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[Natural history of Japanese patients with non-alcoholic fatty liver disease (NAFLD), especially non-alcoholic steatohepatitis (NASH) patients with hepatocellular carcinoma (HCC)].
Nihon Rinsho 2006; 64(6):1173-9NR

Abstract

Our current knowledge of the natural history of NAFLD can be summarized as follows: 1) simple steatosis can progress to steatohepatitis, fibrosis, cirrhosis, and even liver-related death but progression occurs in less than 5% of patients, 2) patients with NASH can progress to cirrhosis, 3) once cirrhosis develops in patients with NAFLD the prognosis appears to be poor with several studies reporting that some patients develop HCC and up to a third of patients develop liver-related morbidity or mortality, 4) older age and advanced fibrosis are risk factors for HCC in NASH. Changes in lifestyle have resulted in a dramatic increase in the prevalence of NAFLD. It is extremely important that we diagnose NASH definitely and perform appropriate treatment.

Authors+Show Affiliations

Department of Internal Medicine and Gastroenterology, Tokyo Women's Medical University.No affiliation info available

Pub Type(s)

English Abstract
Journal Article
Review

Language

jpn

PubMed ID

16768128

Citation

Yatsuji, Satoru, and Etsuko Hashimoto. "[Natural History of Japanese Patients With Non-alcoholic Fatty Liver Disease (NAFLD), Especially Non-alcoholic Steatohepatitis (NASH) Patients With Hepatocellular Carcinoma (HCC)]." Nihon Rinsho. Japanese Journal of Clinical Medicine, vol. 64, no. 6, 2006, pp. 1173-9.
Yatsuji S, Hashimoto E. [Natural history of Japanese patients with non-alcoholic fatty liver disease (NAFLD), especially non-alcoholic steatohepatitis (NASH) patients with hepatocellular carcinoma (HCC)]. Nippon Rinsho. 2006;64(6):1173-9.
Yatsuji, S., & Hashimoto, E. (2006). [Natural history of Japanese patients with non-alcoholic fatty liver disease (NAFLD), especially non-alcoholic steatohepatitis (NASH) patients with hepatocellular carcinoma (HCC)]. Nihon Rinsho. Japanese Journal of Clinical Medicine, 64(6), pp. 1173-9.
Yatsuji S, Hashimoto E. [Natural History of Japanese Patients With Non-alcoholic Fatty Liver Disease (NAFLD), Especially Non-alcoholic Steatohepatitis (NASH) Patients With Hepatocellular Carcinoma (HCC)]. Nippon Rinsho. 2006;64(6):1173-9. PubMed PMID: 16768128.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Natural history of Japanese patients with non-alcoholic fatty liver disease (NAFLD), especially non-alcoholic steatohepatitis (NASH) patients with hepatocellular carcinoma (HCC)]. AU - Yatsuji,Satoru, AU - Hashimoto,Etsuko, PY - 2006/6/14/pubmed PY - 2006/8/2/medline PY - 2006/6/14/entrez SP - 1173 EP - 9 JF - Nihon rinsho. Japanese journal of clinical medicine JO - Nippon Rinsho VL - 64 IS - 6 N2 - Our current knowledge of the natural history of NAFLD can be summarized as follows: 1) simple steatosis can progress to steatohepatitis, fibrosis, cirrhosis, and even liver-related death but progression occurs in less than 5% of patients, 2) patients with NASH can progress to cirrhosis, 3) once cirrhosis develops in patients with NAFLD the prognosis appears to be poor with several studies reporting that some patients develop HCC and up to a third of patients develop liver-related morbidity or mortality, 4) older age and advanced fibrosis are risk factors for HCC in NASH. Changes in lifestyle have resulted in a dramatic increase in the prevalence of NAFLD. It is extremely important that we diagnose NASH definitely and perform appropriate treatment. SN - 0047-1852 UR - https://www.unboundmedicine.com/medline/citation/16768128/[Natural_history_of_Japanese_patients_with_non_alcoholic_fatty_liver_disease__NAFLD__especially_non_alcoholic_steatohepatitis__NASH__patients_with_hepatocellular_carcinoma__HCC_]_ L2 - http://www.diseaseinfosearch.org/result/3338 DB - PRIME DP - Unbound Medicine ER -