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Peginterferon alfa-2a (40KD) (PEGASYS) plus ribavirin (COPEGUS) in retreatment of chronic hepatitis C patients, nonresponders and relapsers to previous conventional interferon plus ribavirin therapy.
Braz J Infect Dis. 2006 Feb; 10(1):11-6.BJ

Abstract

Peginterferon alfa plus ribavirin is currently the treatment of choice for chronic hepatitis C. Peginterferon alfa-2a (40KD) plus ribavirin has given an overall sustained virological response of 18% in F3/F4 previous nonresponder US patients. We evaluated the effectiveness of peginterferon alfa-2a (40KD) plus ribavirin in Brazilian patients who were relapsers or nonresponders to previous interferon-based therapy. One-hundred-thirty-four patients with biopsy-proven chronic hepatitis C, HCV RNA positive, elevated ALT and who were either relapsers (n=37) or nonresponders (n=97) to at least 24 weeks of conventional interferon/ribavirin therapy were retreated with peginterferon alfa-2a (40KD) 180mg/qw and ribavirin 800 mg bid for 48 weeks. Efficacy was assessed as virological response (defined as undetectable HCV RNA) at the end of treatment (EoT) and at the end of follow-up (SVR - Sustained Virological Response). Safety assessments consisted of clinical and laboratory evaluations. In the patient sample, 72% were genotype 1 and 34% were cirrhotic. In an intention-to-treat analysis, relapser patients showed 78% EoT response and 51% SVR. Nonresponders showed 57% EoT response and 26% SVR. Positive predictive factors of SVR were non-1 genotype and relapser state. Six percent of the patients interrupted treatment because of adverse events and 45% had dose reduction (mainly associated with leucopenia and anemia). Brazilian patient relapsers and nonresponders to conventional interferon and ribavirin treatment can achieve a sustained virological response when retreated with peginterferon alfa-2a (40KD) and ribavirin. The safety profile is similar to that of naive patients.

Authors+Show Affiliations

Federal University of São Paulo, São Paulo, SP, Brazil. parise@gastro.epm.brNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16767309

Citation

Parise, E, et al. "Peginterferon Alfa-2a (40KD) (PEGASYS) Plus Ribavirin (COPEGUS) in Retreatment of Chronic Hepatitis C Patients, Nonresponders and Relapsers to Previous Conventional Interferon Plus Ribavirin Therapy." The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases, vol. 10, no. 1, 2006, pp. 11-6.
Parise E, Cheinquer H, Crespo D, et al. Peginterferon alfa-2a (40KD) (PEGASYS) plus ribavirin (COPEGUS) in retreatment of chronic hepatitis C patients, nonresponders and relapsers to previous conventional interferon plus ribavirin therapy. Braz J Infect Dis. 2006;10(1):11-6.
Parise, E., Cheinquer, H., Crespo, D., Meirelles, A., Martinelli, A., Sette, H., Gallizi, J., Silva, R., Lacet, C., Correa, E., Cotrim, H., Fonseca, J., Paraná, R., Spinelli, V., Amorim, W., Tatsch, F., & Pessoa, M. (2006). Peginterferon alfa-2a (40KD) (PEGASYS) plus ribavirin (COPEGUS) in retreatment of chronic hepatitis C patients, nonresponders and relapsers to previous conventional interferon plus ribavirin therapy. The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases, 10(1), 11-6.
Parise E, et al. Peginterferon Alfa-2a (40KD) (PEGASYS) Plus Ribavirin (COPEGUS) in Retreatment of Chronic Hepatitis C Patients, Nonresponders and Relapsers to Previous Conventional Interferon Plus Ribavirin Therapy. Braz J Infect Dis. 2006;10(1):11-6. PubMed PMID: 16767309.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Peginterferon alfa-2a (40KD) (PEGASYS) plus ribavirin (COPEGUS) in retreatment of chronic hepatitis C patients, nonresponders and relapsers to previous conventional interferon plus ribavirin therapy. AU - Parise,E, AU - Cheinquer,H, AU - Crespo,D, AU - Meirelles,A, AU - Martinelli,A, AU - Sette,H, AU - Gallizi,J, AU - Silva,R, AU - Lacet,C, AU - Correa,E, AU - Cotrim,H, AU - Fonseca,J, AU - Paraná,R, AU - Spinelli,V, AU - Amorim,W, AU - Tatsch,F, AU - Pessoa,M, AU - ,, Y1 - 2006/06/02/ PY - 2006/6/13/pubmed PY - 2006/12/9/medline PY - 2006/6/13/entrez SP - 11 EP - 6 JF - The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases JO - Braz J Infect Dis VL - 10 IS - 1 N2 - Peginterferon alfa plus ribavirin is currently the treatment of choice for chronic hepatitis C. Peginterferon alfa-2a (40KD) plus ribavirin has given an overall sustained virological response of 18% in F3/F4 previous nonresponder US patients. We evaluated the effectiveness of peginterferon alfa-2a (40KD) plus ribavirin in Brazilian patients who were relapsers or nonresponders to previous interferon-based therapy. One-hundred-thirty-four patients with biopsy-proven chronic hepatitis C, HCV RNA positive, elevated ALT and who were either relapsers (n=37) or nonresponders (n=97) to at least 24 weeks of conventional interferon/ribavirin therapy were retreated with peginterferon alfa-2a (40KD) 180mg/qw and ribavirin 800 mg bid for 48 weeks. Efficacy was assessed as virological response (defined as undetectable HCV RNA) at the end of treatment (EoT) and at the end of follow-up (SVR - Sustained Virological Response). Safety assessments consisted of clinical and laboratory evaluations. In the patient sample, 72% were genotype 1 and 34% were cirrhotic. In an intention-to-treat analysis, relapser patients showed 78% EoT response and 51% SVR. Nonresponders showed 57% EoT response and 26% SVR. Positive predictive factors of SVR were non-1 genotype and relapser state. Six percent of the patients interrupted treatment because of adverse events and 45% had dose reduction (mainly associated with leucopenia and anemia). Brazilian patient relapsers and nonresponders to conventional interferon and ribavirin treatment can achieve a sustained virological response when retreated with peginterferon alfa-2a (40KD) and ribavirin. The safety profile is similar to that of naive patients. SN - 1413-8670 UR - https://www.unboundmedicine.com/medline/citation/16767309/Peginterferon_alfa_2a__40KD___PEGASYS__plus_ribavirin__COPEGUS__in_retreatment_of_chronic_hepatitis_C_patients_nonresponders_and_relapsers_to_previous_conventional_interferon_plus_ribavirin_therapy_ L2 - http://www.diseaseinfosearch.org/result/3332 DB - PRIME DP - Unbound Medicine ER -