Tags

Type your tag names separated by a space and hit enter

Prevention of diabetes and cardiovascular disease in women with PCOS: treatment with insulin sensitizers.
Best Pract Res Clin Endocrinol Metab. 2006 Jun; 20(2):245-60.BP

Abstract

Polycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility in United States, affecting 6-10% of females in the reproductive age group. Recent studies have shown that insulin resistance plays an important role in the pathogenesis of PCOS. Traditionally, management of PCOS consisted mainly of ovulation induction, treatment of acne and hirsutism, and prevention of endometrial cancer. However, with mounting evidence showing that PCOS is associated with dysmetabolic syndrome and an increased risk for developing diabetes and heart disease, this can no longer be our sole focus. Current data support a strong recommendation that women with PCOS should undergo comprehensive evaluation for diabetes and recognized cardiovascular risk factors and receive appropriate treatment as needed. Lifestyle modifications remain the first-line therapy for all obese women with PCOS. However, many obese women with PCOS find weight loss difficult to achieve and maintain, and this is not an option for lean women with PCOS. For these reasons, insulin-sensitizing drugs are proving to be a promising and unique therapeutic option for chronic treatment of PCOS.

Authors+Show Affiliations

Division of Endocrinology and Metabolism, Medical College of Virginia, Virginia Commonwealth University, P.O. Box 980111, Richmond, VA 23298-0111, USA. susmeetasharma@yahoo.comNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16772155

Citation

Sharma, Susmeeta T., and John E. Nestler. "Prevention of Diabetes and Cardiovascular Disease in Women With PCOS: Treatment With Insulin Sensitizers." Best Practice & Research. Clinical Endocrinology & Metabolism, vol. 20, no. 2, 2006, pp. 245-60.
Sharma ST, Nestler JE. Prevention of diabetes and cardiovascular disease in women with PCOS: treatment with insulin sensitizers. Best Pract Res Clin Endocrinol Metab. 2006;20(2):245-60.
Sharma, S. T., & Nestler, J. E. (2006). Prevention of diabetes and cardiovascular disease in women with PCOS: treatment with insulin sensitizers. Best Practice & Research. Clinical Endocrinology & Metabolism, 20(2), 245-60.
Sharma ST, Nestler JE. Prevention of Diabetes and Cardiovascular Disease in Women With PCOS: Treatment With Insulin Sensitizers. Best Pract Res Clin Endocrinol Metab. 2006;20(2):245-60. PubMed PMID: 16772155.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevention of diabetes and cardiovascular disease in women with PCOS: treatment with insulin sensitizers. AU - Sharma,Susmeeta T, AU - Nestler,John E, PY - 2006/6/15/pubmed PY - 2006/8/12/medline PY - 2006/6/15/entrez SP - 245 EP - 60 JF - Best practice & research. Clinical endocrinology & metabolism JO - Best Pract Res Clin Endocrinol Metab VL - 20 IS - 2 N2 - Polycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility in United States, affecting 6-10% of females in the reproductive age group. Recent studies have shown that insulin resistance plays an important role in the pathogenesis of PCOS. Traditionally, management of PCOS consisted mainly of ovulation induction, treatment of acne and hirsutism, and prevention of endometrial cancer. However, with mounting evidence showing that PCOS is associated with dysmetabolic syndrome and an increased risk for developing diabetes and heart disease, this can no longer be our sole focus. Current data support a strong recommendation that women with PCOS should undergo comprehensive evaluation for diabetes and recognized cardiovascular risk factors and receive appropriate treatment as needed. Lifestyle modifications remain the first-line therapy for all obese women with PCOS. However, many obese women with PCOS find weight loss difficult to achieve and maintain, and this is not an option for lean women with PCOS. For these reasons, insulin-sensitizing drugs are proving to be a promising and unique therapeutic option for chronic treatment of PCOS. SN - 1521-690X UR - https://www.unboundmedicine.com/medline/citation/16772155/Prevention_of_diabetes_and_cardiovascular_disease_in_women_with_PCOS:_treatment_with_insulin_sensitizers_ DB - PRIME DP - Unbound Medicine ER -