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The effect of 2% niacinamide on facial sebum production.
J Cosmet Laser Ther 2006; 8(2):96-101JC

Abstract

BACKGROUND

The presence of sebum on the face is responsible for both facial shine and the formation of comedonal and inflammatory acne lesions. Sebum control is a goal of many OTC skin care products; however, most currently available products function by absorbing sebum from the face rather than modulating its production.

OBJECTIVE

To demonstrate the effect of topical 2% niacinamide on sebum excretion rates and casual sebum production in Oriental and Caucasian populations.

METHODS

Separate clinical trials were conducted in both Japan and the USA to evaluate the effect of topical 2% niacinamide in different ethnic groups. A total of 100 Japanese subjects were enrolled in a double-blind, placebo-controlled comparison between two independent balanced groups. Fifty subjects applied the 2% niacinamide moisturizer to the face for 4 weeks and 50 subjects used a placebo moisturizer for 4 weeks, with sebum excretion rate (SER) measurements taken at baseline, week 2, and week 4. In addition, 30 Caucasian subjects were enrolled in a randomized split-face study for 6 weeks with SER and casual sebum levels (CSL) measured at baseline, week 3, and week 6.

RESULTS

The results of the Japanese study demonstrated that the SER of the two groups was not significantly different at baseline, but the 2% niacinamide treated group demonstrated significantly lowered SER after 2 and 4 weeks of application. The results were somewhat different in the Caucasian study. After 6 weeks of treatment, the CSL was significantly reduced, but the SER was not significantly reduced.

CONCLUSIONS

Topical 2% niacinamide may be effective in lowering the SER in Japanese individuals and CSL in Caucasian individuals.

Authors+Show Affiliations

Department of Dermatology, Wake Forest University School of Medicine, Winston-Salem, NC 27262, USA. zdraelos@northstate.netNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

16766489

Citation

Draelos, Zoe Diana, et al. "The Effect of 2% Niacinamide On Facial Sebum Production." Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology, vol. 8, no. 2, 2006, pp. 96-101.
Draelos ZD, Matsubara A, Smiles K. The effect of 2% niacinamide on facial sebum production. J Cosmet Laser Ther. 2006;8(2):96-101.
Draelos, Z. D., Matsubara, A., & Smiles, K. (2006). The effect of 2% niacinamide on facial sebum production. Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology, 8(2), pp. 96-101.
Draelos ZD, Matsubara A, Smiles K. The Effect of 2% Niacinamide On Facial Sebum Production. J Cosmet Laser Ther. 2006;8(2):96-101. PubMed PMID: 16766489.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of 2% niacinamide on facial sebum production. AU - Draelos,Zoe Diana, AU - Matsubara,Akira, AU - Smiles,Kenneth, PY - 2006/6/13/pubmed PY - 2006/8/17/medline PY - 2006/6/13/entrez SP - 96 EP - 101 JF - Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology JO - J Cosmet Laser Ther VL - 8 IS - 2 N2 - BACKGROUND: The presence of sebum on the face is responsible for both facial shine and the formation of comedonal and inflammatory acne lesions. Sebum control is a goal of many OTC skin care products; however, most currently available products function by absorbing sebum from the face rather than modulating its production. OBJECTIVE: To demonstrate the effect of topical 2% niacinamide on sebum excretion rates and casual sebum production in Oriental and Caucasian populations. METHODS: Separate clinical trials were conducted in both Japan and the USA to evaluate the effect of topical 2% niacinamide in different ethnic groups. A total of 100 Japanese subjects were enrolled in a double-blind, placebo-controlled comparison between two independent balanced groups. Fifty subjects applied the 2% niacinamide moisturizer to the face for 4 weeks and 50 subjects used a placebo moisturizer for 4 weeks, with sebum excretion rate (SER) measurements taken at baseline, week 2, and week 4. In addition, 30 Caucasian subjects were enrolled in a randomized split-face study for 6 weeks with SER and casual sebum levels (CSL) measured at baseline, week 3, and week 6. RESULTS: The results of the Japanese study demonstrated that the SER of the two groups was not significantly different at baseline, but the 2% niacinamide treated group demonstrated significantly lowered SER after 2 and 4 weeks of application. The results were somewhat different in the Caucasian study. After 6 weeks of treatment, the CSL was significantly reduced, but the SER was not significantly reduced. CONCLUSIONS: Topical 2% niacinamide may be effective in lowering the SER in Japanese individuals and CSL in Caucasian individuals. SN - 1476-4172 UR - https://www.unboundmedicine.com/medline/citation/16766489/The_effect_of_2_niacinamide_on_facial_sebum_production_ L2 - http://www.tandfonline.com/doi/full/10.1080/14764170600717704 DB - PRIME DP - Unbound Medicine ER -