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Effect of zinc supplementation on in vitro copper-induced oxidation of low-density lipoproteins in healthy French subjects aged 55-70 years: the Zenith Study.
Br J Nutr 2006; 95(6):1134-42BJ

Abstract

Zn has been shown to possess antioxidant properties in vitro and in vivo. As inadequate dietary Zn intake has been reported in these populations, Zn supplementation may protect against oxidative stress and thereby limit the progression of degenerative diseases in such populations. We conducted the present study to evaluate the long-term supplementation effects of two moderate doses of Zn on in vitro Cu-induced LDL oxidation in French men and women. Three groups of sixteen healthy subjects aged 55-70 years from each sex participated in this randomized double-blind, placebo-controlled study. Each group received for six months either 0, 15 or 30 mg supplemental Zn per d. At the beginning and at the end of the supplementation periods, dietary intakes of Zn, Cu, Fe and vitamin E were estimated using 4 d food-intake records (including the weekend) and the GENI program. Zn, Cu, Fe and vitamin E status were also determined. In vitro LDL oxidizability (basal conjugated diene level, maximal conjugated diene formation and lag time) and lipid parameters were also determined. Dietary intakes of Zn, Cu, Fe and vitamin E were adequate in this population. Zn supplementation significantly increased serum Zn levels but did not significantly modify Cu, Fe or vitamin E status. However, Zn supplementation had no effect on in vitro LDL oxidation parameters, nor were there any sex-related differences in in vitro LDL oxidizability. The present study showed that long-term Zn supplementation of healthy subjects aged 55-70 years had no effect on in vitro Cu-induced LDL oxidation under the study conditions.

Authors+Show Affiliations

Centre de Recherche en Nutrition Humaine d'Auvergne, Unité Maladies Métaboliques et Micronutriments, INRA Clermont/Theix, France. cfeillet@ensam.inra.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16768836

Citation

Feillet-Coudray, Christine, et al. "Effect of Zinc Supplementation On in Vitro Copper-induced Oxidation of Low-density Lipoproteins in Healthy French Subjects Aged 55-70 Years: the Zenith Study." The British Journal of Nutrition, vol. 95, no. 6, 2006, pp. 1134-42.
Feillet-Coudray C, Meunier N, Bayle D, et al. Effect of zinc supplementation on in vitro copper-induced oxidation of low-density lipoproteins in healthy French subjects aged 55-70 years: the Zenith Study. Br J Nutr. 2006;95(6):1134-42.
Feillet-Coudray, C., Meunier, N., Bayle, D., Brandolini-Bunlon, M., Andriollo-Sanchez, M., O'Connor, J. M., ... Coudray, C. (2006). Effect of zinc supplementation on in vitro copper-induced oxidation of low-density lipoproteins in healthy French subjects aged 55-70 years: the Zenith Study. The British Journal of Nutrition, 95(6), pp. 1134-42.
Feillet-Coudray C, et al. Effect of Zinc Supplementation On in Vitro Copper-induced Oxidation of Low-density Lipoproteins in Healthy French Subjects Aged 55-70 Years: the Zenith Study. Br J Nutr. 2006;95(6):1134-42. PubMed PMID: 16768836.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of zinc supplementation on in vitro copper-induced oxidation of low-density lipoproteins in healthy French subjects aged 55-70 years: the Zenith Study. AU - Feillet-Coudray,Christine, AU - Meunier,Nathalie, AU - Bayle,Dominique, AU - Brandolini-Bunlon,Marion, AU - Andriollo-Sanchez,Maud, AU - O'Connor,Jacqueline M, AU - Maiani,Giuseppe, AU - Roussel,Anne-Marie, AU - Mazur,Andrzej, AU - Coudray,Charles, PY - 2006/6/14/pubmed PY - 2006/7/19/medline PY - 2006/6/14/entrez SP - 1134 EP - 42 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 95 IS - 6 N2 - Zn has been shown to possess antioxidant properties in vitro and in vivo. As inadequate dietary Zn intake has been reported in these populations, Zn supplementation may protect against oxidative stress and thereby limit the progression of degenerative diseases in such populations. We conducted the present study to evaluate the long-term supplementation effects of two moderate doses of Zn on in vitro Cu-induced LDL oxidation in French men and women. Three groups of sixteen healthy subjects aged 55-70 years from each sex participated in this randomized double-blind, placebo-controlled study. Each group received for six months either 0, 15 or 30 mg supplemental Zn per d. At the beginning and at the end of the supplementation periods, dietary intakes of Zn, Cu, Fe and vitamin E were estimated using 4 d food-intake records (including the weekend) and the GENI program. Zn, Cu, Fe and vitamin E status were also determined. In vitro LDL oxidizability (basal conjugated diene level, maximal conjugated diene formation and lag time) and lipid parameters were also determined. Dietary intakes of Zn, Cu, Fe and vitamin E were adequate in this population. Zn supplementation significantly increased serum Zn levels but did not significantly modify Cu, Fe or vitamin E status. However, Zn supplementation had no effect on in vitro LDL oxidation parameters, nor were there any sex-related differences in in vitro LDL oxidizability. The present study showed that long-term Zn supplementation of healthy subjects aged 55-70 years had no effect on in vitro Cu-induced LDL oxidation under the study conditions. SN - 0007-1145 UR - https://www.unboundmedicine.com/medline/citation/16768836/Effect_of_zinc_supplementation_on_in_vitro_copper_induced_oxidation_of_low_density_lipoproteins_in_healthy_French_subjects_aged_55_70_years:_the_Zenith_Study_ L2 - https://www.cambridge.org/core/product/identifier/S0007114506001528/type/journal_article DB - PRIME DP - Unbound Medicine ER -