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A randomized, investigator-masked clinical evaluation of the efficacy and safety of clobetasol propionate 0.05% shampoo and tar blend 1% shampoo in the treatment of moderate to severe scalp psoriasis.
J Dermatolog Treat. 2006; 17(2):90-5.JD

Abstract

The clinical benefit of currently available tar blend shampoos for the treatment of scalp psoriasis is restricted due to their limited efficacy, low cosmetic appeal and potential for carcinogenicity. This 4-week multicentre, randomized, parallel-group, investigator-masked study included 162 subjects and aimed to compare the efficacy, safety and cosmetic acceptability of clobetasol propionate 0.05% shampoo versus a currently marketed tar blend 1% shampoo in subjects with moderate to severe scalp psoriasis. Clobetasol propionate shampoo was superior to tar blend shampoo with respect to all efficacy variables tested (p<0.001): Total and Global Severity Score; erythema; plaque thickening; desquamation; pruritus; total scalp area involved; and the subject's global assessment of clinical improvement. Both treatments were safe and well-tolerated. Furthermore, more subjects indicated that clobetasol propionate shampoo was more cosmetically acceptable than tar blend shampoo. Clobetasol propionate 0.05% shampoo is a good alternative to tar blend shampoo in the treatment of moderate to severe scalp psoriasis.

Authors+Show Affiliations

Griffiths CE
Dermatology Centre, Hope Hospital, University of Manchester, Manchester, UK.
Finlay AY
No affiliation info available
Fleming CJ
No affiliation info available
Barker JN
No affiliation info available
Mizzi F
No affiliation info available
Arsonnaud S
No affiliation info available

MeSH

Administration, CutaneousClobetasolDouble-Blind MethodFemaleHair PreparationsHumansKeratolytic AgentsMaleMiddle AgedPsoriasisScalp DermatosesSeverity of Illness IndexTarsTreatment Outcome

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

16766333

Citation

Griffiths, Christopher E M., et al. "A Randomized, Investigator-masked Clinical Evaluation of the Efficacy and Safety of Clobetasol Propionate 0.05% Shampoo and Tar Blend 1% Shampoo in the Treatment of Moderate to Severe Scalp Psoriasis." The Journal of Dermatological Treatment, vol. 17, no. 2, 2006, pp. 90-5.
Griffiths CE, Finlay AY, Fleming CJ, et al. A randomized, investigator-masked clinical evaluation of the efficacy and safety of clobetasol propionate 0.05% shampoo and tar blend 1% shampoo in the treatment of moderate to severe scalp psoriasis. J Dermatolog Treat. 2006;17(2):90-5.
Griffiths, C. E., Finlay, A. Y., Fleming, C. J., Barker, J. N., Mizzi, F., & Arsonnaud, S. (2006). A randomized, investigator-masked clinical evaluation of the efficacy and safety of clobetasol propionate 0.05% shampoo and tar blend 1% shampoo in the treatment of moderate to severe scalp psoriasis. The Journal of Dermatological Treatment, 17(2), 90-5.
Griffiths CE, et al. A Randomized, Investigator-masked Clinical Evaluation of the Efficacy and Safety of Clobetasol Propionate 0.05% Shampoo and Tar Blend 1% Shampoo in the Treatment of Moderate to Severe Scalp Psoriasis. J Dermatolog Treat. 2006;17(2):90-5. PubMed PMID: 16766333.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A randomized, investigator-masked clinical evaluation of the efficacy and safety of clobetasol propionate 0.05% shampoo and tar blend 1% shampoo in the treatment of moderate to severe scalp psoriasis. AU - Griffiths,Christopher E M, AU - Finlay,Andrew Y, AU - Fleming,Colin J, AU - Barker,Jonathan N W N, AU - Mizzi,Fabienne, AU - Arsonnaud,Stéphanie, PY - 2006/6/13/pubmed PY - 2006/6/28/medline PY - 2006/6/13/entrez SP - 90 EP - 5 JF - The Journal of dermatological treatment JO - J Dermatolog Treat VL - 17 IS - 2 N2 - The clinical benefit of currently available tar blend shampoos for the treatment of scalp psoriasis is restricted due to their limited efficacy, low cosmetic appeal and potential for carcinogenicity. This 4-week multicentre, randomized, parallel-group, investigator-masked study included 162 subjects and aimed to compare the efficacy, safety and cosmetic acceptability of clobetasol propionate 0.05% shampoo versus a currently marketed tar blend 1% shampoo in subjects with moderate to severe scalp psoriasis. Clobetasol propionate shampoo was superior to tar blend shampoo with respect to all efficacy variables tested (p<0.001): Total and Global Severity Score; erythema; plaque thickening; desquamation; pruritus; total scalp area involved; and the subject's global assessment of clinical improvement. Both treatments were safe and well-tolerated. Furthermore, more subjects indicated that clobetasol propionate shampoo was more cosmetically acceptable than tar blend shampoo. Clobetasol propionate 0.05% shampoo is a good alternative to tar blend shampoo in the treatment of moderate to severe scalp psoriasis. SN - 0954-6634 UR - https://www.unboundmedicine.com/medline/citation/16766333/A_randomized_investigator_masked_clinical_evaluation_of_the_efficacy_and_safety_of_clobetasol_propionate_0_05_shampoo_and_tar_blend_1_shampoo_in_the_treatment_of_moderate_to_severe_scalp_psoriasis_ DB - PRIME DP - Unbound Medicine ER -