postmenopausal women. AIM OF THE STUDY: To examined the bone-sparing effect of isoflavones at a higher dose in early Chinese postmenopausal women. METHODS: A total of 90 eligible women aged 45-60 years were randomly assigned to three treatment groups (30 subjects/group) with daily dosages of 0 (placebo), 84 and 126 mg isoflavones for 6 months. Further inclusion criteria included body mass index <30 kg/m(2) and Kuppermann Climacteric Scale >15. Bone mineral density (BMD) of the spine and hip were measured using dual- energy X-ray absorptiometry at 0 and 6 months. Serum osteocalcin, bone-specific alkaline phosphatase (BAP) and urinary deoxypyridinoline were examined at 0, 3 and 6 months. RESULTS: Mean percent changes in BMD at the lumbar spine (p = 0.114) and femoral neck (p = 0.053) increased with the supplementations of soy isoflavones after adjusting for age, years since menopause, body weight and height, dietary intakes of isoflavones, calcium and protein, physical activities and baseline BMD at the relevant sites. We observed significantly dose-dependent linear relationship between the supplemental isoflavones and percent changes of BMD at the spine (p = 0.042) and femoral neck (p = 0.016) post-treatment, and urinary total deoxypyridinoline (p = 0.014) at 12 weeks but not at 24 weeks after adjusting for the above factors. No significant difference in percent changes in serum osteocalcin (p > 0.05) and BAP (p > 0.05) was found among the three treatment groups at 12-week and 24-week post-treatment. CONCLUSION: There is a significantly dose-dependent effect of soy isoflavones on attenuating bone loss at the spine and femoral neck possibly via the inhibition of bone resorption in non-obese postmenopausal Chinese women with high Kuppermann Scale. SN - 1436-6207 UR - https://www.unboundmedicine.com/medline/citation/16763748/Soy_isoflavones_attenuate_bone_loss_in_early_postmenopausal_Chinese_women_:_a_single_blind_randomized_placebo_controlled_trial_ L2 - https://dx.doi.org/10.1007/s00394-006-0602-2 DB - PRIME DP - Unbound Medicine ER -