Tags

Type your tag names separated by a space and hit enter

Long-term efficacy of mupirocin in the prevention of infections with meticillin-resistant Staphylococcus aureus in a gastroenterology unit.
J Hosp Infect. 2006 Aug; 63(4):385-92.JH

Abstract

The long-term efficacy (55 months) of eradication of nasal carriage of meticillin-resistant Staphylococcus aureus (MRSA) by mupirocin was assessed for MRSA infections in a gastroenterology unit receiving patients for long hospital stays. In total, 2242 patients were included in the study; 92% had been hospitalized in another hospital before admission to the study department, 64% had chronic liver diseases (LD), 25% had miscellaneous medical conditions and 11% were admitted following gastroenterological surgery. Three consecutive periods were considered in the analysis. Nasal carriage at admission was similar in all three periods (10.9 vs 7.5 vs 8.6% in Periods 1, 2 and 3, respectively), while acquired nasal carriage decreased in the whole population (14.3 vs 16.2 vs 10.2% in Periods 1, 2 and 3, respectively, P=0.006) and in LD patients (15.8 vs 18.7 vs 11.9% in Periods 1, 2 and 3, respectively, P=0.018). The incidence of MRSA infections (N per total number of hospitalization-days) was 1.41 per 1000 in the year before initiation of eradication, 1.40 in Period 1, 0.74 in Period 2 and 0.59 in Period 3 (P=0.022). The incidence of MRSA infections among patients was 7.0% in Period 1, 3.7% in Period 2 and 3.1% in Period 3 in LD patients (P=0.0062). The corresponding figures were 5.5, 3.0 and 2.4% for the whole population (P=0.0024). The mortality caused by MRSA was 0.31, 0.19 and 0.13% (P=0.035) in Periods 1, 2 and 3, respectively. The numbers of resistant strains among those acquired during hospitalization were 12 in Period 1, four in Period 2 and six in Period 3. Long-term intranasal mupirocin treatment in MRSA carrier patients with long hospital stay is associated with a decrease in acquired carriage and MRSA infections, while resistance of the strains to mupirocin does not increase provided that colonized patients are only treated once.

Authors+Show Affiliations

Service de Bactériologie-Virologie-Hygiène, Hôpital Henri Mondor, Assistance Publique-Hopitaux de Paris, Créteil, France. catherine.dupeyron@hmn.ap-hop-paris.frNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16772100

Citation

Dupeyron, C, et al. "Long-term Efficacy of Mupirocin in the Prevention of Infections With Meticillin-resistant Staphylococcus Aureus in a Gastroenterology Unit." The Journal of Hospital Infection, vol. 63, no. 4, 2006, pp. 385-92.
Dupeyron C, Campillo B, Richardet JP, et al. Long-term efficacy of mupirocin in the prevention of infections with meticillin-resistant Staphylococcus aureus in a gastroenterology unit. J Hosp Infect. 2006;63(4):385-92.
Dupeyron, C., Campillo, B., Richardet, J. P., & Soussy, C. J. (2006). Long-term efficacy of mupirocin in the prevention of infections with meticillin-resistant Staphylococcus aureus in a gastroenterology unit. The Journal of Hospital Infection, 63(4), 385-92.
Dupeyron C, et al. Long-term Efficacy of Mupirocin in the Prevention of Infections With Meticillin-resistant Staphylococcus Aureus in a Gastroenterology Unit. J Hosp Infect. 2006;63(4):385-92. PubMed PMID: 16772100.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-term efficacy of mupirocin in the prevention of infections with meticillin-resistant Staphylococcus aureus in a gastroenterology unit. AU - Dupeyron,C, AU - Campillo,B, AU - Richardet,J-P, AU - Soussy,C-J, Y1 - 2006/06/12/ PY - 2005/05/24/received PY - 2006/03/27/accepted PY - 2006/6/15/pubmed PY - 2006/10/5/medline PY - 2006/6/15/entrez SP - 385 EP - 92 JF - The Journal of hospital infection JO - J. Hosp. Infect. VL - 63 IS - 4 N2 - The long-term efficacy (55 months) of eradication of nasal carriage of meticillin-resistant Staphylococcus aureus (MRSA) by mupirocin was assessed for MRSA infections in a gastroenterology unit receiving patients for long hospital stays. In total, 2242 patients were included in the study; 92% had been hospitalized in another hospital before admission to the study department, 64% had chronic liver diseases (LD), 25% had miscellaneous medical conditions and 11% were admitted following gastroenterological surgery. Three consecutive periods were considered in the analysis. Nasal carriage at admission was similar in all three periods (10.9 vs 7.5 vs 8.6% in Periods 1, 2 and 3, respectively), while acquired nasal carriage decreased in the whole population (14.3 vs 16.2 vs 10.2% in Periods 1, 2 and 3, respectively, P=0.006) and in LD patients (15.8 vs 18.7 vs 11.9% in Periods 1, 2 and 3, respectively, P=0.018). The incidence of MRSA infections (N per total number of hospitalization-days) was 1.41 per 1000 in the year before initiation of eradication, 1.40 in Period 1, 0.74 in Period 2 and 0.59 in Period 3 (P=0.022). The incidence of MRSA infections among patients was 7.0% in Period 1, 3.7% in Period 2 and 3.1% in Period 3 in LD patients (P=0.0062). The corresponding figures were 5.5, 3.0 and 2.4% for the whole population (P=0.0024). The mortality caused by MRSA was 0.31, 0.19 and 0.13% (P=0.035) in Periods 1, 2 and 3, respectively. The numbers of resistant strains among those acquired during hospitalization were 12 in Period 1, four in Period 2 and six in Period 3. Long-term intranasal mupirocin treatment in MRSA carrier patients with long hospital stay is associated with a decrease in acquired carriage and MRSA infections, while resistance of the strains to mupirocin does not increase provided that colonized patients are only treated once. SN - 0195-6701 UR - https://www.unboundmedicine.com/medline/citation/16772100/Long_term_efficacy_of_mupirocin_in_the_prevention_of_infections_with_meticillin_resistant_Staphylococcus_aureus_in_a_gastroenterology_unit_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0195-6701(06)00212-X DB - PRIME DP - Unbound Medicine ER -