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Dissociation between vascular oxidative stress and cardiovascular function in Wistar Kyoto and spontaneously hypertensive rats.
Vascul Pharmacol. 2006 Aug; 45(2):112-21.VP

Abstract

It has not been completely demonstrated if hypertension may, in part, develop as a result of increased oxidative stress (OS), inflammation and little is known about the short-term effects of antioxidant therapy. This study was designed to appreciate the effect of 7 days vitamin C-enriched diet (5 g/kg/day) on hemodynamic function and vascular OS in normotensive Wistar Kyoto rats and hypertensive rats (SHR). Aorta NAD(P)H oxidase activity was determinate and free radicals evaluated by electron spin resonance with a spin probe CP-H. Matrix metalloproteinase-1 (MMP-1) and monocyte chemoattractant protein-1 (MCP-1) expression were measured. The treatment with vitamin C did not change arterial pressure in SHR but prevented the increase in OS levels in SHR aortas. MMP-1 and MCP-1 expressions were more intense in the media of SHR aortas than in those of WKY rats but these expressions were not modified by vitamin C-pretreatment. Vitamin C-pretreatment was not able to protect heart against in vitro ischemia-reperfusion dysfunctions. These data may suggest that treatment with high doses of vitamin C in SHR can limit over-production of reactive oxygen species; however this effect was not accompanied with changes in arterial pressure and protection against I-R dysfunctions. Dissociation between vascular oxidative stress and cardiovascular function may be evoked.

Authors+Show Affiliations

Laboratoire de Physiopathologie et Pharmacologie Cardio-vasculaires Expérimentales, IFR no. 100, Facultés de Médecine et de Pharmacie, 7, Boulevard Jeanne d'Arc, 21000 Dijon, France. sicard123@yahoo.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16769252

Citation

Sicard, Pierre, et al. "Dissociation Between Vascular Oxidative Stress and Cardiovascular Function in Wistar Kyoto and Spontaneously Hypertensive Rats." Vascular Pharmacology, vol. 45, no. 2, 2006, pp. 112-21.
Sicard P, Oudot A, Guilland JC, et al. Dissociation between vascular oxidative stress and cardiovascular function in Wistar Kyoto and spontaneously hypertensive rats. Vascul Pharmacol. 2006;45(2):112-21.
Sicard, P., Oudot, A., Guilland, J. C., Moreau, D., Vergely, C., & Rochette, L. (2006). Dissociation between vascular oxidative stress and cardiovascular function in Wistar Kyoto and spontaneously hypertensive rats. Vascular Pharmacology, 45(2), 112-21.
Sicard P, et al. Dissociation Between Vascular Oxidative Stress and Cardiovascular Function in Wistar Kyoto and Spontaneously Hypertensive Rats. Vascul Pharmacol. 2006;45(2):112-21. PubMed PMID: 16769252.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dissociation between vascular oxidative stress and cardiovascular function in Wistar Kyoto and spontaneously hypertensive rats. AU - Sicard,Pierre, AU - Oudot,Alexandra, AU - Guilland,Jean-Claude, AU - Moreau,Daniel, AU - Vergely,Catherine, AU - Rochette,Luc, PY - 2006/01/09/received PY - 2006/04/19/revised PY - 2006/04/20/accepted PY - 2006/6/14/pubmed PY - 2007/2/10/medline PY - 2006/6/14/entrez SP - 112 EP - 21 JF - Vascular pharmacology JO - Vascul Pharmacol VL - 45 IS - 2 N2 - It has not been completely demonstrated if hypertension may, in part, develop as a result of increased oxidative stress (OS), inflammation and little is known about the short-term effects of antioxidant therapy. This study was designed to appreciate the effect of 7 days vitamin C-enriched diet (5 g/kg/day) on hemodynamic function and vascular OS in normotensive Wistar Kyoto rats and hypertensive rats (SHR). Aorta NAD(P)H oxidase activity was determinate and free radicals evaluated by electron spin resonance with a spin probe CP-H. Matrix metalloproteinase-1 (MMP-1) and monocyte chemoattractant protein-1 (MCP-1) expression were measured. The treatment with vitamin C did not change arterial pressure in SHR but prevented the increase in OS levels in SHR aortas. MMP-1 and MCP-1 expressions were more intense in the media of SHR aortas than in those of WKY rats but these expressions were not modified by vitamin C-pretreatment. Vitamin C-pretreatment was not able to protect heart against in vitro ischemia-reperfusion dysfunctions. These data may suggest that treatment with high doses of vitamin C in SHR can limit over-production of reactive oxygen species; however this effect was not accompanied with changes in arterial pressure and protection against I-R dysfunctions. Dissociation between vascular oxidative stress and cardiovascular function may be evoked. SN - 1537-1891 UR - https://www.unboundmedicine.com/medline/citation/16769252/Dissociation_between_vascular_oxidative_stress_and_cardiovascular_function_in_Wistar_Kyoto_and_spontaneously_hypertensive_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1537-1891(06)00101-7 DB - PRIME DP - Unbound Medicine ER -