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Differential prevalence of quality-of-life categories (domains) in Asian women and changes after therapy with three doses of conjugated estrogens/medroxyprogesterone acetate: the Pan-Asia Menopause (PAM) study.
Climacteric. 2006 Jun; 9(3):204-14.C

Abstract

OBJECTIVES

To assess the prevalence of four categories (domains) of menopausal symptoms as markers for quality of life in nine ethnic groups of Asian women. To evaluate changes in quality of life (MENQOL scores) in Asian women following hormone therapy.

METHODS

A prospective, randomized, double-blind, multinational clinical trial in 1028 healthy postmenopausal women of nine ethnic groups from 11 Asian countries/regions. Following 2 weeks of baseline observation, the women received one of three conjugated estrogens (CE)/medroxyprogesterone acetate (MPA) doses (in mg) daily for 24 weeks: 0.625/2.5, 0.45/1.5, or 0.3/1.5. At baseline and at the end of weeks 4, 12 and 24 following the start of therapy, the study participants were asked to record, on a menopause-specific quality of life (MENQOL) questionnaire, 29 menopausal symptoms, as experienced during the preceding month. The symptoms were categorized into four domains: vasomotor, psychosocial, physical and sexual.

RESULTS

The baseline (pretreatment) symptom scores in each of the four domains varied substantially among the different ethnic groups, ranging from 2.21 to 5.71 in the vasomotor, 2.37-5.96 in the psychosocial, 2.66-5.39 in the physical, and 2.11-6.55 in the sexual domain. Overall, Vietnamese and Pakistani women had the highest baseline scores, i.e. were most afflicted by each set of symptoms in a given domain, and Indonesian, Malay, Taiwanese and Thai women were least afflicted. In the overall population, intervention resulted in statistically significant decreases in the scores of all four domains within 4 weeks of intervention. The beneficial effects were similar in the three dose groups.

CONCLUSIONS

The prevalence of four domains of menopausal symptoms, representative of quality of life as recorded on a MENQOL questionnaire, varies considerably among ethnic groups of Asian women. The MENQOL scores in the overall population were significantly lowered in the course of the study, indicating an improvement in quality of life. In the absence of a placebo group, the relative contribution of hormones and placebo in our intervention is unknown.

Authors+Show Affiliations

Chulalongkorn University, Bangkok, Thailand.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16766434

Citation

Limpaphayom, K K., et al. "Differential Prevalence of Quality-of-life Categories (domains) in Asian Women and Changes After Therapy With Three Doses of Conjugated Estrogens/medroxyprogesterone Acetate: the Pan-Asia Menopause (PAM) Study." Climacteric : the Journal of the International Menopause Society, vol. 9, no. 3, 2006, pp. 204-14.
Limpaphayom KK, Darmasetiawan MS, Hussain RI, et al. Differential prevalence of quality-of-life categories (domains) in Asian women and changes after therapy with three doses of conjugated estrogens/medroxyprogesterone acetate: the Pan-Asia Menopause (PAM) study. Climacteric. 2006;9(3):204-14.
Limpaphayom, K. K., Darmasetiawan, M. S., Hussain, R. I., Burriss, S. W., Holinka, C. F., & Ausmanas, M. K. (2006). Differential prevalence of quality-of-life categories (domains) in Asian women and changes after therapy with three doses of conjugated estrogens/medroxyprogesterone acetate: the Pan-Asia Menopause (PAM) study. Climacteric : the Journal of the International Menopause Society, 9(3), 204-14.
Limpaphayom KK, et al. Differential Prevalence of Quality-of-life Categories (domains) in Asian Women and Changes After Therapy With Three Doses of Conjugated Estrogens/medroxyprogesterone Acetate: the Pan-Asia Menopause (PAM) Study. Climacteric. 2006;9(3):204-14. PubMed PMID: 16766434.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differential prevalence of quality-of-life categories (domains) in Asian women and changes after therapy with three doses of conjugated estrogens/medroxyprogesterone acetate: the Pan-Asia Menopause (PAM) study. AU - Limpaphayom,K K, AU - Darmasetiawan,M S, AU - Hussain,R I, AU - Burriss,S W, AU - Holinka,C F, AU - Ausmanas,M K, PY - 2006/6/13/pubmed PY - 2007/10/27/medline PY - 2006/6/13/entrez SP - 204 EP - 14 JF - Climacteric : the journal of the International Menopause Society JO - Climacteric VL - 9 IS - 3 N2 - OBJECTIVES: To assess the prevalence of four categories (domains) of menopausal symptoms as markers for quality of life in nine ethnic groups of Asian women. To evaluate changes in quality of life (MENQOL scores) in Asian women following hormone therapy. METHODS: A prospective, randomized, double-blind, multinational clinical trial in 1028 healthy postmenopausal women of nine ethnic groups from 11 Asian countries/regions. Following 2 weeks of baseline observation, the women received one of three conjugated estrogens (CE)/medroxyprogesterone acetate (MPA) doses (in mg) daily for 24 weeks: 0.625/2.5, 0.45/1.5, or 0.3/1.5. At baseline and at the end of weeks 4, 12 and 24 following the start of therapy, the study participants were asked to record, on a menopause-specific quality of life (MENQOL) questionnaire, 29 menopausal symptoms, as experienced during the preceding month. The symptoms were categorized into four domains: vasomotor, psychosocial, physical and sexual. RESULTS: The baseline (pretreatment) symptom scores in each of the four domains varied substantially among the different ethnic groups, ranging from 2.21 to 5.71 in the vasomotor, 2.37-5.96 in the psychosocial, 2.66-5.39 in the physical, and 2.11-6.55 in the sexual domain. Overall, Vietnamese and Pakistani women had the highest baseline scores, i.e. were most afflicted by each set of symptoms in a given domain, and Indonesian, Malay, Taiwanese and Thai women were least afflicted. In the overall population, intervention resulted in statistically significant decreases in the scores of all four domains within 4 weeks of intervention. The beneficial effects were similar in the three dose groups. CONCLUSIONS: The prevalence of four domains of menopausal symptoms, representative of quality of life as recorded on a MENQOL questionnaire, varies considerably among ethnic groups of Asian women. The MENQOL scores in the overall population were significantly lowered in the course of the study, indicating an improvement in quality of life. In the absence of a placebo group, the relative contribution of hormones and placebo in our intervention is unknown. SN - 1369-7137 UR - https://www.unboundmedicine.com/medline/citation/16766434/Differential_prevalence_of_quality_of_life_categories__domains__in_Asian_women_and_changes_after_therapy_with_three_doses_of_conjugated_estrogens/medroxyprogesterone_acetate:_the_Pan_Asia_Menopause__PAM__study_ L2 - https://www.tandfonline.com/doi/full/10.1080/13697130600722520 DB - PRIME DP - Unbound Medicine ER -