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The effect of pentoxifylline in treatment of skin degloving injuries: an experimental study.
Injury. 2006 Jul; 37(7):638-41.I

Abstract

BACKGROUND

Management of skin degloving injuries is still a problematic issue and the avulsed part of the skin may become necrotic. In this pilot study, we attempted to develop an experimental model for degloving injuries and investigated the efficacy of pentoxifylline, a well-known potent agent in enhancement of erythrocyte flexibility and tissue vascularization, in treatment of this injury model.

METHODS

Degloving injuries were created in 15 rats' tails by circular puncturing of the skin at the middle of the tail and then applying moderate force to avulse the skin from the underlying tissue. Then, the skin was repaired back to its original position. No treatment was given in the first group (n=6). In the second group (n=3), 0.4cm(3) physiological serum was administered intraperitoneally for 10 days. In the third group (n=6), intraperitoneal 25mg/kg pentoxifylline was administered for 10 days. Tails were observed daily for 21 days and then examined histopathologically.

RESULTS

At the end of the study, the avulsed segment of the skin became cyanotic and ulcerated in the first and the second group, and in the third group, the skin was intact. In histopathological examination, loss of superficial ephitelium and dense infiltration of inflammatory cells were seen in groups 1 and 2, and the skin layers were normal in the group 3.

CONCLUSION

Pentoxifylline improved tissue preservation and was proved to be highly beneficial in treatment of skin degloving injuries.

Authors+Show Affiliations

Department of Orthopaedics, Mersin University School of Medicine, Ihsaniye Mah, 4935 Sokak No. 3, 33079 Mersin, Turkey. oztuna67@mersin.edu.trNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16769312

Citation

Oztuna, Volkan, et al. "The Effect of Pentoxifylline in Treatment of Skin Degloving Injuries: an Experimental Study." Injury, vol. 37, no. 7, 2006, pp. 638-41.
Oztuna V, Eskandari MM, Unal S, et al. The effect of pentoxifylline in treatment of skin degloving injuries: an experimental study. Injury. 2006;37(7):638-41.
Oztuna, V., Eskandari, M. M., Unal, S., Colak, M., & Karabacak, T. (2006). The effect of pentoxifylline in treatment of skin degloving injuries: an experimental study. Injury, 37(7), 638-41.
Oztuna V, et al. The Effect of Pentoxifylline in Treatment of Skin Degloving Injuries: an Experimental Study. Injury. 2006;37(7):638-41. PubMed PMID: 16769312.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of pentoxifylline in treatment of skin degloving injuries: an experimental study. AU - Oztuna,Volkan, AU - Eskandari,Metin M, AU - Unal,Sakir, AU - Colak,Mehmet, AU - Karabacak,Tuba, PY - 2005/11/28/received PY - 2006/02/06/revised PY - 2006/02/20/accepted PY - 2006/6/14/pubmed PY - 2007/5/2/medline PY - 2006/6/14/entrez SP - 638 EP - 41 JF - Injury JO - Injury VL - 37 IS - 7 N2 - BACKGROUND: Management of skin degloving injuries is still a problematic issue and the avulsed part of the skin may become necrotic. In this pilot study, we attempted to develop an experimental model for degloving injuries and investigated the efficacy of pentoxifylline, a well-known potent agent in enhancement of erythrocyte flexibility and tissue vascularization, in treatment of this injury model. METHODS: Degloving injuries were created in 15 rats' tails by circular puncturing of the skin at the middle of the tail and then applying moderate force to avulse the skin from the underlying tissue. Then, the skin was repaired back to its original position. No treatment was given in the first group (n=6). In the second group (n=3), 0.4cm(3) physiological serum was administered intraperitoneally for 10 days. In the third group (n=6), intraperitoneal 25mg/kg pentoxifylline was administered for 10 days. Tails were observed daily for 21 days and then examined histopathologically. RESULTS: At the end of the study, the avulsed segment of the skin became cyanotic and ulcerated in the first and the second group, and in the third group, the skin was intact. In histopathological examination, loss of superficial ephitelium and dense infiltration of inflammatory cells were seen in groups 1 and 2, and the skin layers were normal in the group 3. CONCLUSION: Pentoxifylline improved tissue preservation and was proved to be highly beneficial in treatment of skin degloving injuries. SN - 0020-1383 UR - https://www.unboundmedicine.com/medline/citation/16769312/The_effect_of_pentoxifylline_in_treatment_of_skin_degloving_injuries:_an_experimental_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0020-1383(06)00087-8 DB - PRIME DP - Unbound Medicine ER -