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Role of lifestyle modification in the management of polycystic ovary syndrome.
Best Pract Res Clin Endocrinol Metab. 2006 Jun; 20(2):293-310.BP

Abstract

Overweight and obesity are common findings in polycystic ovary syndrome (PCOS). Obesity-particularly central obesity-is strongly indicated as a cause of insulin resistance, a central feature of PCOS. The prevalence of obesity is reaching epidemic proportions in many developed countries, and this increase is of particular concern in adolescent women. Obesity worsens both the metabolic and endocrine profiles in PCOS and may decrease the response to treatment. In the short term, weight reduction improves both metabolic and endocrine aspects of PCOS as well as clinical markers such as ovulation. However, extreme non-surgical efforts to lose weight are rarely successful and are associated with high rates of weight regain. Lifestyle modification with modest weight loss goals of 5-10% appear to be equally effective in restoring fertility and may be more compatible with long-term success; however, further research is needed.

Authors+Show Affiliations

Hoeger KM
Department of Obstetrics and Gynecology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 668, Rochester, NY 14642, USA. kathy_hoeger@urmc.rochester.edu

MeSH

AdolescentDiabetes Mellitus, Type 2FemaleGlucose Tolerance TestHumansInfertility, FemaleInsulin ResistanceIntra-Abdominal FatMetabolic SyndromeObesityPolycystic Ovary SyndromeRisk Reduction BehaviorWeight Loss

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

16772159

Citation

Hoeger, Kathleen M.. "Role of Lifestyle Modification in the Management of Polycystic Ovary Syndrome." Best Practice & Research. Clinical Endocrinology & Metabolism, vol. 20, no. 2, 2006, pp. 293-310.
Hoeger KM. Role of lifestyle modification in the management of polycystic ovary syndrome. Best Pract Res Clin Endocrinol Metab. 2006;20(2):293-310.
Hoeger, K. M. (2006). Role of lifestyle modification in the management of polycystic ovary syndrome. Best Practice & Research. Clinical Endocrinology & Metabolism, 20(2), 293-310.
Hoeger KM. Role of Lifestyle Modification in the Management of Polycystic Ovary Syndrome. Best Pract Res Clin Endocrinol Metab. 2006;20(2):293-310. PubMed PMID: 16772159.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of lifestyle modification in the management of polycystic ovary syndrome. A1 - Hoeger,Kathleen M, PY - 2006/6/15/pubmed PY - 2006/8/12/medline PY - 2006/6/15/entrez SP - 293 EP - 310 JF - Best practice & research. Clinical endocrinology & metabolism JO - Best Pract Res Clin Endocrinol Metab VL - 20 IS - 2 N2 - Overweight and obesity are common findings in polycystic ovary syndrome (PCOS). Obesity-particularly central obesity-is strongly indicated as a cause of insulin resistance, a central feature of PCOS. The prevalence of obesity is reaching epidemic proportions in many developed countries, and this increase is of particular concern in adolescent women. Obesity worsens both the metabolic and endocrine profiles in PCOS and may decrease the response to treatment. In the short term, weight reduction improves both metabolic and endocrine aspects of PCOS as well as clinical markers such as ovulation. However, extreme non-surgical efforts to lose weight are rarely successful and are associated with high rates of weight regain. Lifestyle modification with modest weight loss goals of 5-10% appear to be equally effective in restoring fertility and may be more compatible with long-term success; however, further research is needed. SN - 1521-690X UR - https://www.unboundmedicine.com/medline/citation/16772159/Role_of_lifestyle_modification_in_the_management_of_polycystic_ovary_syndrome_ DB - PRIME DP - Unbound Medicine ER -