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Impact of different saturated fatty acid, polyunsaturated fatty acid and cholesterol containing diets on beta-amyloid accumulation in APP/PS1 transgenic mice.
Neurobiol Dis 2006; 23(3):563-72ND

Abstract

The present study assessed the influence of dietary lipids on accumulation of amyloid beta-peptide (Abeta) in the brain. Seven experimental diets with varying n-6/n-3-ratio, saturated and polyunsaturated fatty acid and cholesterol contents were fed to transgenic APPswe/PS1dE9 mice for 3-4 months beginning at a young adult age (6 months). Hippocampal Abeta levels were determined with ELISA and plaque load by using immunocytochemistry. A typical Western diet with 40% saturated fatty acids and 1% of cholesterol increased, while diets supplemented with docosahexaenoic acid (DHA) decreased Abeta levels compared to regular (soy oil based) diet. DHA diet also decreased the number of activated microglia in hippocampus and increased exploratory activity of transgenic mice, but did not improve their spatial learning in the water maze. The favorable effect of DHA on Abeta production was verified in two different cell lines. Regulation of dietary lipid intake may offer a new tool to reduce the risk of Alzheimer's disease at the population level.

Authors+Show Affiliations

Department of Neuroscience and Neurology, University of Kuopio, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16765602

Citation

Oksman, M, et al. "Impact of Different Saturated Fatty Acid, Polyunsaturated Fatty Acid and Cholesterol Containing Diets On Beta-amyloid Accumulation in APP/PS1 Transgenic Mice." Neurobiology of Disease, vol. 23, no. 3, 2006, pp. 563-72.
Oksman M, Iivonen H, Hogyes E, et al. Impact of different saturated fatty acid, polyunsaturated fatty acid and cholesterol containing diets on beta-amyloid accumulation in APP/PS1 transgenic mice. Neurobiol Dis. 2006;23(3):563-72.
Oksman, M., Iivonen, H., Hogyes, E., Amtul, Z., Penke, B., Leenders, I., ... Tanila, H. (2006). Impact of different saturated fatty acid, polyunsaturated fatty acid and cholesterol containing diets on beta-amyloid accumulation in APP/PS1 transgenic mice. Neurobiology of Disease, 23(3), pp. 563-72.
Oksman M, et al. Impact of Different Saturated Fatty Acid, Polyunsaturated Fatty Acid and Cholesterol Containing Diets On Beta-amyloid Accumulation in APP/PS1 Transgenic Mice. Neurobiol Dis. 2006;23(3):563-72. PubMed PMID: 16765602.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of different saturated fatty acid, polyunsaturated fatty acid and cholesterol containing diets on beta-amyloid accumulation in APP/PS1 transgenic mice. AU - Oksman,M, AU - Iivonen,H, AU - Hogyes,E, AU - Amtul,Z, AU - Penke,B, AU - Leenders,I, AU - Broersen,L, AU - Lütjohann,D, AU - Hartmann,T, AU - Tanila,H, Y1 - 2006/06/12/ PY - 2005/11/04/received PY - 2006/03/19/revised PY - 2006/04/24/accepted PY - 2006/6/13/pubmed PY - 2006/11/2/medline PY - 2006/6/13/entrez SP - 563 EP - 72 JF - Neurobiology of disease JO - Neurobiol. Dis. VL - 23 IS - 3 N2 - The present study assessed the influence of dietary lipids on accumulation of amyloid beta-peptide (Abeta) in the brain. Seven experimental diets with varying n-6/n-3-ratio, saturated and polyunsaturated fatty acid and cholesterol contents were fed to transgenic APPswe/PS1dE9 mice for 3-4 months beginning at a young adult age (6 months). Hippocampal Abeta levels were determined with ELISA and plaque load by using immunocytochemistry. A typical Western diet with 40% saturated fatty acids and 1% of cholesterol increased, while diets supplemented with docosahexaenoic acid (DHA) decreased Abeta levels compared to regular (soy oil based) diet. DHA diet also decreased the number of activated microglia in hippocampus and increased exploratory activity of transgenic mice, but did not improve their spatial learning in the water maze. The favorable effect of DHA on Abeta production was verified in two different cell lines. Regulation of dietary lipid intake may offer a new tool to reduce the risk of Alzheimer's disease at the population level. SN - 0969-9961 UR - https://www.unboundmedicine.com/medline/citation/16765602/Impact_of_different_saturated_fatty_acid_polyunsaturated_fatty_acid_and_cholesterol_containing_diets_on_beta_amyloid_accumulation_in_APP/PS1_transgenic_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0969-9961(06)00100-8 DB - PRIME DP - Unbound Medicine ER -