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Study on drug release behaviors of poly-alpha,beta-[n-(2-hydroxyethyl)-L-aspartamide]-g-poly(epsilon-caprolactone) nano- and microparticles.
Biomacromolecules 2006; 7(6):2020-6B

Abstract

Biodegradable amphiphilic graft copolymers poly-alpha,beta-[N-(2-hydroxyethyl)-L-aspartamide]-g-poly(epsilon-caprolactone) (PHEA-g-PCL) with different branch lengths were synthesized through the ring-opening polymerization of epsilon-caprolactone initiated by the macroinitiator PHEA bearing hydroxyl groups. With use of the graft copolymers with different compositions, nanoparticle drug delivery systems with sizes smaller than 100 nm were prepared by a dialysis method, and microparticle drug delivery systems with sizes smaller than 5 microm were fabricated by a melting-emulsion method. The regularly spherical shapes of the drug-loaded nano- and microparticles were verified by transmission electron microscopy and scanning electron microscopy. In vitro drug release properties of nano- and microparticle drug delivery systems were investigated, with the emphasis on the effects of polymer composition, particle size, and drug-loading content on the release behaviors.

Authors+Show Affiliations

Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University, Wuhan 430072, PR China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16768428

Citation

Miao, Zhi-Mei, et al. "Study On Drug Release Behaviors of poly-alpha,beta-[n-(2-hydroxyethyl)-L-aspartamide]-g-poly(epsilon-caprolactone) Nano- and Microparticles." Biomacromolecules, vol. 7, no. 6, 2006, pp. 2020-6.
Miao ZM, Cheng SX, Zhang XZ, et al. Study on drug release behaviors of poly-alpha,beta-[n-(2-hydroxyethyl)-L-aspartamide]-g-poly(epsilon-caprolactone) nano- and microparticles. Biomacromolecules. 2006;7(6):2020-6.
Miao, Z. M., Cheng, S. X., Zhang, X. Z., & Zhuo, R. X. (2006). Study on drug release behaviors of poly-alpha,beta-[n-(2-hydroxyethyl)-L-aspartamide]-g-poly(epsilon-caprolactone) nano- and microparticles. Biomacromolecules, 7(6), pp. 2020-6.
Miao ZM, et al. Study On Drug Release Behaviors of poly-alpha,beta-[n-(2-hydroxyethyl)-L-aspartamide]-g-poly(epsilon-caprolactone) Nano- and Microparticles. Biomacromolecules. 2006;7(6):2020-6. PubMed PMID: 16768428.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Study on drug release behaviors of poly-alpha,beta-[n-(2-hydroxyethyl)-L-aspartamide]-g-poly(epsilon-caprolactone) nano- and microparticles. AU - Miao,Zhi-Mei, AU - Cheng,Si-Xue, AU - Zhang,Xian-Zheng, AU - Zhuo,Ren-Xi, PY - 2006/6/14/pubmed PY - 2006/11/10/medline PY - 2006/6/14/entrez SP - 2020 EP - 6 JF - Biomacromolecules JO - Biomacromolecules VL - 7 IS - 6 N2 - Biodegradable amphiphilic graft copolymers poly-alpha,beta-[N-(2-hydroxyethyl)-L-aspartamide]-g-poly(epsilon-caprolactone) (PHEA-g-PCL) with different branch lengths were synthesized through the ring-opening polymerization of epsilon-caprolactone initiated by the macroinitiator PHEA bearing hydroxyl groups. With use of the graft copolymers with different compositions, nanoparticle drug delivery systems with sizes smaller than 100 nm were prepared by a dialysis method, and microparticle drug delivery systems with sizes smaller than 5 microm were fabricated by a melting-emulsion method. The regularly spherical shapes of the drug-loaded nano- and microparticles were verified by transmission electron microscopy and scanning electron microscopy. In vitro drug release properties of nano- and microparticle drug delivery systems were investigated, with the emphasis on the effects of polymer composition, particle size, and drug-loading content on the release behaviors. SN - 1525-7797 UR - https://www.unboundmedicine.com/medline/citation/16768428/Study_on_drug_release_behaviors_of_poly_alphabeta_[n__2_hydroxyethyl__L_aspartamide]_g_poly_epsilon_caprolactone__nano__and_microparticles_ L2 - https://dx.doi.org/10.1021/bm060200o DB - PRIME DP - Unbound Medicine ER -