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The effect of timolol-dorzolamide and timolol-pilocarpine combinations on ocular blood flow in patients with glaucoma.
Am J Ophthalmol. 2006 Jun; 141(6):1158-60.AJ

Abstract

PURPOSE

To investigate the effect of timolol-dorzolamide and timolol-pilocarpine fixed combinations on retrobulbar vessel blood flow.

DESIGN

Prospective, randomized, masked, crossover clinical trial.

METHODS

Sixteen patients with primary open angle glaucoma, treated with timolol 0.5%, received timolol 0.5%-dorzolamide 2% and timolol 0.5%-pilocarpine 2% for four weeks each. Heart rate, blood pressure, intraocular pressure (IOP), and peak systolic (PSV) and end diastolic velocities (EDV) in ophthalmic, central retinal, and short posterior ciliary arteries were measured before and after each treatment, and resistivity index was calculated.

RESULTS

The IOP was reduced (P < .01) by timolol-dorzolamide and, more effectively, timolol-pilocarpine combinations. In central retinal artery, the end diastolic velocity was increased by the timolol-dorzolamide combination (P < .01), resulting in higher end diastolic velocity and lower resistivity index values (both P < .01) compared with the timolol-pilocarpine combination.

CONCLUSIONS

The timolol-dorzolamide combination increases the end diastolic velocity in central retinal artery, despite a lower intraocular pressure decrease, suggesting an effect on retinal circulation.

Authors+Show Affiliations

Sezione di Oftalmologia, Dipartimento di Specialità Medico-Chirurgiche, Università di Catania, Italy. Clinica.Oculistica@mbox.unict.itNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16765700

Citation

Uva, Maurizio G., et al. "The Effect of Timolol-dorzolamide and Timolol-pilocarpine Combinations On Ocular Blood Flow in Patients With Glaucoma." American Journal of Ophthalmology, vol. 141, no. 6, 2006, pp. 1158-60.
Uva MG, Longo A, Reibaldi M, et al. The effect of timolol-dorzolamide and timolol-pilocarpine combinations on ocular blood flow in patients with glaucoma. Am J Ophthalmol. 2006;141(6):1158-60.
Uva, M. G., Longo, A., Reibaldi, M., & Reibaldi, A. (2006). The effect of timolol-dorzolamide and timolol-pilocarpine combinations on ocular blood flow in patients with glaucoma. American Journal of Ophthalmology, 141(6), 1158-60.
Uva MG, et al. The Effect of Timolol-dorzolamide and Timolol-pilocarpine Combinations On Ocular Blood Flow in Patients With Glaucoma. Am J Ophthalmol. 2006;141(6):1158-60. PubMed PMID: 16765700.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of timolol-dorzolamide and timolol-pilocarpine combinations on ocular blood flow in patients with glaucoma. AU - Uva,Maurizio G, AU - Longo,Antonio, AU - Reibaldi,Michele, AU - Reibaldi,Alfredo, PY - 2005/06/10/received PY - 2005/12/29/revised PY - 2006/01/13/accepted PY - 2006/6/13/pubmed PY - 2006/7/11/medline PY - 2006/6/13/entrez SP - 1158 EP - 60 JF - American journal of ophthalmology JO - Am J Ophthalmol VL - 141 IS - 6 N2 - PURPOSE: To investigate the effect of timolol-dorzolamide and timolol-pilocarpine fixed combinations on retrobulbar vessel blood flow. DESIGN: Prospective, randomized, masked, crossover clinical trial. METHODS: Sixteen patients with primary open angle glaucoma, treated with timolol 0.5%, received timolol 0.5%-dorzolamide 2% and timolol 0.5%-pilocarpine 2% for four weeks each. Heart rate, blood pressure, intraocular pressure (IOP), and peak systolic (PSV) and end diastolic velocities (EDV) in ophthalmic, central retinal, and short posterior ciliary arteries were measured before and after each treatment, and resistivity index was calculated. RESULTS: The IOP was reduced (P < .01) by timolol-dorzolamide and, more effectively, timolol-pilocarpine combinations. In central retinal artery, the end diastolic velocity was increased by the timolol-dorzolamide combination (P < .01), resulting in higher end diastolic velocity and lower resistivity index values (both P < .01) compared with the timolol-pilocarpine combination. CONCLUSIONS: The timolol-dorzolamide combination increases the end diastolic velocity in central retinal artery, despite a lower intraocular pressure decrease, suggesting an effect on retinal circulation. SN - 0002-9394 UR - https://www.unboundmedicine.com/medline/citation/16765700/The_effect_of_timolol_dorzolamide_and_timolol_pilocarpine_combinations_on_ocular_blood_flow_in_patients_with_glaucoma_ DB - PRIME DP - Unbound Medicine ER -