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An open study to assess the efficacy clinically and immunologically of M. vaccae vaccine in patients with atopic dermatitis.
J Dermatolog Treat 2006; 17(2):74-7JD

Abstract

OBJECTIVE

To assess clinical and immunological changes in a group of atopic dermatitis patients treated with Mycobacterium vaccae (M. vaccae).

METHODS

In an open, randomized, placebo-controlled, clinical observer-blinded trial, 20 patients with moderately severe to severe atopic dermatitis were treated with two subcutaneous M. vaccae injections 3 months apart. Clinical scoring and total serum IgE estimation were performed at the start, during and 3 months after the end of the study.

RESULTS

Modest clinical improvement was seen in the patients after M. vaccae immunotherapy. There was no significant change in patients' total serum IgE levels.

CONCLUSIONS

This study has shown limited improvement clinically in a group of patients with atopic dermatitis treated with two M. vaccae injections. It is suggested that further trials using four to six injections would produce much greater benefit.

Authors+Show Affiliations

Department of Dermatology, Derriford Hospital, Plymouth, UK. pauline.slater@phnt.swest.nhs.ukNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

16766329

Citation

Davies, Michael G., et al. "An Open Study to Assess the Efficacy Clinically and Immunologically of M. Vaccae Vaccine in Patients With Atopic Dermatitis." The Journal of Dermatological Treatment, vol. 17, no. 2, 2006, pp. 74-7.
Davies MG, Symons C, Shaw S, et al. An open study to assess the efficacy clinically and immunologically of M. vaccae vaccine in patients with atopic dermatitis. J Dermatolog Treat. 2006;17(2):74-7.
Davies, M. G., Symons, C., Shaw, S., & Kaminski, E. R. (2006). An open study to assess the efficacy clinically and immunologically of M. vaccae vaccine in patients with atopic dermatitis. The Journal of Dermatological Treatment, 17(2), pp. 74-7.
Davies MG, et al. An Open Study to Assess the Efficacy Clinically and Immunologically of M. Vaccae Vaccine in Patients With Atopic Dermatitis. J Dermatolog Treat. 2006;17(2):74-7. PubMed PMID: 16766329.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An open study to assess the efficacy clinically and immunologically of M. vaccae vaccine in patients with atopic dermatitis. AU - Davies,Michael G, AU - Symons,Christine, AU - Shaw,Stephen, AU - Kaminski,Eduardo R, PY - 2006/6/13/pubmed PY - 2006/6/28/medline PY - 2006/6/13/entrez SP - 74 EP - 7 JF - The Journal of dermatological treatment JO - J Dermatolog Treat VL - 17 IS - 2 N2 - OBJECTIVE: To assess clinical and immunological changes in a group of atopic dermatitis patients treated with Mycobacterium vaccae (M. vaccae). METHODS: In an open, randomized, placebo-controlled, clinical observer-blinded trial, 20 patients with moderately severe to severe atopic dermatitis were treated with two subcutaneous M. vaccae injections 3 months apart. Clinical scoring and total serum IgE estimation were performed at the start, during and 3 months after the end of the study. RESULTS: Modest clinical improvement was seen in the patients after M. vaccae immunotherapy. There was no significant change in patients' total serum IgE levels. CONCLUSIONS: This study has shown limited improvement clinically in a group of patients with atopic dermatitis treated with two M. vaccae injections. It is suggested that further trials using four to six injections would produce much greater benefit. SN - 0954-6634 UR - https://www.unboundmedicine.com/medline/citation/16766329/An_open_study_to_assess_the_efficacy_clinically_and_immunologically_of_M__vaccae_vaccine_in_patients_with_atopic_dermatitis_ L2 - http://www.tandfonline.com/doi/full/10.1080/09546630500515321 DB - PRIME DP - Unbound Medicine ER -