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Infrared spectrophotometry of intraluminal meconium calculi in a neonate with imperforate anus and rectourethral fistula.
J Pediatr Surg. 2006 Jun; 41(6):1173-6.JP

Abstract

BACKGROUND/PURPOSE

Intraluminal meconium calculi are a rare cause of neonatal abdominal calcifications in patients with anorectal malformations. To investigate their pathogenesis, we performed infrared spectroscopic analysis of meconium-calcified lesions.

METHODS

Meconium calculi were collected from the colostomy in a newborn patient with imperforate anus and rectourethral fistula. The potassium bromide method was employed to obtain the infrared absorption spectrum of the meconium calculi.

RESULTS

The wavelength pattern of the meconium calculi exhibited 4 specific peaks at 1570, 1390, 1105, and 1005 cm(-1) between 22% and 45% transmittance values. The unique absorption spectrum exclusively indicated ammonium hydrogen urate (C(5)N(5)O(3)H(7)), having the combined constituents of ammonium and uric acid.

CONCLUSIONS

These results suggest that the intraluminal meconium calculi were originally derived from meconium and fetal urine. The stasis of meconium passage and fetal urine mixing through the rectourethral fistula in a low-pH condition was deduced to be the main cause of this rare stone formation.

Authors+Show Affiliations

Shimotake T
Division of Surgery, Children's Research Hospital, Kyoto Prefectural University of Medicine, Kyoto 602-0841, Japan. shimotake@ujitoku.or.jp
Higuchi K
No affiliation info available
Tsuda T
No affiliation info available
Aoi S
No affiliation info available
Iwai N
No affiliation info available

MeSH

Anus, ImperforateCalculiColonColonic DiseasesHumansInfant, NewbornMaleMeconiumRadiographyRectal FistulaSpectrophotometry, InfraredUrethral DiseasesUrinary Fistula

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16769356

Citation

Shimotake, Takashi, et al. "Infrared Spectrophotometry of Intraluminal Meconium Calculi in a Neonate With Imperforate Anus and Rectourethral Fistula." Journal of Pediatric Surgery, vol. 41, no. 6, 2006, pp. 1173-6.
Shimotake T, Higuchi K, Tsuda T, et al. Infrared spectrophotometry of intraluminal meconium calculi in a neonate with imperforate anus and rectourethral fistula. J Pediatr Surg. 2006;41(6):1173-6.
Shimotake, T., Higuchi, K., Tsuda, T., Aoi, S., & Iwai, N. (2006). Infrared spectrophotometry of intraluminal meconium calculi in a neonate with imperforate anus and rectourethral fistula. Journal of Pediatric Surgery, 41(6), 1173-6.
Shimotake T, et al. Infrared Spectrophotometry of Intraluminal Meconium Calculi in a Neonate With Imperforate Anus and Rectourethral Fistula. J Pediatr Surg. 2006;41(6):1173-6. PubMed PMID: 16769356.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Infrared spectrophotometry of intraluminal meconium calculi in a neonate with imperforate anus and rectourethral fistula. AU - Shimotake,Takashi, AU - Higuchi,Kohji, AU - Tsuda,Tomoki, AU - Aoi,Shigeyoshi, AU - Iwai,Naomi, PY - 2006/6/14/pubmed PY - 2006/10/3/medline PY - 2006/6/14/entrez SP - 1173 EP - 6 JF - Journal of pediatric surgery JO - J Pediatr Surg VL - 41 IS - 6 N2 - BACKGROUND/PURPOSE: Intraluminal meconium calculi are a rare cause of neonatal abdominal calcifications in patients with anorectal malformations. To investigate their pathogenesis, we performed infrared spectroscopic analysis of meconium-calcified lesions. METHODS: Meconium calculi were collected from the colostomy in a newborn patient with imperforate anus and rectourethral fistula. The potassium bromide method was employed to obtain the infrared absorption spectrum of the meconium calculi. RESULTS: The wavelength pattern of the meconium calculi exhibited 4 specific peaks at 1570, 1390, 1105, and 1005 cm(-1) between 22% and 45% transmittance values. The unique absorption spectrum exclusively indicated ammonium hydrogen urate (C(5)N(5)O(3)H(7)), having the combined constituents of ammonium and uric acid. CONCLUSIONS: These results suggest that the intraluminal meconium calculi were originally derived from meconium and fetal urine. The stasis of meconium passage and fetal urine mixing through the rectourethral fistula in a low-pH condition was deduced to be the main cause of this rare stone formation. SN - 1531-5037 UR - https://www.unboundmedicine.com/medline/citation/16769356/Infrared_spectrophotometry_of_intraluminal_meconium_calculi_in_a_neonate_with_imperforate_anus_and_rectourethral_fistula_ DB - PRIME DP - Unbound Medicine ER -